Reward circuitry responsivity to food predicts future increases in body mass: moderating effects of DRD2 and DRD4.
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TLDR
This novel prospective fMRI study indicates that responsivity of reward circuitry to food increases risk for future weight gain, but that genes that impact dopamine signaling capacity moderate the predictive effects, suggesting two qualitatively distinct pathways to unhealthy weight gain based on genetic risk.About:
This article is published in NeuroImage.The article was published on 2010-05-01 and is currently open access. It has received 311 citations till now.read more
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Moving the Brain: Neuroimaging Motivational Changes of Deep Brain Stimulation in Obsessive-Compulsive Disorder
TL;DR: This thesis will answer this intriguing question by studying brain networks related to reward and motivation in OCD patients, and how effective DBS influences these networks.
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Commentary: Gain in Body Fat Is Associated with Increased Striatal Response to Palatable Food Cues, whereas Body Fat Stability Is Associated with Decreased Striatal Response.
TL;DR: Commentary: Gain in Body Fat Is Associated with Increased Striatal Response to Palatable Food Cues, whereas Body Fat Stability is Associated with Decreasedstriatal Response.
Posted ContentDOI
Reward-related regions form a preferentially coupled system at rest
Jeremy F. Huckins,Babatunde Adeyemo,F.M. Miezin,Jonathan D. Power,Evan M. Gordon,Timothy O. Laumann,Todd F. Heatherton,Steven E. Petersen,William M. Kelley +8 more
TL;DR: It is proposed that future work may be able to interrogate group or individual differences in connectivity profiles using the regions delineated in the current work to explore potential relationships to appetitive behaviors, self-regulation failure, and addiction.
Dissertation
Exploring the Role of BDNF and NTRK2 Genetic Polymorphisms on Eating Behaviours in Young Children
TL;DR: The role of BDNF and NTRK2 SNPs on eating behaviours in young children and an association between N TRK2 rs1078947 and Food Approach Score from the CEBQ that was trending towards significance are investigated.
References
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Book
Applied Linear Statistical Models
TL;DR: Applied Linear Statistical Models 5e as discussed by the authors is the leading authoritative text and reference on statistical modeling, which includes brief introductory and review material, and then proceeds through regression and modeling for the first half, and through ANOVA and Experimental Design in the second half.
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Applied Linear Statistical Models
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Analysis of fMRI time-series revisited--again.
Keith J. Worsley,Karl J. Friston +1 more
TL;DR: Correct results are presented that replace those of the previous paper and solve the same problem without recourse to heuristic arguments and a proper and unbiased estimator for the error terms are introduced.
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Brain dopamine and obesity.
Gene-Jack Wang,Gene-Jack Wang,Nora D. Volkow,Nora D. Volkow,Jean Logan,Naoml R Pappas,Christopher Wong,Wel Zhu,Noelwah Netusll,Joanna S. Fowler +9 more
TL;DR: Dopamine modulates motivation and reward circuits and hence dopamine deficiency in obese individuals may perpetuate pathological eating as a means to compensate for decreased activation of these circuits.
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Allelic discrimination using fluorogenic probes and the 5' nuclease assay.
TL;DR: The 5' nuclease (TaqMan) as discussed by the authors is a typical PCR that uses a fluorogenic probe, consisting of an oligonucleotide labeled with both a fluorescent reporter dye and a quencher dye.