Journal ArticleDOI
Structure and function of the blood–brain barrier
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TLDR
The structure and function of the BBB is summarised, the physical barrier formed by the endothelial tight junctions, and the transport barrier resulting from membrane transporters and vesicular mechanisms are described.About:
This article is published in Neurobiology of Disease.The article was published on 2010-01-01. It has received 3783 citations till now. The article focuses on the topics: Blood–brain barrier.read more
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LDL-lipids from patients with hypercholesterolaemia and Alzheimer's disease are inflammatory to microvascular endothelial cells: mitigation by statin intervention.
Irundika H.K. Dias,Caroline L. R. Brown,Maria Cristina Polidori-Nelles,Gregory Y.H. Lip,Helen R. Griffiths +4 more
TL;DR: LD-L from hypercholesterolaemic, AD and AD-plus patients are inflammatory to HMVECs, and in vivo intervention with statins reduces the damaging effects of LDL-L on HMV ECs.
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Seizure progression and inflammatory mediators promote pericytosis and pericyte-microglia clustering at the cerebrovasculature.
Wendy Klement,Rita Garbelli,Emma Zub,Laura Rossini,Laura Tassi,Benoit Girard,Marine Blaquière,Federica Bertaso,Julie Perroy,Frédéric de Bock,Nicola Marchi +10 more
TL;DR: Results indicate the occurrence of pericytosis during seizures and introduce a pericyte-microglial mediated mechanism of blood-brain barrier dysfunction in epilepsy.
Journal ArticleDOI
Dual-Sensitive Nanomicelles Enhancing Systemic Delivery of Therapeutically Active Antibodies Specifically into the Brain
Jinbing Xie,Daniel Gonzalez-Carter,Theofilus A. Tockary,Nakamura Noriko,Yonger Xue,Makoto Nakakido,Hiroki Akiba,Anjaneyulu Dirisala,Xueying Liu,Kazuko Toh,Tao Yang,Zengtao Wang,Shigeto Fukushima,Junjie Li,Sabina Quader,Kouhei Tsumoto,Takanori Yokota,Yasutaka Anraku,Kazunori Kataoka +18 more
TL;DR: Toxic benefits were obtained by successfully inhibiting Aβ1-42 aggregation in Alzheimer's disease mice systemically treated with 3D6-Fab-loaded glucosylated PM and this nanocarrier system represents a promising method for effectively delivering functional antibody agents into the brain and treating neurological diseases.
Journal ArticleDOI
A Critical Review of the Use of Surfactant-Coated Nanoparticles in Nanomedicine and Food Nanotechnology
TL;DR: A review of the use of surfactant-coated nanoparticles in nanomedicine and food nanotechnology can be found in this article, where the authors systematically describe these nanoparticles through various sections in order.
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Blood-Brain Barrier- and Blood-Brain Tumor Barrier-Penetrating Peptide-Derived Targeted Therapeutics for Glioma and Malignant Tumor Brain Metastases.
TL;DR: A novel BBB/BBTB-penetrating peptide was identified from phage-displayed peptide library and can serve as a universal vector for shuttling compounds across the BBB; therefore, it may have wide applications for treating brain tumors as well as other CNS diseases.
References
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Principles of Neural Science
TL;DR: The editors have done a masterful job of weaving together the biologic, the behavioral, and the clinical sciences into a single tapestry in which everyone from the molecular biologist to the practicing psychiatrist can find and appreciate his or her own research.
Journal ArticleDOI
Astrocyte–endothelial interactions at the blood–brain barrier
TL;DR: Specific interactions between the brain endothelium, astrocytes and neurons that may regulate blood–brain barrier function are explored to lead to the development of new protective and restorative therapies.
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The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
TL;DR: These findings support developments of new therapeutic approaches for chronic neurodegenerative disorders directed at the blood-brain barrier and other nonneuronal cells of the neurovascular unit.
Journal ArticleDOI
Junctions between intimately apposed cell membranes in the vertebrate brain
TL;DR: Endothelial and epithelial tight junctions occlude the interspaces between blood and parenchyma or cerebral ventricles, thereby constituting a structural basis for the blood-brain and blood-cerebrospinal fluid barriers.
Journal ArticleDOI
The human ATP-binding cassette (ABC) transporter superfamily
TL;DR: The ATP-binding cassette (ABC) transporters are essential for many processes in the cell and mutations in these genes cause or contribute to several human genetic disorders including cystic fibrosis, neurological disease, retinal degeneration, cholesterol and bile transport defects, anemia, and drug response.
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