Similarity of mouse perivascular and brown adipose tissues and their resistance to diet-induced inflammation
Timothy P. Fitzgibbons,Sophia Kogan,Myriam Aouadi,Gregory M. Hendricks,Juerg R. Straubhaar,Michael P. Czech +5 more
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In this article, perivascular adipose tissue (PVAT) is a unique adipose depot that likely influences vascular function and susceptibility to pathogenesis in obesity and metabolic syndrome.Abstract:
Thoracic perivascular adipose tissue (PVAT) is a unique adipose depot that likely influences vascular function and susceptibility to pathogenesis in obesity and the metabolic syndrome. Surprisingly...read more
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Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease.
Alan Chait,Laura J. den Hartigh +1 more
TL;DR: The mechanisms by which dysfunctional adipose tissue simultaneously promote T2DM and CVD, focusing on adipose tissues depot-specific adipokines, inflammatory profiles, and metabolism, will be the focus of this review.
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Control of brown and beige fat development
Wenshan Wang,Patrick Seale +1 more
TL;DR: F Fate-mapping analyses have identified progenitor populations that give rise to brown and beige fat cells, and have revealed unanticipated cell-lineage relationships between vascular smooth muscle cells and bege adipocytes, and between skeletal Muscle cells and brown fat.
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Obesity-Induced Changes in Adipose Tissue Microenvironment and Their Impact on Cardiovascular Disease
TL;DR: This review focuses on the microenvironment of adipose tissue and how it influences cardiovascular disorders, including atherosclerosis and ischemic heart diseases, through the systemic actions of adipokines.
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What causes the insulin resistance underlying obesity
TL;DR: The need to better understand the mechanisms linking visceral adiposity with liver fat accumulation, the mechanisms by which ectopic fat accumulation cause insulin resistance, and the size of adipose tissue depots is determined is underscored.
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The Vascular Endothelium of the Adipose Tissue Gives Rise to Both White and Brown Fat Cells
Khanh-Van Tran,Olga Gealekman,Andrea Frontini,Maria Cristina Zingaretti,Manrico Morroni,Antonio Giordano,Arianna Smorlesi,Jessica Perugini,Rita De Matteis,Andrea Sbarbati,Silvia Corvera,Saverio Cinti +11 more
TL;DR: It is found that murine endothelial cells of classic white and brown fat depots share ultrastructural characteristics with pericytes, which are pluripotent and can potentially give rise to preadipocytes, suggesting an endothelial origin of murine and human adipocytes.
References
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Eugenia Nikolsky,Edward J. Kosinski,Gregory J. Mishkel,Carey Kimmelstiel,Thomas F. McGarry,Roxana Mehran,Martin B. Leon,Mary E. Russell,Stephen G. Ellis,Gregg W. Stone +9 more
TL;DR: Obesity is an important risk factor for clinical and angiographic restenosis and for composite major adverse cardiac events in patients who receive bare-metal stents andPaclitaxel-eluting stents attenuate the increased risk associated with obesity, such that the intermediate-term prognosis after percutaneous coronary intervention is independent of weight.
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Estrogen Attenuates Integrin-β3–Dependent Adventitial Fibroblast Migration After Inhibition of Osteopontin Production in Vascular Smooth Muscle Cells
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