Journal ArticleDOI
Structure and function of the blood–brain barrier
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TLDR
The structure and function of the BBB is summarised, the physical barrier formed by the endothelial tight junctions, and the transport barrier resulting from membrane transporters and vesicular mechanisms are described.About:
This article is published in Neurobiology of Disease.The article was published on 2010-01-01. It has received 3783 citations till now. The article focuses on the topics: Blood–brain barrier.read more
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Polar invasion and translocation of Neisseria meningitidis and Streptococcus suis in a novel human model of the blood-cerebrospinal fluid barrier.
Christian Schwerk,Thalia Papandreou,D. Schuhmann,Laura Nickol,Julia Borkowski,Ulrike Steinmann,Natascha Quednau,Carolin Stump,Christel Weiss,Jürgen Berger,Hartwig Wolburg,Heike Claus,Ulrich Vogel,Hiroshi Ishikawa,Tobias Tenenbaum,Horst Schroten +15 more
TL;DR: A functional human BCSFB model based on human choroid plexus papilloma cells (HIBCPP) is described for the first time, which display typical hallmarks of a B CSFB as the expression of junctional proteins and formation of tight junctions, a high electrical resistance and minimal levels of macromolecular flux when grown on transwell filters.
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In vitro modeling of the neurovascular unit: advances in the field
Aditya Bhalerao,Farzane Sivandzade,Sabrina Rahman Archie,Ekram Ahmed Chowdhury,Behnam Noorani,Luca Cucullo +5 more
TL;DR: The advances and progress in the design and application of functional in vitro BBB platforms with a focus on rapidly advancing technologies are summarized.
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Traumatic brain injury, neuroinflammation, and post-traumatic headaches.
TL;DR: This review considers selected aspects of the inflammatory response following traumatic brain injury, with an emphasis on the role of glial cells as mediators of maladaptive post‐traumatic inflammation.
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Novel Central Nervous System Drug Delivery Systems
TL;DR: Several novel drug delivery techniques, including intranasal drug delivery, nanoparticles, drug modifications, convection‐enhanced infusion, and ultrasound‐mediated drug delivery are outlined, giving potential for more effective and safer therapies in the future.
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MiR-21 alleviates secondary blood-brain barrier damage after traumatic brain injury in rats.
Xintong Ge,Zhaoli Han,Fanglian Chen,Haichen Wang,Baoliang Zhang,Rongcai Jiang,Ping Lei,Jianning Zhang +7 more
TL;DR: It is found that miR-21 exerts the protective effect on BBB by activating the Ang-1/Tie-2 axis in BMVECs and could be a potential therapeutic target for interventions of secondary BBB damage after TBI.
References
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Principles of Neural Science
TL;DR: The editors have done a masterful job of weaving together the biologic, the behavioral, and the clinical sciences into a single tapestry in which everyone from the molecular biologist to the practicing psychiatrist can find and appreciate his or her own research.
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Astrocyte–endothelial interactions at the blood–brain barrier
TL;DR: Specific interactions between the brain endothelium, astrocytes and neurons that may regulate blood–brain barrier function are explored to lead to the development of new protective and restorative therapies.
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The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
TL;DR: These findings support developments of new therapeutic approaches for chronic neurodegenerative disorders directed at the blood-brain barrier and other nonneuronal cells of the neurovascular unit.
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Junctions between intimately apposed cell membranes in the vertebrate brain
TL;DR: Endothelial and epithelial tight junctions occlude the interspaces between blood and parenchyma or cerebral ventricles, thereby constituting a structural basis for the blood-brain and blood-cerebrospinal fluid barriers.
Journal ArticleDOI
The human ATP-binding cassette (ABC) transporter superfamily
TL;DR: The ATP-binding cassette (ABC) transporters are essential for many processes in the cell and mutations in these genes cause or contribute to several human genetic disorders including cystic fibrosis, neurological disease, retinal degeneration, cholesterol and bile transport defects, anemia, and drug response.
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