Reward circuitry responsivity to food predicts future increases in body mass: moderating effects of DRD2 and DRD4.
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TLDR
This novel prospective fMRI study indicates that responsivity of reward circuitry to food increases risk for future weight gain, but that genes that impact dopamine signaling capacity moderate the predictive effects, suggesting two qualitatively distinct pathways to unhealthy weight gain based on genetic risk.About:
This article is published in NeuroImage.The article was published on 2010-05-01 and is currently open access. It has received 311 citations till now.read more
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Journal ArticleDOI
An Explorative Analysis of Binge Eating Disorder Impulsivity among Obese Candidates to Bariatric Surgery
TL;DR: This study shows that BED obese subjects suffer from a global impulsivity disorder, and the alterations of its inner factors associated to EDI-2 subscales determines poor compliance after bariatric surgery and weight regain.
Book ChapterDOI
Brain, Environment, Hormone-Based Appetite, Ingestive Behavior, and Body Weight
TL;DR: This chapter will focus on how different internal and external factors influence central control of appetite, energy intake, and weight status, as well as how eating patterns may alter the brain’s response to food stimuli.
Journal ArticleDOI
Associations among body mass index, working memory performance, gray matter volume, and brain activation in healthy children.
Yaqin Zhang,Weibin Ji,Fukun Jiang,Feifei Wu,Guanya Li,Yang Hu,Wenchao Zhang,Jia Wang,Xiao Fan,Xiaorong Wei,Peter Manza,Dardo Tomasi,Nora D. Volkow,Xinbo Gao,Gene-Jack Wang,Yi Zhang +15 more
TL;DR: In this paper , the authors investigated the neural mechanisms underlying the association between poorer working memory performance and higher body mass index (BMI) in children and found that higher BMI is associated with smaller gray matter volumes and weaker brain activation in regions involved with working memory.
Journal ArticleDOI
Commentary: Differential associations between obesity and behavioral measures of impulsivity.
TL;DR: The results demonstrate that the former two constructs are related to body mass index and obesity, while the latter is not, and it is plausible that the strength of the relationships between weight status and discounting appear greater than that between weight and inhibition due to the motivational nature of the discounting tasks.
Dissertation
Neurostructural Correlates of Body Mass Index and Waist Circumference in Adolescents with Bipolar Disorder
TL;DR: In this article, the authors examined the effect of obesity on brain structure in youth with bipolar disorder on cortical region of interest (ROI) volumes and cortical thickness for frontal lobe (FL), prefrontal cortex (PFC), and orbitofrontal cortex (OFC).
References
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Book
Applied Linear Statistical Models
TL;DR: Applied Linear Statistical Models 5e as discussed by the authors is the leading authoritative text and reference on statistical modeling, which includes brief introductory and review material, and then proceeds through regression and modeling for the first half, and through ANOVA and Experimental Design in the second half.
Journal ArticleDOI
Applied Linear Statistical Models
Journal ArticleDOI
Analysis of fMRI time-series revisited--again.
Keith J. Worsley,Karl J. Friston +1 more
TL;DR: Correct results are presented that replace those of the previous paper and solve the same problem without recourse to heuristic arguments and a proper and unbiased estimator for the error terms are introduced.
Journal ArticleDOI
Brain dopamine and obesity.
Gene-Jack Wang,Gene-Jack Wang,Nora D. Volkow,Nora D. Volkow,Jean Logan,Naoml R Pappas,Christopher Wong,Wel Zhu,Noelwah Netusll,Joanna S. Fowler +9 more
TL;DR: Dopamine modulates motivation and reward circuits and hence dopamine deficiency in obese individuals may perpetuate pathological eating as a means to compensate for decreased activation of these circuits.
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Allelic discrimination using fluorogenic probes and the 5' nuclease assay.
TL;DR: The 5' nuclease (TaqMan) as discussed by the authors is a typical PCR that uses a fluorogenic probe, consisting of an oligonucleotide labeled with both a fluorescent reporter dye and a quencher dye.