Reward circuitry responsivity to food predicts future increases in body mass: moderating effects of DRD2 and DRD4.
Reads0
Chats0
TLDR
This novel prospective fMRI study indicates that responsivity of reward circuitry to food increases risk for future weight gain, but that genes that impact dopamine signaling capacity moderate the predictive effects, suggesting two qualitatively distinct pathways to unhealthy weight gain based on genetic risk.About:
This article is published in NeuroImage.The article was published on 2010-05-01 and is currently open access. It has received 311 citations till now.read more
Citations
More filters
Journal ArticleDOI
Developmental imaging genetics: Linking dopamine function to adolescent behavior
Aarthi Padmanabhan,Beatriz Luna +1 more
TL;DR: The use of imaging genetics is proposed to examine the influence of genetically mediated dopamine variability on brain function during adolescence, keeping in mind the limitations of this approach.
Journal ArticleDOI
Food-induced brain responses and eating behaviour.
Paul A.M. Smeets,Lisette Charbonnier,Floor van Meer,Laura N. van der Laan,Maartje S. Spetter +4 more
TL;DR: The current state of the field of ‘nutritional neuroscience’ is reviewed with a focus on the interplay between food-induced brain responses and eating behaviour and research needs and techniques that could be used to address these are highlighted.
Journal ArticleDOI
Metabolic vs. hedonic obesity: a conceptual distinction and its clinical implications
Y‐H. Yu,Y‐H. Yu,J. R. Vasselli,J. R. Vasselli,YW Zhang,J. I. Mechanick,J. Korner,J. Korner,Ralph Peterli +8 more
TL;DR: Recognition of the two types of obesity may lead to more effective treatment and prevention of obesity, which involves the active control of both food intake and energy expenditure.
Journal ArticleDOI
Negative affect and neural response to palatable food intake in bulimia nervosa
Cara Bohon,Eric Stice +1 more
TL;DR: Results show that as negative affect increases, so does responsivity of reward regions to anticipated intake of palatable food, implying thatnegative affect may increase the reward value of food for individuals with bulimia nervosa or that negative affect has become a conditioned cue due to a history of binge eating in a negative mood.
Journal ArticleDOI
Associations between depressive symptoms, self-efficacy, eating styles, exercise and body mass index in women.
TL;DR: The association between greater healthy eating self efficacy and BMI was unexpected, and may indicate a suppressor effect of eating self-efficacy in the relationship between depressive symptoms and BMI in women.
References
More filters
Book
Applied Linear Statistical Models
TL;DR: Applied Linear Statistical Models 5e as discussed by the authors is the leading authoritative text and reference on statistical modeling, which includes brief introductory and review material, and then proceeds through regression and modeling for the first half, and through ANOVA and Experimental Design in the second half.
Journal ArticleDOI
Applied Linear Statistical Models
Journal ArticleDOI
Analysis of fMRI time-series revisited--again.
Keith J. Worsley,Karl J. Friston +1 more
TL;DR: Correct results are presented that replace those of the previous paper and solve the same problem without recourse to heuristic arguments and a proper and unbiased estimator for the error terms are introduced.
Journal ArticleDOI
Brain dopamine and obesity.
Gene-Jack Wang,Gene-Jack Wang,Nora D. Volkow,Nora D. Volkow,Jean Logan,Naoml R Pappas,Christopher Wong,Wel Zhu,Noelwah Netusll,Joanna S. Fowler +9 more
TL;DR: Dopamine modulates motivation and reward circuits and hence dopamine deficiency in obese individuals may perpetuate pathological eating as a means to compensate for decreased activation of these circuits.
Journal ArticleDOI
Allelic discrimination using fluorogenic probes and the 5' nuclease assay.
TL;DR: The 5' nuclease (TaqMan) as discussed by the authors is a typical PCR that uses a fluorogenic probe, consisting of an oligonucleotide labeled with both a fluorescent reporter dye and a quencher dye.