Reward circuitry responsivity to food predicts future increases in body mass: moderating effects of DRD2 and DRD4.
Reads0
Chats0
TLDR
This novel prospective fMRI study indicates that responsivity of reward circuitry to food increases risk for future weight gain, but that genes that impact dopamine signaling capacity moderate the predictive effects, suggesting two qualitatively distinct pathways to unhealthy weight gain based on genetic risk.About:
This article is published in NeuroImage.The article was published on 2010-05-01 and is currently open access. It has received 311 citations till now.read more
Citations
More filters
Impulsivity (fg moeller and d ramesh, section editors)
TL;DR: A review of the relationship between food cue reactivity and impulsivity in obesity epidemic can be found in this article, where the authors discuss the relationship of food cue reaction to food-associated cues and impulsive response to food cues.
Book ChapterDOI
Obesity and appetite: Evidence for a neurobehavioral model of obesity risk and maintenance
Роль генетического полиморфизма TaqIA гена дофаминового рецептора 2 типа, уровня дофамина и лептина крови в формировании разных форм ожирения у детей
TL;DR: In this article, the role of TaqIA genetic polymorphism of D2 dopamine receptor gene, neuropeptides (leptin, dopamine) level in blood in development of excess body weight in children with various forms of obesity.
70th Anniversary Conference on 'Body weight regulation - food, gut and brain signalling' Symposium III: Brain signalling and onwards communications Food-induced brain responses and eating behaviour
TL;DR: The current state of the field of ‘nutritional neuroscience’ is reviewed with a focus on the interplay between food-induced brain responses and eating behaviour and research needs and techniques that could be used to address these are highlighted.
References
More filters
Book
Applied Linear Statistical Models
TL;DR: Applied Linear Statistical Models 5e as discussed by the authors is the leading authoritative text and reference on statistical modeling, which includes brief introductory and review material, and then proceeds through regression and modeling for the first half, and through ANOVA and Experimental Design in the second half.
Journal ArticleDOI
Applied Linear Statistical Models
Journal ArticleDOI
Analysis of fMRI time-series revisited--again.
Keith J. Worsley,Karl J. Friston +1 more
TL;DR: Correct results are presented that replace those of the previous paper and solve the same problem without recourse to heuristic arguments and a proper and unbiased estimator for the error terms are introduced.
Journal ArticleDOI
Brain dopamine and obesity.
Gene-Jack Wang,Gene-Jack Wang,Nora D. Volkow,Nora D. Volkow,Jean Logan,Naoml R Pappas,Christopher Wong,Wel Zhu,Noelwah Netusll,Joanna S. Fowler +9 more
TL;DR: Dopamine modulates motivation and reward circuits and hence dopamine deficiency in obese individuals may perpetuate pathological eating as a means to compensate for decreased activation of these circuits.
Journal ArticleDOI
Allelic discrimination using fluorogenic probes and the 5' nuclease assay.
TL;DR: The 5' nuclease (TaqMan) as discussed by the authors is a typical PCR that uses a fluorogenic probe, consisting of an oligonucleotide labeled with both a fluorescent reporter dye and a quencher dye.