SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma
Constantinos Kurt Wibmer,Frances Ayres,Tandile Hermanus,Mashudu Madzivhandila,Prudence Kgagudi,Brent Oosthuysen,Bronwen E. Lambson,Bronwen E. Lambson,Tulio de Oliveira,Marion Vermeulen,Karin van der Berg,Karin van der Berg,Theresa M. Rossouw,Michael T. Boswell,Veronica Ueckermann,Susan Meiring,Anne von Gottberg,Anne von Gottberg,Cheryl Cohen,Cheryl Cohen,Lynn Morris,Lynn Morris,Jinal N. Bhiman,Jinal N. Bhiman,Penny L. Moore,Penny L. Moore +25 more
TLDR
SARS-CoV-2 501Y.V2 (B.1.351), a lineage of coronavirus causing COVID-19, contains substitutions in two immunodominant domains of the spike protein this article.Abstract:
SARS-CoV-2 501Y.V2 (B.1.351), a novel lineage of coronavirus causing COVID-19, contains substitutions in two immunodominant domains of the spike protein. Here, we show that pseudovirus expressing 501Y.V2 spike protein completely escapes three classes of therapeutically relevant antibodies. This pseudovirus also exhibits substantial to complete escape from neutralization, but not binding, by convalescent plasma. These data highlight the prospect of reinfection with antigenically distinct variants and foreshadows reduced efficacy of spike-based vaccines.read more
Citations
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Increased Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7 to Antibody Neutralization
Pengfei Wang,Manoj S. Nair,Lihong Liu,Sho Iketani,Sho Iketani,Yang Luo,Yicheng Guo,Maple Wang,Jian Yu,Baoshan Zhang,Peter D. Kwong,Peter D. Kwong,Barney S. Graham,John R. Mascola,Jennifer Y Chang,Jennifer Y Chang,Michael T. Yin,Michael T. Yin,Magdalena E. Sobieszczyk,Magdalena E. Sobieszczyk,Christos A. Kyratsous,Lawrence Shapiro,Lawrence Shapiro,Zizhang Sheng,Yaoxing Huang,David D. Ho,David D. Ho +26 more
TL;DR: In this paper, the authors report that B.1.7 is refractory to neutralization by most mAbs to the N-terminal domain (NTD) of spike and relatively resistant to a number of mabs to the receptor-binding domain (RBD).
Journal ArticleDOI
Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K and N501Y variants by BNT162b2 vaccine-elicited sera.
Xuping Xie,Yang Liu,Jianying Liu,Xianwen Zhang,Jing Zou,Camila R. Fontes-Garfias,Hongjie Xia,Kena A. Swanson,Mark Cutler,David A. Cooper,Vineet D. Menachery,Scott C. Weaver,Philip R. Dormitzer,Pei Yong Shi +13 more
TL;DR: In this paper, three severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses containing key spike mutations from the newly emerged United Kingdom (UK) and South African (SA) variants: N501Y from UK and SA; 69/70 deletion + N 501Y+D614G from UK; and E484K from SA.
Posted ContentDOI
mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants
Zijun Wang,Fabian Schmidt,Yiska Weisblum,Frauke Muecksch,Christopher O. Barnes,Shlomo Finkin,Dennis Schaefer-Babajew,Melissa Cipolla,Christian Gaebler,Jenna Ariel Lieberman,Thiago Y. Oliveira,Zhi Yang,Morgan E. Abernathy,Kathryn E. Huey-Tubman,Arlene Hurley,Martina Turroja,Kamille A. West,Kristie Gordon,Katrina G. Millard,Victor A. Ramos,Justin Da Silva,Jianliang Xu,Robert A. Colbert,Roshni Patel,Juan Dizon,Cecille Unson-O'Brien,Irina Shimeliovich,Anna Gazumyan,Marina Caskey,Pamela J. Bjorkman,Rafael Casellas,Theodora Hatziioannou,Paul D. Bieniasz,Paul D. Bieniasz,Michel C. Nussenzweig,Michel C. Nussenzweig +35 more
TL;DR: In this paper, the antibody and memory B cell responses in a cohort of 20 volunteers who received either the Moderna (mRNA-1273) or Pfizer-BioNTech (BNT162b2) vaccines were reported.
Journal ArticleDOI
SARS-CoV-2 Variants of Concern in the United States-Challenges and Opportunities.
Journal ArticleDOI
Genomic characterization of a novel SARS-CoV-2 lineage from Rio de Janeiro, Brazil.
Carolina M. Voloch,Ronaldo da Silva Francisco,Luiz Gonzaga Paula de Almeida,Cynthia Chester Cardoso,Otávio J. B. Brustolini,Alexandra L. Gerber,Ana Paula de C Guimarães,Diana Mariani,Raissa Mirella da Costa,Orlando C. Ferreira,Thiago Silva Frauches,Claudia Maria Braga de Mello,Isabela de Carvalho Leitão,Rafael Mello Galliez,Débora S. Faffe,Terezinha M. P. P. Castineiras,Amilcar Tanuri,Ana Tereza Ribeiro de Vasconcelos +17 more
TL;DR: In this article, the emergence of novel SARS-CoV-2 lineages characterized by their phylogenetic and genetic distinction was reported, and several studies reported that these lineages can be classified into two groups.
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