Reward circuitry responsivity to food predicts future increases in body mass: moderating effects of DRD2 and DRD4.
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TLDR
This novel prospective fMRI study indicates that responsivity of reward circuitry to food increases risk for future weight gain, but that genes that impact dopamine signaling capacity moderate the predictive effects, suggesting two qualitatively distinct pathways to unhealthy weight gain based on genetic risk.About:
This article is published in NeuroImage.The article was published on 2010-05-01 and is currently open access. It has received 311 citations till now.read more
Citations
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Basic and Genetic Aspects of Food Intake Control and Obesity: Role of Dopamin Receptor D2 TaqIA Polymorphism
TL;DR: The role of the dopamine receptor D2 gene TaqAI polymorphism, which affects the D2 receptor availability and has been associated to obesity is highlighted.
Journal ArticleDOI
Heart Rate Variability Reactivity to Food Image Stimuli is Associated with Body Mass Index.
Jung Chi Chang,Wei-Lieh Huang,Chao Yu Liu,Chao Yu Liu,Meg Mei Chih Tseng,Meg Mei Chih Tseng,Cheryl C.H. Yang,Terry B.J. Kuo +7 more
TL;DR: In this paper, the influence of body mass index (BMI), disordered eating behaviors, and sex on the heart rate variability (HRV) reactivity to food in a nonclinical sample was examined.
Food intake meeting energy and reward homeostasis
TL;DR: The final author version and the galley proof are versions of the publication after peer review that features the final layout of the paper including the volume, issue and page numbers.
Dissertation
The Hunger Hormone Ghrelin Dynamically Tunes Phasic Mesolimbic Signals Underlying Food-Directed Behaviors
TL;DR: It is demonstrated that intra-VTA orexin could be a plausible mechanism underlying the ability of central and LH ghrelin to regulate food-evoked dopamine release and both phasic releases and increases in NAc activity evoked by a food-predictive cue.
Dissertation
Repenser la désinhibition alimentaire dans l’obésité, sous l’angle de l’hypothèse de l’addiction à l’alimentation
TL;DR: In this article, a revue de la litterature a permis de montrer l'existence d'interaction etroite entre les niveaux de regulation du comportement alimentaire and comment AA pourrait en etre un exemple de deregulation.
References
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Book
Applied Linear Statistical Models
TL;DR: Applied Linear Statistical Models 5e as discussed by the authors is the leading authoritative text and reference on statistical modeling, which includes brief introductory and review material, and then proceeds through regression and modeling for the first half, and through ANOVA and Experimental Design in the second half.
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Applied Linear Statistical Models
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Analysis of fMRI time-series revisited--again.
Keith J. Worsley,Karl J. Friston +1 more
TL;DR: Correct results are presented that replace those of the previous paper and solve the same problem without recourse to heuristic arguments and a proper and unbiased estimator for the error terms are introduced.
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Brain dopamine and obesity.
Gene-Jack Wang,Gene-Jack Wang,Nora D. Volkow,Nora D. Volkow,Jean Logan,Naoml R Pappas,Christopher Wong,Wel Zhu,Noelwah Netusll,Joanna S. Fowler +9 more
TL;DR: Dopamine modulates motivation and reward circuits and hence dopamine deficiency in obese individuals may perpetuate pathological eating as a means to compensate for decreased activation of these circuits.
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Allelic discrimination using fluorogenic probes and the 5' nuclease assay.
TL;DR: The 5' nuclease (TaqMan) as discussed by the authors is a typical PCR that uses a fluorogenic probe, consisting of an oligonucleotide labeled with both a fluorescent reporter dye and a quencher dye.