Reward circuitry responsivity to food predicts future increases in body mass: moderating effects of DRD2 and DRD4.
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TLDR
This novel prospective fMRI study indicates that responsivity of reward circuitry to food increases risk for future weight gain, but that genes that impact dopamine signaling capacity moderate the predictive effects, suggesting two qualitatively distinct pathways to unhealthy weight gain based on genetic risk.About:
This article is published in NeuroImage.The article was published on 2010-05-01 and is currently open access. It has received 311 citations till now.read more
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“Liking” and “Wanting” Linked to Reward Deficiency Syndrome (RDS): Hypothesizing Differential Responsivity in Brain Reward Circuitry
TL;DR: The incentive salience or "wanting" hypothesis of DA function is supported by a majority of the evidence and the RDS model of etiology holds very well for a variety of chemical and behavioral addictions.
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Healthy diet: Health impact, prevalence, correlates, and interventions
Denise T. D. de Ridder,Floor M. Kroese,Catharine Evers,Marieke A. Adriaanse,Marleen Gillebaart +4 more
TL;DR: It is crucial to gain a better understanding of both the automatic and environmental influences that are responsible for people not acting upon their good intentions for diet change, as well as the psychological and environmental determinants of healthy diet.
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Neural Responses to Visual Food Cues According to Weight Status: A Systematic Review of Functional Magnetic Resonance Imaging Studies
Kirrilly M. Pursey,Peter Stanwell,Robert J. Callister,Katherine Emma Brain,Clare E. Collins,Tracy Burrows +5 more
TL;DR: Meta-analysis of changes in neural activation post-weight loss revealed small areas of convergence across studies in brain areas related to emotion, memory, and learning, including the cingulate gyrus, lentiform nucleus, and precuneus.
Neural correlates of the volitional regulation of the desire for food
Maurice Hollmann,Lydia Hellrung,Haiko Schlögl,Stefan Kabisch,Michael Stumvoll,Arno Villringer,Burkhard Pleger,Annette Horstmann +7 more
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Alterations of the salience network in obesity: A resting‐state fMRI study
Isabel García-García,María Ángeles Jurado,Maite Garolera,Bàrbara Segura,Roser Sala-Llonch,Idoia Marqués-Iturria,Roser Pueyo,María José Sender-Palacios,Maria Vernet-Vernet,Ana Narberhaus,Mar Ariza,Carme Junqué +11 more
TL;DR: Results showed that the functional connectivity strength of the putamen nucleus in the salience network was increased in the obese group, which is consistent with the notion that basal ganglia circuits modulate rapid processing of information.
References
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Book
Applied Linear Statistical Models
TL;DR: Applied Linear Statistical Models 5e as discussed by the authors is the leading authoritative text and reference on statistical modeling, which includes brief introductory and review material, and then proceeds through regression and modeling for the first half, and through ANOVA and Experimental Design in the second half.
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Applied Linear Statistical Models
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Analysis of fMRI time-series revisited--again.
Keith J. Worsley,Karl J. Friston +1 more
TL;DR: Correct results are presented that replace those of the previous paper and solve the same problem without recourse to heuristic arguments and a proper and unbiased estimator for the error terms are introduced.
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Brain dopamine and obesity.
Gene-Jack Wang,Gene-Jack Wang,Nora D. Volkow,Nora D. Volkow,Jean Logan,Naoml R Pappas,Christopher Wong,Wel Zhu,Noelwah Netusll,Joanna S. Fowler +9 more
TL;DR: Dopamine modulates motivation and reward circuits and hence dopamine deficiency in obese individuals may perpetuate pathological eating as a means to compensate for decreased activation of these circuits.
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Allelic discrimination using fluorogenic probes and the 5' nuclease assay.
TL;DR: The 5' nuclease (TaqMan) as discussed by the authors is a typical PCR that uses a fluorogenic probe, consisting of an oligonucleotide labeled with both a fluorescent reporter dye and a quencher dye.