Similarity of mouse perivascular and brown adipose tissues and their resistance to diet-induced inflammation
Timothy P. Fitzgibbons,Sophia Kogan,Myriam Aouadi,Gregory M. Hendricks,Juerg R. Straubhaar,Michael P. Czech +5 more
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TLDR
In this article, perivascular adipose tissue (PVAT) is a unique adipose depot that likely influences vascular function and susceptibility to pathogenesis in obesity and metabolic syndrome.Abstract:
Thoracic perivascular adipose tissue (PVAT) is a unique adipose depot that likely influences vascular function and susceptibility to pathogenesis in obesity and the metabolic syndrome. Surprisingly...read more
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Naïve, Regulatory, Activated, and Memory Immune Cells Co-exist in PVATs That Are Comparable in Density to Non-PVAT Fats in Health.
TL;DR: Overall, this research for the first time has identified a community of discrete populations of immune cells (naive/recently activated/regulatory/memory) in healthy PVATs.
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Aerobic exercise promotes the functions of brown adipose tissue in obese mice via a mechanism involving COX2 in the VEGF signaling pathway
Pengyu Fu,Rongxin Zhu,Jie Jia,Yang Hu,Chengjun Wu,Paweł Cięszczyk,Hans-Christer Holmberg,Gong Lijing +7 more
TL;DR: In this paper, the authors found that four weeks of aerobic exercise increased BAT mass and increased the expression of genes related to glycolipid metabolism and anti-inflammatory processes, with COX2 in the VEGF signaling pathway playing a key role.
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Site-specific impairment of perivascular adipose tissue on advanced atherosclerotic plaques using multimodal nonlinear optical imaging
TL;DR: PVAT changes differentially from the initial stages to advanced stages of atherosclerosis and undergoes spatial impairment focused on atherosclerotic plaques, providing a new concept of PVAT as modulating a direct interaction between the adipose tissue and cardiovascular system.
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Inflammation in Metabolic and Cardiovascular Disorders-Role of Oxidative Stress.
TL;DR: In this article, the activation of immune cells in the context of ROS production, as well as how their interaction with other cellular players and further (immune) mediators contribute to metabolic and cardiovascular disorders.
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Adipose Tissue and Modulation of Hypertension.
TL;DR: New insights on WAT browning and BAT activation can open new avenues of potential therapeutic interventions to treat obesity-related HTN.
References
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Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance.
Haiyan Xu,Glenn Barnes,Qing Yang,Guo Tan,Daseng Yang,Chieh J. Chou,Jason Sole,Andrew Nichols,Jeffrey S. Ross,Louis A. Tartaglia,Hong Chen +10 more
TL;DR: It is proposed that obesity-related insulin resistance is, at least in part, a chronic inflammatory disease initiated in adipose tissue, and that macrophage-related inflammatory activities may contribute to the pathogenesis of obesity-induced insulin resistance.