Journal ArticleDOI
Structure and function of the blood–brain barrier
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TLDR
The structure and function of the BBB is summarised, the physical barrier formed by the endothelial tight junctions, and the transport barrier resulting from membrane transporters and vesicular mechanisms are described.About:
This article is published in Neurobiology of Disease.The article was published on 2010-01-01. It has received 3783 citations till now. The article focuses on the topics: Blood–brain barrier.read more
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Norrin Protected Blood–Brain Barrier Via Frizzled-4/β-Catenin Pathway After Subarachnoid Hemorrhage in Rats
Yujie Chen,Yang Zhang,Junjia Tang,Fei Liu,Qin Hu,Chunxia Luo,Jiping Tang,Hua Feng,John H. Zhang +8 more
TL;DR: Norrin protected blood–brain barrier integrity and improved neurological outcome after SAH, and the action of Norrin appeared mediated by Frizzled-4 receptor activation, which promoted &bgr;-catenin nuclear translocation, which then enhanced Occludin, VE-Cadherin, and ZO-1 expression.
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Barrier mechanisms in the Drosophila blood-brain barrier.
TL;DR: Findings strengthen the notion that many BBB mechanisms are conserved between vertebrates and invertebrates, and suggest that novel findings in invertebrate model organisms will have a significant impact on the understanding of vertebrate BBB functions.
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Effects of Resveratrol and other Polyphenols on Sirt1: Relevance to Brain Function During Aging
TL;DR: The positive effects of polyphenols on the prevention of the changes that occur during aging in the brain and their consequences on cognition are described, emphasizing the possible modulation of inflammaging bypolyphenols through a SIRT1-mediated mechanism.
Journal ArticleDOI
The inhibitory effect of mesenchymal stem cell on blood-brain barrier disruption following intracerebral hemorrhage in rats: contribution of TSG-6.
Min Chen,Xifeng Li,Xin Zhang,Xuying He,Lingfeng Lai,Yanchao Liu,Guohui Zhu,Wei Li,Hui Li,Qinrui Fang,Zequn Wang,Chuanzhi Duan +11 more
TL;DR: It is demonstrated that intravenous transplantation of MSCs decreased the levels of ONOO− and degree of BBB leakage and improved neurological recovery in a rat ICH model, which may provide a new insight for future therapies that aim to prevent breakdown of the BBB in patients with ICH.
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Liposomes for brain delivery.
TL;DR: This review explores the different approaches studied to transport and deliver therapeutics and imaging agents to the brain by using liposomes and particular attention is paid to the anatomy of the BBB and different physiological transport mechanisms available for drug permeation.
References
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Principles of Neural Science
TL;DR: The editors have done a masterful job of weaving together the biologic, the behavioral, and the clinical sciences into a single tapestry in which everyone from the molecular biologist to the practicing psychiatrist can find and appreciate his or her own research.
Journal ArticleDOI
Astrocyte–endothelial interactions at the blood–brain barrier
TL;DR: Specific interactions between the brain endothelium, astrocytes and neurons that may regulate blood–brain barrier function are explored to lead to the development of new protective and restorative therapies.
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The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
TL;DR: These findings support developments of new therapeutic approaches for chronic neurodegenerative disorders directed at the blood-brain barrier and other nonneuronal cells of the neurovascular unit.
Journal ArticleDOI
Junctions between intimately apposed cell membranes in the vertebrate brain
TL;DR: Endothelial and epithelial tight junctions occlude the interspaces between blood and parenchyma or cerebral ventricles, thereby constituting a structural basis for the blood-brain and blood-cerebrospinal fluid barriers.
Journal ArticleDOI
The human ATP-binding cassette (ABC) transporter superfamily
TL;DR: The ATP-binding cassette (ABC) transporters are essential for many processes in the cell and mutations in these genes cause or contribute to several human genetic disorders including cystic fibrosis, neurological disease, retinal degeneration, cholesterol and bile transport defects, anemia, and drug response.
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