Journal ArticleDOI
Structural brain magnetic resonance imaging of limbic and thalamic volumes in pediatric bipolar disorder
Jean A. Frazier,Sufen Chiu,Janis L. Breeze,Nikos Makris,Nicholas Lange,David N. Kennedy,Martha R. Herbert,Eileen K. Bent,Vamsi K. Koneru,Megan E. Dieterich,Steven M. Hodge,Scott L. Rauch,P. Ellen Grant,Bruce M. Cohen,Larry J. Seidman,Verne S. Caviness,Joseph Biederman +16 more
TLDR
Findings support the hypothesis that the limbic system, in particular the hippocampus, may be involved in the pathophysiology of pediatric bipolar disorder.Abstract:
Background: Youths with bipolar disorder are ideal for studying illness pathophysiology given their early presentation, lack of extended treatment, and high genetic loading. Adult bipolar disorder MRI studies have focused increasingly on limbic structures and the thalamus because of their role in mood and cognition. On the basis of adult studies, the authors hypothesized a priori that youths with bipolar disorder would have amygdalar, hippocampal, and thalamic volume abnormalities. METHOD: Forty-three youths 6–16 years of age with DSM-IV bipolar disorder (23 male, 20 female) and 20 healthy comparison subjects (12 male, eight female) similar in age and sex underwent structured and clinical interviews, neurological examination, and cognitive testing. Differences in limbic and thalamic brain volumes, on the logarithmic scale, were tested using a two-way (diagnosis and sex) univariate analysis of variance, with total cerebral volume and age controlled. RESULTS: The subjects with bipolar disorder had smaller h...read more
Citations
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Journal ArticleDOI
A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder.
TL;DR: A neural model of emotion regulation that includes neural systems implicated in different voluntary and automatic emotion regulatory subprocesses is developed and used as a theoretical framework to examine functional neural abnormalities in these neural systems that may predispose to the development of a major psychiatric disorder, bipolar disorder.
Journal ArticleDOI
Meta-analysis, database, and meta-regression of 98 structural imaging studies in bipolar disorder.
TL;DR: The meta-analyses revealed robust but regionally nonspecific changes of brain structure in bipolar disorder and revealed individual studies will remain underpowered unless sample size is increased or improvements in phenotypic selection and imaging methods are made to reduce within-study heterogeneity.
Journal ArticleDOI
Lead-DBS v2: Towards a comprehensive pipeline for deep brain stimulation imaging.
Andreas Horn,Ningfei Li,Till A. Dembek,Ari D Kappel,Chadwick B. Boulay,Siobhan Ewert,Anna Tietze,Andreas Husch,Thushara Perera,Wolf-Julian Neumann,Marco Reisert,Hang Si,Robert Oostenveld,Chris Rorden,Fang-Cheng Yeh,Qianqian Fang,Todd M. Herrington,Johannes Vorwerk,Andrea A. Kühn +18 more
TL;DR: This work represents a multi‐institutional collaborative effort to develop a comprehensive, open source pipeline for DBS imaging and connectomics, which has already empowered several studies, and may facilitate a variety of future studies in the field.
Journal ArticleDOI
Bipolar and Major Depressive Disorder: Neuroimaging the Developmental-Degenerative Divide
Jonathan Savitz,Wayne C. Drevets +1 more
TL;DR: It is suggested that environmental stress and genetic risk variants interact with each other in a complex manner to alter neural circuitry and precipitate illness.
Journal ArticleDOI
Allostatic load in bipolar disorder: implications for pathophysiology and treatment.
Flávio Kapczinski,Eduard Vieta,Eduard Vieta,Ana Cristina Andreazza,Benicio N. Frey,Fabiano Alves Gomes,Juliana Tramontina,Márcia Kauer-Sant'Anna,Rodrigo Grassi-Oliveira,Robert M. Post +9 more
TL;DR: Al provides an explanatory link to apparently unrelated findings such as cognitive impairment and higher rates of physical comorbidity and mortality that are observed in the course of BD and further highlight the importance of effective long-term prophylaxis.
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