Similarity of mouse perivascular and brown adipose tissues and their resistance to diet-induced inflammation
Timothy P. Fitzgibbons,Sophia Kogan,Myriam Aouadi,Gregory M. Hendricks,Juerg R. Straubhaar,Michael P. Czech +5 more
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In this article, perivascular adipose tissue (PVAT) is a unique adipose depot that likely influences vascular function and susceptibility to pathogenesis in obesity and metabolic syndrome.Abstract:
Thoracic perivascular adipose tissue (PVAT) is a unique adipose depot that likely influences vascular function and susceptibility to pathogenesis in obesity and the metabolic syndrome. Surprisingly...read more
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The Influence of Ambient Temperature on Adipose Tissue Homeostasis, Metabolic Diseases and Cancers
TL;DR: In this paper , the authors discuss how adipose tissue responds to housing temperature and the outcomes of the thermoneutral (TN) zone in metabolic disease studies and highlight the critical role of TN housing in mouse models for studying adipose tissues function and human metabolic diseases.
Dissertation
Immunomodulatory Pathways and Metabolism
TL;DR: The role of metabolic regulators in the macrophage is discussed and it is shown that lipid sensing nuclear receptors, such as Pparδ and Pparγ, are critical regulators of phagosomal function and bacterial killing.
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The quantity and quality of cardiovascular fat at mid-life and future cognitive performance among women: The SWAN cardiovascular fat ancillary study.
Mei-hua Qi,Ian Janssen,Emma Barinas-Mitchell,Matthew J. Budoff,Maria M. Brooks,Arun S. Karlamangla,Carol A. Derby,Chung-Chou H. Chang,Kelly J. Shields,Samar R. El Khoudary +9 more
TL;DR: In this article , the associations of cardiovascular fat (including epicardial, paracardial and thoracic perivascular adipose tissue [PVAT]) quantity and quality assessed at mean age of 51 with subsequent cognitive performance measured repeatedly over 16 years of follow-up were examined using mixed models among 531 women.
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Assessing Genetic Diversity and Searching for Selection Signatures by Comparison between the Indigenous Livni and Duroc Breeds in Local Livestock of the Central Region of Russia
Irina M. Chernukha,Alexandra S Abdelmanova,Elena Kotenkova,V. R. Kharzinova,Natalia A Zinovieva +4 more
TL;DR: In this paper , a comparative study of two pig breeds with different breeding histories and breeding objectives, i.e., the native fat-type Livni and meat-type Duroc breeds using the Porcine GGP HD BeadChip, was conducted.
References
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Analysis of relative gene expression data using real-time quantitative pcr and the 2(-delta delta c(t)) method
TL;DR: The 2-Delta Delta C(T) method as mentioned in this paper was proposed to analyze the relative changes in gene expression from real-time quantitative PCR experiments, and it has been shown to be useful in the analysis of realtime, quantitative PCR data.
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Bioconductor: open software development for computational biology and bioinformatics
Robert Gentleman,Vincent J. Carey,Douglas M. Bates,Benjamin M. Bolstad,Marcel Dettling,Sandrine Dudoit,Byron Ellis,Laurent Gautier,Yongchao Ge,Jeff Gentry,Kurt Hornik,Torsten Hothorn,Wolfgang Huber,Stefano Maria Iacus,Rafael A. Irizarry,Friedrich Leisch,Cheng Li,Martin Maechler,A. J. Rossini,Günther Sawitzki,Colin A. Smith,Gordon K. Smyth,Luke Tierney,Jean Yang,Jianhua Zhang +24 more
TL;DR: Details of the aims and methods of Bioconductor, the collaborative creation of extensible software for computational biology and bioinformatics, and current challenges are described.
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Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
TL;DR: The Gene Expression Omnibus (GEO) project was initiated in response to the growing demand for a public repository for high-throughput gene expression data and provides a flexible and open design that facilitates submission, storage and retrieval of heterogeneous data sets from high-power gene expression and genomic hybridization experiments.
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A comparison of normalization methods for high density oligonucleotide array data based on variance and bias
TL;DR: Three methods of performing normalization at the probe intensity level are presented: a one number scaling based algorithm and a method that uses a non-linear normalizing relation by comparing the variability and bias of an expression measure and the simplest and quickest complete data method is found to perform favorably.
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Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance.
Haiyan Xu,Glenn Barnes,Qing Yang,Guo Tan,Daseng Yang,Chieh J. Chou,Jason Sole,Andrew Nichols,Jeffrey S. Ross,Louis A. Tartaglia,Hong Chen +10 more
TL;DR: It is proposed that obesity-related insulin resistance is, at least in part, a chronic inflammatory disease initiated in adipose tissue, and that macrophage-related inflammatory activities may contribute to the pathogenesis of obesity-induced insulin resistance.