Reward circuitry responsivity to food predicts future increases in body mass: moderating effects of DRD2 and DRD4.
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TLDR
This novel prospective fMRI study indicates that responsivity of reward circuitry to food increases risk for future weight gain, but that genes that impact dopamine signaling capacity moderate the predictive effects, suggesting two qualitatively distinct pathways to unhealthy weight gain based on genetic risk.About:
This article is published in NeuroImage.The article was published on 2010-05-01 and is currently open access. It has received 311 citations till now.read more
Citations
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Journal ArticleDOI
Neural Vulnerability Factors That Predict Future Weight Gain.
Eric Stice,Sonja Yokum +1 more
TL;DR: In this article, the authors discuss five neural vulnerability theories for weight gain and review evidence from prospective studies using imaging and behavioral measures reflecting neural function, as well as randomized experiments with humans and animals that are consistent or inconsistent with these theories.
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Gender Differences in Risk Factors for Stice's Bulimia in a Non-Clinical Sample.
TL;DR: The results of this study fail to support the role of BMI as a predictor of dietary restraint in females, the main risk factor for eating disorders, regardless of their BMI.
Dissertation
The role of candidate gene x environment interactions in eating pathology: an investigation of the 5-HTTLPR polymorphism
TL;DR: Rozenblat et al. as mentioned in this paper presented an analysis of the relationship between psychology and mental health in the context of mental health disorders, and proposed a method to identify the root cause.
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Associations Between Exposure to Gestational Diabetes Mellitus In Utero and Daily Energy Intake, Brain Responses to Food Cues, and Adiposity in Children.
Shan Luo,Brendan Angelo,Ting Chow,John Monterosso,Paul M. Thompson,Anny H. Xiang,Kathleen A. Page +6 more
TL;DR: In this article, the authors examined the relationship between exposure to gestational diabetes mellitus (GDM) or maternal obesity in utero and daily energy intake (EI), brain responses to food cues within reward regions, and adiposity in children.
DissertationDOI
The relationship between eating behavior and psychological distress among overweight and obese people:is there a role for mindfulness?
TL;DR: The role of mindfulness and mindful eating as a potential mediator and moderator between overeating behavior (binge eating and emotional overeating) and negative outcomes (psychological distress, body dissatisfaction) was explored in this article.
References
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Book
Applied Linear Statistical Models
TL;DR: Applied Linear Statistical Models 5e as discussed by the authors is the leading authoritative text and reference on statistical modeling, which includes brief introductory and review material, and then proceeds through regression and modeling for the first half, and through ANOVA and Experimental Design in the second half.
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Applied Linear Statistical Models
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Analysis of fMRI time-series revisited--again.
Keith J. Worsley,Karl J. Friston +1 more
TL;DR: Correct results are presented that replace those of the previous paper and solve the same problem without recourse to heuristic arguments and a proper and unbiased estimator for the error terms are introduced.
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Brain dopamine and obesity.
Gene-Jack Wang,Gene-Jack Wang,Nora D. Volkow,Nora D. Volkow,Jean Logan,Naoml R Pappas,Christopher Wong,Wel Zhu,Noelwah Netusll,Joanna S. Fowler +9 more
TL;DR: Dopamine modulates motivation and reward circuits and hence dopamine deficiency in obese individuals may perpetuate pathological eating as a means to compensate for decreased activation of these circuits.
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Allelic discrimination using fluorogenic probes and the 5' nuclease assay.
TL;DR: The 5' nuclease (TaqMan) as discussed by the authors is a typical PCR that uses a fluorogenic probe, consisting of an oligonucleotide labeled with both a fluorescent reporter dye and a quencher dye.