Journal ArticleDOI
Structure and function of the blood–brain barrier
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TLDR
The structure and function of the BBB is summarised, the physical barrier formed by the endothelial tight junctions, and the transport barrier resulting from membrane transporters and vesicular mechanisms are described.About:
This article is published in Neurobiology of Disease.The article was published on 2010-01-01. It has received 3783 citations till now. The article focuses on the topics: Blood–brain barrier.read more
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Inhibition of VEGF and Angiopoietin-2 to Reduce Brain Metastases of Breast Cancer Burden.
Kaci A. Bohn,Kaci A. Bohn,Chris E. Adkins,Chris E. Adkins,Chris E. Adkins,Mohamed Ismail Nounou,Paul R. Lockman +6 more
TL;DR: Combinatorial inhibition of VEGF and angiopoietin reduces lesion permeability and brain metastatic burden in mouse model of brain metastases of breast cancer.
Journal ArticleDOI
Developmental expression of multidrug resistance phosphoglycoprotein (P-gp) in the mouse fetal brain and glucocorticoid regulation.
TL;DR: P-gp mediated protection of the fetal brain increases with advancing gestation in an isoform-specific manner and this will likely have clinical implication given the extensive use of synthetic glucocorticoid in the management of PTL.
Journal ArticleDOI
Nanotechnology-based drug delivery for central nervous system disorders.
Thuy Trang Nguyen,Thi Thuy Dung Nguyen,Tuong Kha Vo,Nguyen-Minh-An Tran,Minh Kim Nguyen,Toi Van Vo,Giau Van Vo +6 more
TL;DR: In this paper, a review aimed to highlight advances in research on the development of nano-based therapeutics for their implications in therapy of CNS disorders, and the challenges during clinical translation of nanomedicine from bench to bed side is also discussed.
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ApoE-Targeting Increases the Transfer of Solid Lipid Nanoparticles with Donepezil Cargo across a Culture Model of the Blood–Brain Barrier
Gizem Rüya Topal,Mária Mészáros,Gergő Porkoláb,Anikó Szecskó,Tamás Ferenc Polgár,László Siklós,Mária A. Deli,Szilvia Veszelka,Asuman Bozkir +8 more
TL;DR: In this article, the authors designed a nanoscale drug delivery system for a more efficient transfer of donepezil, an anticholinergic drug in the therapy of Alzheimer's disease across the blood-brain barrier (BBB).
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Brain tight junction protein expression in sepsis in an autopsy series.
Kristo Erikson,Hannu Tuominen,Merja Vakkala,Janne Liisanantti,Tuomo J. Karttunen,Hannu Syrjälä,Tero Ala-Kokko +6 more
TL;DR: In fatal sepsis, damaged BBB defined as a loss of cerebral endothelial expression of occludin is related with severe organ dysfunction and systemic inflammation.
References
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Journal ArticleDOI
Principles of Neural Science
TL;DR: The editors have done a masterful job of weaving together the biologic, the behavioral, and the clinical sciences into a single tapestry in which everyone from the molecular biologist to the practicing psychiatrist can find and appreciate his or her own research.
Journal ArticleDOI
Astrocyte–endothelial interactions at the blood–brain barrier
TL;DR: Specific interactions between the brain endothelium, astrocytes and neurons that may regulate blood–brain barrier function are explored to lead to the development of new protective and restorative therapies.
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The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
TL;DR: These findings support developments of new therapeutic approaches for chronic neurodegenerative disorders directed at the blood-brain barrier and other nonneuronal cells of the neurovascular unit.
Journal ArticleDOI
Junctions between intimately apposed cell membranes in the vertebrate brain
TL;DR: Endothelial and epithelial tight junctions occlude the interspaces between blood and parenchyma or cerebral ventricles, thereby constituting a structural basis for the blood-brain and blood-cerebrospinal fluid barriers.
Journal ArticleDOI
The human ATP-binding cassette (ABC) transporter superfamily
TL;DR: The ATP-binding cassette (ABC) transporters are essential for many processes in the cell and mutations in these genes cause or contribute to several human genetic disorders including cystic fibrosis, neurological disease, retinal degeneration, cholesterol and bile transport defects, anemia, and drug response.
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