Similarity of mouse perivascular and brown adipose tissues and their resistance to diet-induced inflammation
Timothy P. Fitzgibbons,Sophia Kogan,Myriam Aouadi,Gregory M. Hendricks,Juerg R. Straubhaar,Michael P. Czech +5 more
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TLDR
In this article, perivascular adipose tissue (PVAT) is a unique adipose depot that likely influences vascular function and susceptibility to pathogenesis in obesity and metabolic syndrome.Abstract:
Thoracic perivascular adipose tissue (PVAT) is a unique adipose depot that likely influences vascular function and susceptibility to pathogenesis in obesity and the metabolic syndrome. Surprisingly...read more
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Regional differences in perivascular adipose tissue impacting vascular homeostasis
TL;DR: The adipose-vascular axis may represent a novel target for pharmacological intervention in vasculopathy in cardiometabolic disorders and heterogeneous PVAT as a specialized organ that can differentially regulate vascular function depending on its anatomical location is considered.
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Perivascular adipose tissue (PVAT) in atherosclerosis: a double-edged sword.
TL;DR: Since PVAT plays crucial roles in regulating key steps of Atherosclerosis development, it may constitute a novel therapeutic target for the prevention and treatment of atherosclerosis.
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‘Browning’ the cardiac and peri-vascular adipose tissues to modulate cardiovascular risk
TL;DR: The risks of excess cardiac and vascular adiposity and potential mechanisms by which restoring the brown phenotype i.e. “re-browning” could potentially be achieved in clinically relevant populations are discussed.
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Reassessing Human Adipose Tissue
TL;DR: The functional roles of human white and brown adipose tissue and its excess in obesity, as well as its far-reaching, complementary physiological roles in the endocrine system are discussed in this article .
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Time-course microarrays reveal early activation of the immune transcriptome and adipokine dysregulation leads to fibrosis in visceral adipose depots during diet-induced obesity
Eun-Young Kwon,Su-Kyung Shin,Yun-Young Cho,Un Ju Jung,Eunjung Kim,Taesun Park,Jung Han Yoon Park,Jong Won Yun,Robin A. McGregor,Yong Bok Park,Myung-Sook Choi +10 more
TL;DR: In diet-induced obesity, early activation of TLR-mediated inflammatory signalling cascades by CD antigen genes, leads to increased expression of pro-inflammatory cytokines and chemokines, resulting in chronic low-grade inflammation.
References
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Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance.
Haiyan Xu,Glenn Barnes,Qing Yang,Guo Tan,Daseng Yang,Chieh J. Chou,Jason Sole,Andrew Nichols,Jeffrey S. Ross,Louis A. Tartaglia,Hong Chen +10 more
TL;DR: It is proposed that obesity-related insulin resistance is, at least in part, a chronic inflammatory disease initiated in adipose tissue, and that macrophage-related inflammatory activities may contribute to the pathogenesis of obesity-induced insulin resistance.