Reward circuitry responsivity to food predicts future increases in body mass: moderating effects of DRD2 and DRD4.
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TLDR
This novel prospective fMRI study indicates that responsivity of reward circuitry to food increases risk for future weight gain, but that genes that impact dopamine signaling capacity moderate the predictive effects, suggesting two qualitatively distinct pathways to unhealthy weight gain based on genetic risk.About:
This article is published in NeuroImage.The article was published on 2010-05-01 and is currently open access. It has received 311 citations till now.read more
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Is obesity related to enhanced neural reactivity to visual food cues? A review and meta-analysis.
TL;DR: It is shown that age significantly influences brain response differences to food cues in the left insula and the left fusiform gyrus, and that such differences might be mediated by additional factors that are often not considered.
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Dopamine and food reward: Effects of acute tyrosine/phenylalanine depletion on appetite.
Charlotte A. Hardman,Vanessa M B Herbert,Jeffrey M. Brunstrom,Marcus R. Munafò,Peter J. Rogers +4 more
TL;DR: It is found that there is no evidence for compensatory eating following acute tyrosine/phenylalanine depletion and the results provide support for the role of dopamine in motivational components of eating.
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DRD2: Bridging the Genome and Ingestive Behavior.
TL;DR: The role of two common gene variants, FTO and TaqIA rs1800497, are considered in driving gene × environment interactions promoting obesity, metabolic dysfunction, and cognitive change via their influence on DA receptor subtype 2 (DRD2) signaling.
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Subtypes of trait impulsivity differentially correlate with neural responses to food choices
TL;DR: The brain mechanisms underlying subtypes of impulsivity have a common ground but differ in specific aspects of food-related decision-making, advancing the understanding of the neural correlates of different impulsivity subtypes in the food domain.
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Predictors of successful long-term weight loss maintenance: a two-year follow-up
Ryoko Sawamoto,Takehiro Nozaki,Tomoe Nishihara,Tomokazu Furukawa,Tomokazu Hata,Gen Komaki,Nobuyuki Sudo +6 more
TL;DR: It is suggested that larger weight reduction during the weight loss intervention and lower levels of disinhibition and food addiction at the end of the weight lost intervention predicted successful weight loss maintenance.
References
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Book
Applied Linear Statistical Models
TL;DR: Applied Linear Statistical Models 5e as discussed by the authors is the leading authoritative text and reference on statistical modeling, which includes brief introductory and review material, and then proceeds through regression and modeling for the first half, and through ANOVA and Experimental Design in the second half.
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Applied Linear Statistical Models
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Analysis of fMRI time-series revisited--again.
Keith J. Worsley,Karl J. Friston +1 more
TL;DR: Correct results are presented that replace those of the previous paper and solve the same problem without recourse to heuristic arguments and a proper and unbiased estimator for the error terms are introduced.
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Brain dopamine and obesity.
Gene-Jack Wang,Gene-Jack Wang,Nora D. Volkow,Nora D. Volkow,Jean Logan,Naoml R Pappas,Christopher Wong,Wel Zhu,Noelwah Netusll,Joanna S. Fowler +9 more
TL;DR: Dopamine modulates motivation and reward circuits and hence dopamine deficiency in obese individuals may perpetuate pathological eating as a means to compensate for decreased activation of these circuits.
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Allelic discrimination using fluorogenic probes and the 5' nuclease assay.
TL;DR: The 5' nuclease (TaqMan) as discussed by the authors is a typical PCR that uses a fluorogenic probe, consisting of an oligonucleotide labeled with both a fluorescent reporter dye and a quencher dye.