Separate and combined associations of obesity and metabolic health with coronary heart disease: a pan-European case-cohort analysis.
Camille Lassale,Camille Lassale,Ioanna Tzoulaki,Ioanna Tzoulaki,Karel G.M. Moons,Michael J. Sweeting,Jolanda M. A. Boer,Laura Johnson,José María Huerta,Claudia Agnoli,Heinz Freisling,Elisabete Weiderpass,Patrik Wennberg,Daphne L. van der A,Larraitz Arriola,Vassiliki Benetou,Heiner Boeing,Fabrice Bonnet,Fabrice Bonnet,Sandra Colorado-Yohar,Gunnar Engström,Anne Kirstine Eriksen,Pietro Ferrari,Sara Grioni,Matthias Johansson,Rudolf Kaaks,Michail Katsoulis,Verena Katzke,Timothy J. Key,Giuseppe Matullo,Olle Melander,Elena Molina-Portillo,Elena Molina-Portillo,Concepción Moreno-Iribas,Margareta Norberg,Kim Overvad,Kim Overvad,Salvatore Panico,J. Ramón Quirós,Calogero Saieva,Guri Skeie,Annika Steffen,Magdalena Stepien,Anne Tjønneland,Antonia Trichopoulou,Rosario Tumino,Yvonne T. van der Schouw,W M Monique Verschuren,Claudia Langenberg,Emanuele Di Angelantonio,Emanuele Di Angelantonio,Elio Riboli,Nicholas J. Wareham,John Danesh,John Danesh,John Danesh,Adam S. Butterworth,Adam S. Butterworth +57 more
TLDR
Irrespective of BMI, metabolically unhealthy individuals had higher CHD risk than their healthy counterparts and population-wide strategies to tackle obesity are challenged, challenging the concept of 'metabolically healthy obesity.Abstract:
EPIC-CVD has been supported by the European Union Framework 7 (HEALTH-F2-2012-279233), the European Research Council (268834), the UK Medical Research Council (G0800270 and MR/L003120/1), the British Heart Foundation (SP/09/002 and RG/08/014 and RG13/13/30194), and the UK National Institute of Health Research. EPIC Asturias was also supported by the Regional Government of Asturias. EPIC-Greece is also supported by the Hellenic Health Foundation. EPIC- Heidelberg was also supported by the German Cancer Aid, German Cancer Research Centre, German Federal Ministry of Education and Research. EPIC-Oxford was also supported by the UK Medical Research Council (MR/M012190/1) and Cancer Research UK (570/A16491). EPIC-Ragusa was also supported by the Sicilian Government, AIRE ONLUS Ragusa, and AVIS Ragusa. EPIC-Turin was supported also by the Compagnia di San Paolo and the Human Genetics Foundation-Torino (HuGeF).read more
Citations
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Journal ArticleDOI
A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement.
Mohammed Eslam,Philip N. Newsome,Shiv Kumar Sarin,Quentin M. Anstee,Giovanni Targher,Manuel Romero-Gómez,Shira Zelber-Sagi,Vincent Wai-Sun Wong,Jean-François Dufour,Jörn M. Schattenberg,Takumi Kawaguchi,Marco Arrese,Luca Valenti,Gamal Shiha,Claudio Tiribelli,Hannele Yki-Järvinen,Jian-Gao Fan,Henning Grønbæk,Yusuf Yilmaz,Helena Cortez-Pinto,Claudia P. Oliveira,Pierre Bedossa,Leon A. Adams,Ming-Hua Zheng,Yasser Fouad,Wah-Kheong Chan,Nahum Méndez-Sánchez,Sang Hoon Ahn,Laurent Castera,Elisabetta Bugianesi,Vlad Ratziu,Jacob George +31 more
TL;DR: A panel of international experts from 22 countries propose a new definition of metabolic-dysfunction-associated fatty liver disease that is both comprehensive yet simple for the diagnosis of MAFLD and is independent of other liver diseases.
Journal ArticleDOI
MAFLD: A Consensus-Driven Proposed Nomenclature for Metabolic Associated Fatty Liver Disease.
TL;DR: Experts reached consensus that NAFLD does not reflect current knowledge and metabolic (dysfunction) associated fatty liver disease "MAFLD" was suggested as a more appropriate overarching term and opens the door for efforts from the research community to update the nomenclature and sub-phenotype the disease in order to accelerate the translational path to new treatments.
Journal ArticleDOI
Obesity and Cardiovascular Disease: A Scientific Statement From the American Heart Association
Tiffany M. Powell-Wiley,Paul Poirier,Lora E. Burke,Jean-Pierre Després,Penny Gordon-Larsen,Carl J. Lavie,Scott A. Lear,Chiadi E Ndumele,Ian J. Neeland,Prashanthan Sanders,Marie-Pierre St-Onge +10 more
TL;DR: In this paper, the authors summarized the impact of obesity on the diagnosis, clinical management, and outcomes of atherosclerotic cardiovascular disease, heart failure, and arrhythmias, especially sudden cardiac death and atrial fibrillation.
Journal ArticleDOI
Cardiovascular and Metabolic Heterogeneity of Obesity: Clinical Challenges and Implications for Management.
TL;DR: Lifestyle, pharmacological, and surgical interventions allow a multidisciplinary approach to overweight/obesity that may improve outcomes and align with a public health message to combat the growing epidemic of obesity worldwide and to build healthier lives free of cardiovascular diseases.
Journal ArticleDOI
Causes, consequences, and treatment of metabolically unhealthy fat distribution.
TL;DR: Support is provided for the theory that a lower amount of lower-body fat mass is equally important to a high amount of visceral fat mass as a determinant of cardiometabolic diseases.
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