Similarity of mouse perivascular and brown adipose tissues and their resistance to diet-induced inflammation
Timothy P. Fitzgibbons,Sophia Kogan,Myriam Aouadi,Gregory M. Hendricks,Juerg R. Straubhaar,Michael P. Czech +5 more
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In this article, perivascular adipose tissue (PVAT) is a unique adipose depot that likely influences vascular function and susceptibility to pathogenesis in obesity and metabolic syndrome.Abstract:
Thoracic perivascular adipose tissue (PVAT) is a unique adipose depot that likely influences vascular function and susceptibility to pathogenesis in obesity and the metabolic syndrome. Surprisingly...read more
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Decrease of Perivascular Adipose Tissue Browning Is Associated With Vascular Dysfunction in Spontaneous Hypertensive Rats During Aging.
TL;DR: Ageing is associated with a decrease of tPVAT browning and adenosine production in SHR rats, which may result in attenuated vasodilation effect of the tPvAT inSHR during aging.
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Changes in brown adipose tissue lipid mediator signatures with aging, obesity, and DHA supplementation in female mice.
Elisa Félix-Soriano,Neira Sáinz,Eva Gil-Iturbe,María Collantes,Marta Fernández-Galilea,Rosa Castilla-Madrigal,Lucy Ly,Jesmond Dalli,María J. Moreno-Aliaga +8 more
TL;DR: In this paper, the changes in BAT SPMs signatures and their association with BAT dysfunction during aging, especially under obesogenic conditions, and their modulation by a docosahexaenoic acid (DHA)-rich diet.
Journal ArticleDOI
Deletion of UCP1 enhances ex vivo aortic vasomotor function in female but not male mice despite similar susceptibility to metabolic dysfunction.
Nathan C. Winn,Zachary I. Grunewald,Michelle L. Gastecki,Makenzie L Woodford,Rebecca J. Welly,Stephanie L Clookey,James R. Ball,T’Keaya L. Gaines,Natalia G. Karasseva,Jill A. Kanaley,Harold S. Sacks,Victoria J. Vieira-Potter,Jaume Padilla +12 more
TL;DR: Females are typically more insulin sensitive than males, which may be partly attributed to greater brown adipose tissue (BAT) activity and uncoupling protein 1 (UCP1) content, and the hypothesis that UCP1 deletion would abolish sex differences in insulin sensitivity and that whitening of thoracic periaortic BAT caused by U CP1 loss would be accompanied with impairedThoracic aortic function was tested.
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Brown adipose tissue in obesity: Fractalkine-receptor dependent immune cell recruitment affects metabolic-related gene expression.
TL;DR: The results highlight the importance of fractalkine-CX3CR1 interaction in recruitment of macrophages into the BAT of obese mice which might contribute to local tissue inflammation, adipose tissue remodeling and regulation of metabolic-related genes.
Journal ArticleDOI
The attenuating effects of pyridoxamine on adipocyte hypertrophy and inflammation differ by adipocyte location
Seyeon Oh,H.K. Ahn,Hyunjin Park,Jae-Ik Lee,Kook Yang Park,Daehee Hwang,Sojung Lee,Kuk Hui Son,Kyunghee Byun +8 more
TL;DR: Pyridoxamine was found to suppress weight increases and M1 polarization, and to increase Glo-1 expression through the RAGE pathway in perivascular and visceral fat tissues of HFD-induced obese rats, which suggest pyridOxamine is a candidate for the treatment of obesity or complications related to obesity-induced inflammation.
References
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TL;DR: The 2-Delta Delta C(T) method as mentioned in this paper was proposed to analyze the relative changes in gene expression from real-time quantitative PCR experiments, and it has been shown to be useful in the analysis of realtime, quantitative PCR data.
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Bioconductor: open software development for computational biology and bioinformatics
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A comparison of normalization methods for high density oligonucleotide array data based on variance and bias
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Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance.
Haiyan Xu,Glenn Barnes,Qing Yang,Guo Tan,Daseng Yang,Chieh J. Chou,Jason Sole,Andrew Nichols,Jeffrey S. Ross,Louis A. Tartaglia,Hong Chen +10 more
TL;DR: It is proposed that obesity-related insulin resistance is, at least in part, a chronic inflammatory disease initiated in adipose tissue, and that macrophage-related inflammatory activities may contribute to the pathogenesis of obesity-induced insulin resistance.