Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19: a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK.
Chloe I Bloom,Thomas M Drake,Annemarie B Docherty,Brian J. Lipworth,Sebastian L. Johnston,Jonathan S. Nguyen-Van-Tam,Gail Carson,Jake Dunning,Jake Dunning,Ewen M Harrison,J Kenneth Baillie,Malcolm G Semple,Malcolm G Semple,Paul Cullinan,Peter J. M. Openshaw,Beatrice Alex,Benjamin Bach,Wendy S. Barclay,Debby Bogaert,Meera Chand,Graham S Cooke,Ana da Silva Filipe,Tom Fletcher,Christoper A Green,Julian A. Hiscox,Antonia Ying Ho,Peter Horby,Samreen Ijaz,Saye Khoo,Paul Klenerman,Andy Law,Wei Shen Lim,Alexander J. Mentzer,Laura Merson,Alison M. Meynert,Mahdad Noursadeghi,Shona C Moore,Massimo Palmarini,William A. Paxton,Georgios Pollakis,Nicholas Price,Andrew Rambaut,David Robertson,Clark D Russell,Vanessa Sancho-Shimizu,Janet T Scott,Thushan I de Silva,Louise Sigfrid,Tom Solomon,Shiranee Sriskandan,David I. Stuart,Charlotte Summers,Richard S. Tedder,E. Thomson,A. A. Roger Thompson,Ryan S Thwaites,Lance Turtle,Maria Zambon,Hayley E Hardwick,Chloe Donohue,Ruth Lyons,Fiona Griffiths,Wilna Oosthuyzen,Lisa Norman,Riinu Pius,Cameron J Fairfield,Stephen R Knight,Kenneth A. McLean,Derek Murphy,Catherine A Shaw,Jo Dalton,Michelle Girvan,Egle Saviciute,Stephanie Roberts,Janet Harrison,Laura Marsh,Marie Connor,Sophie Halpin,Clare Jackson,Carrol Gamble,Gary Leeming,Murray Wham,Sara Clohisey,Ross Hendry,James Scott-Brown,William Greenhalf,Victoria Shaw,Sara McDonald,Seán Keating,Katie A. Ahmed,Jane A Armstrong,Milton Ashworth,Innocent G Asiimwe,Siddharth Bakshi,Samantha L Barlow,Laura Booth,Benjamin Brennan,Katie Bullock,Benjamin Wa Catterall,Jordan J. Clark,Emily A Clarke,Sarah Cole,Louise Cooper,Helen Cox,Chris Davis,Oslem Dincarslan,Chris Dunn,P.A. Dyer,Angela Elliott,Anthony Evans,Lorna Finch,Lewis Ws Fisher,Terry Foster,Isabel García-Dorival,Philip Gunning,Catherine Hartley,Rebecca L Jensen,Christopher B Jones,Trevor R Jones,Shadia Khandaker,Katharine King,Robyn T. Kiy,Chrysa Koukorava,Annette Lake,Suzannah Lant,Diane Latawiec,Lara Lavelle-Langham,Daniella Lefteri,Lauren Lett,Lucia A Livoti,Maria Mancini,Sarah E. McDonald,Laurence McEvoy,John McLauchlan,Soeren Metelmann,Nahida S Miah,Joanna Middleton,Joyce Mitchell,Ellen G Murphy,Rebekah Penrice-Randal,Jack Pilgrim,Tessa Prince,Will Reynolds,P. Matthew Ridley,Debby Sales,Victoria E Shaw,Rebecca K Shears,Benjamin Small,Krishanthi Subramaniam,Agnieska Szemiel,Aislynn Taggart,Jolanta Tanianis-Hughes,Jordan Thomas,Erwan Trochu,Libby van Tonder,Eve Wilcock,J. Eunice Zhang,Lisa Flaherty,Nicole Maziere,Emily Cass,Alejandra Doce Carracedo,Nicola Carlucci,Anthony Holmes,Hannah Massey,Kayode Adeniji,Daniel Agranoff,Ken Agwuh,Dhiraj Ail,Ana Alegria,Brian Angus,Abdul Ashish,Dougal Atkinson,Shahedal Bari,Gavin Barlow,Stella Barnass,Nicholas A Barrett,Christopher Bassford,David Baxter,Michael Beadsworth,Jolanta Bernatoniene,John Berridge,Nicola Best,Pieter Bothma,David Brealey,Robin Brittain-Long,Naomi Bulteel,Tom Burden,Andrew Burtenshaw,Vikki Caruth,David Chadwick,Duncan Chambler,Nigel Chee,Jenny Child,Srikanth Chukkambotla,Thomas A. Clark,Paul Collini,Catherine Cosgrove,Jason Cupitt,Maria-Teresa Cutino-Moguel,Paul Dark,Chris Dawson,Samir Dervisevic,Phil Donnison,Sam Douthwaite,Ingrid DuRand,Ahilanadan Dushianthan,Tristan Dyer,Cariad Evans,Chi Eziefula,Chrisopher Fegan,Adam Finn,Duncan Fullerton,Sanjeev Garg,Atul Garg,Effrossyni Gkrania-Klotsas,Jo Godden,Arthur Goldsmith,Clive Graham,Elaine Hardy,Stuart Hartshorn,Daniel Harvey,Peter Havalda,Daniel B Hawcutt,Maria Hobrok,Luke Hodgson,Anil Hormis,Michael Jacobs,Susan Jain,Paul Jennings,Agilan Kaliappan,Vidya Kasipandian,Stephen Kegg,Michael Kelsey,Jason Kendall,Caroline Kerrison,Ian Kerslake,Oliver Koch,Gouri Koduri,George Koshy,Shondipon Laha,Steven Laird,Susan Larkin,Tamas Leiner,Patrick J. Lillie,James Limb,Vanessa Linnett,Jeff Little,Michael MacMahon,Emily MacNaughton,Ravish Mankregod,Huw Masson,Elijah Matovu,Katherine McCullough,Ruth McEwen,Manjula Meda,Gary H. Mills,Jane Minton,Mariyam Mirfenderesky,Kavya Mohandas,Quen Mok,James Moon,Elinoor Moore,Patrick Morgan,Craig Morris,Katherine Mortimore,Samuel Moses,Mbiye Mpenge,Rohinton Mulla,Michael Murphy,Megan Nagel,Thapas Nagarajan,Mark T. Nelson,Igor Otahal,Mark Pais,Selva Panchatsharam,Hassan Paraiso,Brij Patel,Natalie Pattison,Justin Pepperell,Mark J. Peters,Mandeep Phull,Stefania Pintus,Jagtur Singh Pooni,Frank A. Post,David Price,Rachel Prout,Nikolas Rae,Henrik Reschreiter,Tim Reynolds,Neil Richardson,Mark Roberts,Devender Roberts,Alistair Rose,Guy Rousseau,Brendan Ryan,Taranprit Saluja,Aarti Shah,Prad Shanmuga,Anil Sharma,Anna Shawcross,Jeremy Sizer,Manu Shankar-Hari,Richard Smith,Catherine Snelson,Nick Spittle,Nikki Staines,Tom Stambach,Richard Stewart,Pradeep Subudhi,Tamas Szakmany,Kate Tatham,Jo Thomas,Chris Thompson,Robert Thompson,Ascanio Tridente,Darell Tupper-Carey,Mary Twagira,Andrew Ustianowski,Nick Vallotton,Lisa Vincent-Smith,Shico Visuvanathan,Alan Vuylsteke,Sam Waddy,Rachel Wake,Andrew Walden,Ingeborg Welters,Tony Whitehouse,Paul Whittaker,Ashley Whittington,Meme Wijesinghe,Martin S. Williams,Lawrence Wilson,Sarah Wilson,Stephen Winchester,Martin Wiselka,Adam Wolverson,Daniel G Wooton,Andrew Workman,Bryan Yates,Peter Young +339 more
TLDR
In this paper, the effect of inhaled corticosteroid use in patients admitted to hospital with COVID-19 with underlying respiratory conditions was examined. But, the results were limited to patients aged 50 years and older and not for those with chronic pulmonary disease.About:
This article is published in The Lancet Respiratory Medicine.The article was published on 2021-03-04 and is currently open access. It has received 109 citations till now. The article focuses on the topics: Asthma & Respiratory disease.read more
Citations
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Inhaled budesonide in the treatment of early COVID-19 (STOIC): a phase 2, open-label, randomised controlled trial.
Sanjay Ramakrishnan,Sanjay Ramakrishnan,Sanjay Ramakrishnan,Dan V. Nicolau,Dan V. Nicolau,Dan V. Nicolau,Beverly Langford,Beverly Langford,Mahdi Mahdi,Mahdi Mahdi,Helen Jeffers,Helen Jeffers,Christine Mwasuku,Christine Mwasuku,Karolina Krassowska,Karolina Krassowska,Robin Fox,Ian Binnian,Victoria Glover,Stephen Bright,Christopher C Butler,Jennifer L Cane,Jennifer L Cane,Andreas Halner,Philippa C Matthews,Philippa C Matthews,Louise E. Donnelly,Jodie L. Simpson,Jonathan R. Baker,Nabil T. Fadai,Stefan Peterson,Thomas Bengtsson,Peter J. Barnes,Richard Russell,Richard Russell,Mona Bafadhel,Mona Bafadhel +36 more
TL;DR: In this paper, an open-label, parallel-group, phase 2, randomised controlled trial (Steroids in COVID-19; STOIC) of inhaled budesonide, compared with usual care, in adults within 7 days of the onset of mild COPD symptoms was performed in the community in Oxfordshire, UK.
Journal ArticleDOI
Chronic respiratory diseases are predictors of severe outcome in COVID-19 hospitalised patients: a nationwide study.
Guillaume Beltramo,Jonathan Cottenet,Anne-Sophie Mariet,Marjolaine Georges,Lionel Piroth,Pascale Tubert-Bitter,Philippe Bonniaud,Catherine Quantin +7 more
TL;DR: In this article, a nationwide retrospective cohort study describes patients with prior lung disease hospitalised for COVID-19 (March-April 2020) or influenza (2018-2019 influenza outbreak).
Journal ArticleDOI
Asthma phenotypes, associated comorbidities, and long-term symptoms in COVID-19.
Lauren E. Eggert,Ziyuan He,William Collins,Alexandra S. Lee,Gopal Krishna R. Dhondalay,Shirley Y. Jiang,Jessica Fitzpatrick,Theo T Snow,Benjamin A. Pinsky,Maja Artandi,Linda Barman,Rajan Puri,Richard Wittman,Neera Ahuja,Andra L. Blomkalns,Ruth O'Hara,Shu Cao,Manisha Desai,Sayantani B. Sindher,Kari C. Nadeau,R. Sharon Chinthrajah +20 more
TL;DR: Asthma is not a risk factor for more severe COVID-19 disease and allergic asthmatics were half as likely to be hospitalized with CO VID-19 compared to non-allergic astHmatics, and lower levels of eosinophil counts (allergic biomarkers) were associated with a more severeCOVID- 19 disease trajectory.
Journal ArticleDOI
COVID-19 risk and outcomes in adult asthmatic patients treated with biologics or systemic corticosteroids: Nationwide real-world evidence.
TL;DR: In this article, the association between biologics or systemic corticosteroids use and PCR positivity for SARS-CoV-2 and coronavirus disease 2019 (COVID-19) outcomes among asthmatic patients was determined.
Journal ArticleDOI
Advances and highlights in asthma in 2021.
Ioana Agache,Ibon Eguiluz-Gracia,Catalina Cojanu,Alexandru Laculiceanu,Stefano Del Giacco,Magdalena Zemelka-Wiacek,Anna Kosowska,Cezmi A. Akdis,Marek Jutel +8 more
TL;DR: A review of recent published articles and clinical trials with the goal to provide clinicians and researchers with a concise update on asthma research from a translational perspective is presented in this article. But, the authors do not discuss the use of artificial intelligence in the diagnosis and treatment of asthma.
References
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Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.
Dawei Wang,Bo Hu,Chang Hu,Fangfang Zhu,Xing Liu,Jing Zhang,Binbin Wang,Hui Xiang,Zhenshun Cheng,Yong Xiong,Yan Zhao,Yirong Li,Xinghuan Wang,Zhiyong Peng +13 more
TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.
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Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area.
Safiya Richardson,Safiya Richardson,Jamie S. Hirsch,Jamie S. Hirsch,Mangala Narasimhan,James M. Crawford,Thomas McGinn,Thomas McGinn,Karina W. Davidson,Karina W. Davidson,Douglas P. Barnaby,Douglas P. Barnaby,Lance B Becker,John Chelico,John Chelico,Stuart L. Cohen,Stuart L. Cohen,Jennifer Cookingham,Kevin Coppa,Michael A Diefenbach,Andrew J. Dominello,Joan Duer-Hefele,Louise Falzon,Jordan Gitlin,Negin Hajizadeh,Negin Hajizadeh,Tiffany G. Harvin,David Hirschwerk,Eun Ji Kim,Eun Ji Kim,Zachary Kozel,Lyndonna Marrast,Lyndonna Marrast,Jazmin N. Mogavero,Gabrielle A. Osorio,Michael Qiu,Theodoros P. Zanos +36 more
TL;DR: This case series provides characteristics and early outcomes of sequentially hospitalized patients with confirmed COVID-19 in the New York City area and assesses outcomes during hospitalization, such as invasive mechanical ventilation, kidney replacement therapy, and death.
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Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy.
Giacomo Grasselli,Giacomo Grasselli,Alberto Zangrillo,Alberto Zanella,Alberto Zanella,Massimo Antonelli,Massimo Antonelli,Luca Cabrini,Antonio Castelli,Danilo Cereda,Antonio Coluccello,Giuseppe Foti,Roberto Fumagalli,Giorgio Antonio Iotti,Nicola Latronico,Luca Lorini,Stefano Merler,Giuseppe Natalini,Alessandra Piatti,Marco Ranieri,Anna Mara Scandroglio,Enrico Storti,Maurizio Cecconi,Antonio Pesenti,Antonio Pesenti +24 more
TL;DR: Patients with coronavirus disease 2019 (COVID-19) requiring treatment in an intensive care unit (ICU) in the Lombardy region of Italy were characterized, including data on clinical management, respiratory failure, and patient mortality.
Journal ArticleDOI
Factors associated with COVID-19-related death using OpenSAFELY.
Elizabeth A. Williamson,Alex J Walker,Krishnan Bhaskaran,Seb Bacon,Chris Bates,Caroline E Morton,Helen J Curtis,Amir Mehrkar,David M. Evans,Peter Inglesby,Jonathan Cockburn,Helen Mcdonald,Brian MacKenna,Laurie A. Tomlinson,Ian J. Douglas,Christopher T Rentsch,Rohini Mathur,Angel Y S Wong,Richard Grieve,David G. Harrison,Harriet Forbes,Anna Schultze,Richard Croker,John Parry,Frank Hester,Sam Harper,Rafael Perera,Stephen J. W. Evans,Liam Smeeth,Ben Goldacre +29 more
TL;DR: A range of clinical factors associated with COVID-19-related death is quantified in one of the largest cohort studies on this topic so far and includes people of white ethnicity, Black and South Asian people were at higher risk, even after adjustment for other factors.
Journal ArticleDOI
Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study.
Annemarie B Docherty,Ewen M Harrison,Christopher A Green,Hayley E Hardwick,Riinu Pius,Lisa Norman,Karl A Holden,Jonathan M. Read,Frank Dondelinger,Gail Carson,Laura Merson,James A. Lee,Daniel Plotkin,Louise Sigfrid,Sophie Halpin,Clare Jackson,Carrol Gamble,Peter Horby,Jonathan S. Nguyen-Van-Tam,Antonia Ho,Clark D Russell,Jake Dunning,Jake Dunning,Peter J. M. Openshaw,J Kenneth Baillie,Malcolm G Semple +25 more
TL;DR: In study participants, mortality was high, independent risk factors were increasing age, male sex, and chronic comorbidity, including obesity, and the importance of pandemic preparedness and the need to maintain readiness to launch research studies in response to outbreaks is shown.
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