Journal ArticleDOI
Structure and function of the blood–brain barrier
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TLDR
The structure and function of the BBB is summarised, the physical barrier formed by the endothelial tight junctions, and the transport barrier resulting from membrane transporters and vesicular mechanisms are described.About:
This article is published in Neurobiology of Disease.The article was published on 2010-01-01. It has received 3783 citations till now. The article focuses on the topics: Blood–brain barrier.read more
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Principles of Neural Science
TL;DR: The editors have done a masterful job of weaving together the biologic, the behavioral, and the clinical sciences into a single tapestry in which everyone from the molecular biologist to the practicing psychiatrist can find and appreciate his or her own research.
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Physiology of Microglia
TL;DR: Current studies indicate that even in the normal brain, microglia have highly motile processes by which they scan their territorial domains, and microglial cells are considered the most susceptible sensors of brain pathology.
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Vascular Contributions to Cognitive Impairment and Dementia A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association
Philip B. Gorelick,Angelo Scuteri,Sandra E. Black,Charles DeCarli,Steven M. Greenberg,Costantino Iadecola,Lenore J. Launer,Stéphane Laurent,Oscar L. Lopez,David L. Nyenhuis,Ronald C. Petersen,Julie A. Schneider,Christophe Tzourio,Donna K. Arnett,David A. Bennett,Helena C. Chui,Randall T. Higashida,Ruth Lindquist,Peter M. Nilsson,Gustavo C. Román,Frank W. Sellke,Sudha Seshadri +21 more
TL;DR: This scientific statement provides an overview of the evidence on vascular contributions to cognitive impairment and dementia and provides evidence that subcortical forms of VCI with white matter hyperintensities and small deep infarcts are common and risk markers for VCI are the same as traditional risk factors for stroke.
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Pericytes: developmental, physiological, and pathological perspectives, problems, and promises.
TL;DR: The history of investigations into pericytes, the mural cells of blood microvessels, are reviewed, emerging concepts are indicated, and problems and promise are pointed out.
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Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders
TL;DR: This Review discusses neuroimaging studies in the living human brain and post-mortem tissue as well as biomarker studies demonstrating BBB breakdown in Alzheimer disease, Parkinson disease, Huntington disease, amyotrophic lateral sclerosis, multiple sclerosis, HIV-1-associated dementia and chronic traumatic encephalopathy.
References
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Journal ArticleDOI
Multidrug Resistance-Associated Proteins: Expression and Function in the Central Nervous System
TL;DR: It is proposed that these primary and secondary barriers work in tandem to limit overall accumulation and distribution of xenobiotics in the central nervous system.
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ABCC Drug Efflux Pumps and Organic Anion Uptake Transporters in Human Gliomas and the Blood-Tumor Barrier
Holger Bronger,Jörg König,Kathrin Kopplow,Hans-Herbert Steiner,Rezvan Ahmadi,Christel Herold-Mende,Dietrich Keppler,Anne T. Nies +7 more
TL;DR: Analysis of the expression and localization of six members of the multidrug resistance protein family of ATP-dependent efflux pumps and of organic anion uptake transporters in 61 human glioma specimens indicates that expression of ABCC4 and ABCC5 is associated with an astrocytic phenotype, in accordance with their expression inAstrocytes and with the higher chemoresistance of astroCytic tumors as compared with oligodendrogliomas.
Journal ArticleDOI
Blood-brain barrier breakdown in septic encephalopathy and brain tumours.
TL;DR: The results suggest that the pathophysiology of brain oedema is multifactorial, but that there may be common processes operating regardless of the aetiology.
Journal ArticleDOI
Receptor for advanced glycation endproducts: a multiligand receptor magnifying cell stress in diverse pathologic settings
TL;DR: Observations suggest that RAGE might represent a therapeutic target in a diverse group of seemingly unrelated disorders linked only by a multiligand receptor with an unusually wide and diverse repertoire of ligands, namely, RAGE.
Journal ArticleDOI
Assembly and sealing of tight junctions: possible participation of G-proteins, phospholipase C, protein kinase C and calmodulin.
Maria S. Balda,Lorenza González-Mariscal,Rubén G. Contreras,Marina Macías-Silva,M. E. Torres-Marquez,J. A. García Sáinz,Marcelino Cereijido +6 more
TL;DR: The results indicate that junction formation may be controlled by a network of reactions where G-proteins, phospholipase C, adenylate cyclase, protein kinase C and CaM are involved.
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