Role of Inflammatory Cytokines in COVID-19 Patients: A Review on Molecular Mechanisms, Immune Functions, Immunopathology and Immunomodulatory Drugs to Counter Cytokine Storm
Ali A. Rabaan,Shamsah H. Al-Ahmed,Javed Muhammad,Amjad Khan,Anupam A Sule,Raghavendra Tirupathi,Abbas Al Mutair,Saad Alhumaid,Awad Al-Omari,Manish Dhawan,Ruchi Tiwari,Khan Sharun,Ranjan K. Mohapatra,Saikat Mitra,Muhammad Bilal,Salem A. Alyami,Talha Bin Emran,Mohammad Ali Moni,Kuldeep Dhama +18 more
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This article is published in Vaccine.The article was published on 2021-04-29 and is currently open access. It has received 109 citations till now. The article focuses on the topics: Cytokine storm & Immunopathology.read more
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Viral Dynamics and Real-Time RT-PCR Ct Values Correlation with Disease Severity in COVID-19
Ali A. Rabaan,Raghavendra Tirupathi,Anupam A Sule,Jehad Aldali,Abbas Al Mutair,Saad Alhumaid,Muzaheed,Nitin Gupta,Thoyaja Koritala,Ramesh Adhikari,Muhammad Bilal,Manish Dhawan,Ruchi Tiwari,Saikat Mitra,Talha Bin Emran,Kuldeep Dhama +15 more
TL;DR: In this article, a review of the literature has been conducted to fill the knowledge gaps regarding the correlations between cycle threshold (Ct) values and severity/fatality rates of patients with COVID-19.
Journal ArticleDOI
Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19.
Felice D’Agnillo,Kathie-Anne Walters,Yongli Xiao,Zong-Mei Sheng,Kelsey Scherler,Jae-Keun Park,Sebastian Gygli,Luz Angela Rosas,Kaitlyn Sadtler,Heather Kalish,Charles Blatti,Ruoqing Zhu,Lisa Gatzke,Colleen Bushell,Matthew J. Memoli,Steven J. O'Day,Trevan D Fischer,Terese C. Hammond,Raymond Lee,J. Christian Cash,Matthew E Powers,Grant E. O'Keefe,Kelly J. Butnor,Amy Rapkiewicz,William D. Travis,Scott P Layne,John C. Kash,Jeffery K. Taubenberger +27 more
Journal ArticleDOI
Global emerging Omicron variant of SARS-CoV-2: Impacts, challenges and strategies
Kuldeep Dhama,Firzan Nainu,Andri Frediansyah,Mohd Iqbal Yatoo,Ranjan K. Mohapatra,Subrata Chakraborty,Hao Zhou,Md. Rabiul Islam,Sukamto S. Mamada,Hendrix Indra Kusuma,Ali A. Rabaan,Saad Alhumaid,Abbas Al Mutair,Muhammad Iqhrammullah,Jaffar A. Al-Tawfiq,Mohammed Al mohaini,A. Alsalman,Hardeep Singh Tuli,Chiranjib Chakraborty,Harapan Harapan +19 more
TL;DR: A review on the emerging SARS-CoV-2 variants with a special focus on the Omicron variant, its lineages and hybrid variants is presented in this paper .
Journal ArticleDOI
Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets.
Masoumeh Farahani,Zahra Niknam,Leila Mohammadi Amirabad,Nasrin Amiri-Dashatan,Mehdi Koushki,Mohadeseh Nemati,Fahima Danesh Pouya,Mostafa Rezaei-Tavirani,Yousef Rasmi,Lobat Tayebi +9 more
TL;DR: In this article, a review of the possible mechanisms of the host response following SARS-CoV-2 infection and surveyed current research conducted by in-vitro, in vivo and human observations, as well as existing suggestions.
Journal ArticleDOI
Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets
TL;DR: In this paper , a review of the possible mechanisms of the host response following SARS-CoV-2 infection and surveyed current research conducted by in vitro, in vivo and human observations, as well as existing suggestions.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
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Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.
Dawei Wang,Bo Hu,Chang Hu,Fangfang Zhu,Xing Liu,Jing Zhang,Binbin Wang,Hui Xiang,Zhenshun Cheng,Yong Xiong,Yan Zhao,Yirong Li,Xinghuan Wang,Zhiyong Peng +13 more
TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.
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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
TL;DR: It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.
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COVID-19: consider cytokine storm syndromes and immunosuppression
Puja Mehta,Daniel F. McAuley,Michael Brown,Emilie Sanchez,Rachel Tattersall,Rachel Tattersall,Jessica J Manson +6 more
TL;DR: Re-analysis of data from a phase 3 randomised controlled trial of IL-1 blockade (anakinra) in sepsis, showed significant survival benefit in patients with hyperinflammation, without increased adverse events.
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Pathological findings of COVID-19 associated with acute respiratory distress syndrome.
Zhe Xu,Lei Shi,Yijin Wang,Ji-Yuan Zhang,Lei Huang,Chao Zhang,Shuhong Liu,Peng Zhao,Hongxia Liu,Li Zhu,Yanhong Tai,Changqing Bai,Tingting Gao,Jin-Wen Song,Peng Xia,Jing-Hui Dong,Jingmin Zhao,Fu-Sheng Wang +17 more
TL;DR: O surto do novo coronavÃrus (COVID-19) em Wuhan, China, iniciado em dezembro de 2019, evoluiu para se tornar uma pandemia global A.
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