Journal ArticleDOI
"Slip, sliding away": phospholipase D and the Golgi apparatus.
TLDR
Recent observations on PLD localization to the Golgi apparatus are discussed and how members of this enzyme family might play a role in regulating the structure of this organelle.About:
This article is published in Trends in Cell Biology.The article was published on 2003-10-01. It has received 79 citations till now. The article focuses on the topics: Golgi apparatus & Phospholipase D.read more
Citations
More filters
Journal ArticleDOI
CD28 and CTLA-4 coreceptor expression and signal transduction.
TL;DR: The current knowledge of the CD28 and CTLA‐4 signaling mechanisms [involving phosphatidylinositol 3 kinase (PI3K), growth factor receptor‐bound protein 2 (Grb2), Filamin A, protein kinase C θ (PKCθ), and phosphatases] that control T‐cell immunity are outlined.
Journal ArticleDOI
Choline metabolism in malignant transformation
TL;DR: Abnormal choline metabolism is emerging as a metabolic hallmark that is associated with oncogenesis and tumour progression, and increased levels of these compounds provide a non-invasive biomarker of transformation, staging and response to therapy.
Journal ArticleDOI
Molecular regulation of mast cell activation
TL;DR: The unifying theme is that the regulatory steps mentioned herein are required for promoting effective responses while protecting against unwanted inflammatory responses.
Journal ArticleDOI
Membrane phospholipid synthesis and endoplasmic reticulum function
Paolo Fagone,Suzanne Jackowski +1 more
TL;DR: The generalized endoplasmic reticulum compartment is a central site for membrane lipid biogenesis, and examples of the emerging relationships between alterations in lipid composition, regulation of membrane lipid biosynthesis, and cellular secretory function are discussed.
Journal ArticleDOI
Cellular stress response pathways and ageing: intricate molecular relationships
TL;DR: The molecular mechanisms that link ageing to main stress response pathways are surveyed, and how each pathway contributes to modulate the ageing process is discussed.
References
More filters
Journal ArticleDOI
ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity
TL;DR: The current finding suggests that PLD activity plays a prominent role in the action of ARF and that ARF may be a key component in the generation of second messengers via phospholipase D.
Journal ArticleDOI
Phosphatidylinositol 4-Phosphate 5-Kinase α Is a Downstream Effector of the Small G Protein ARF6 in Membrane Ruffle Formation
Akira Honda,Masahiro Nogami,Takeaki Yokozeki,Masakazu Yamazaki,Hiroshi Nakamura,Hiroshi Watanabe,Kazumasa Kawamoto,Kazuhisa Nakayama,Andrew J. Morris,Michael A. Frohman,Yasunori Kanaho +10 more
TL;DR: PI(4)P5Kalpha is a downstream effector of ARF 6 and when ARF6 is activated by agonist stimulation, it triggers recruitment of a diverse but interactive set of signaling molecules into sites of active cytoskeletal and membrane rearrangement.
Journal ArticleDOI
Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization
William C. Colley,Tsung-Chang Sung,Richard Roll,John Jenco,Scott M. Hammond,Yelena M. Altshuller,Dafna Bar-Sagi,Andrew J. Morris,Michael A. Frohman +8 more
TL;DR: PLD2 is a newly identified mammalian PLD isoform with novel regulatory properties that provokes cortical reorganization and undergoes redistribution in serum-stimulated cells, suggesting that it may have a role in signal-induced cytoskeletal regulation and/or endocytosis.
Journal ArticleDOI
Human ADP-ribosylation Factor-activated Phosphatidylcholine-specific Phospholipase D Defines a New and Highly Conserved Gene Family
Scott M. Hammond,Yelena M. Altshuller,Tsung Chang Sung,Simon A. Rudge,Kristine Rose,JoAnne Engebrecht,Andrew J. Morris,Michael A. Frohman +7 more
TL;DR: The identification of the first human PLD cDNA is reported, which defines a new and highly conserved gene family and likely encodes the gene product responsible for the most widely studied endogenous PLD activity.
Journal ArticleDOI
Phospholipase D: a downstream effector of ARF in granulocytes
Shamshad Cockcroft,Geraint M.H. Thomas,Amanda Fensome,Blandine Geny,Emer Cunningham,Ivan Gout,Ian Hiles,Nicholas F. Totty,Oanh Truong,J. Justin Hsuan +9 more
TL;DR: Results indicate that phospholipase D is a downstream effector of ARF1 and ARF3, which would suggest that alterations in lipid content by PLD are an important determinant in vesicular dynamics.