Journal ArticleDOI
Structure and function of the blood–brain barrier
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TLDR
The structure and function of the BBB is summarised, the physical barrier formed by the endothelial tight junctions, and the transport barrier resulting from membrane transporters and vesicular mechanisms are described.About:
This article is published in Neurobiology of Disease.The article was published on 2010-01-01. It has received 3783 citations till now. The article focuses on the topics: Blood–brain barrier.read more
Citations
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Pathophysiology of cerebral oedema in acute liver failure.
TL;DR: There is no fully efficacious therapy for cerebral oedema other than liver transplantation and this reflects incomplete knowledge of the precise mechanisms underlying this process which remain largely unknown.
Journal ArticleDOI
A Triple Culture Model of the Blood-Brain Barrier Using Porcine Brain Endothelial cells, Astrocytes and Pericytes.
TL;DR: This syngenic porcine in vitro BBB model is comparable to triple cultures using PBECs, rat astrocytes and rat pericytes with respect to TEER formation, low passive permeability, and expression of hallmark proteins signifying the brain endothelium.
Journal ArticleDOI
Targeted Nanotechnology in Glioblastoma Multiforme.
TL;DR: A better understanding of CSC properties could result in the development of precise nanotherapies to fulfill unmet clinical needs, and novel biological strategies focused on manipulating gene expression for cancer therapy are analyzed.
Journal ArticleDOI
Estrogen protects the blood-brain barrier from inflammation-induced disruption and increased lymphocyte trafficking.
Elisa Maggioli,Simon McArthur,Claudio Mauro,Julius Kieswich,D.H.M. Kusters,Chris P. M. Reutelingsperger,Muhammad M. Yaqoob,Egle Solito +7 more
TL;DR: Investigation of the effects of estradiol upon key barrier features, namely paracellular permeability, transendothelial electrical resistance, tight junction integrity and lymphocyte transmigration under basal and inflammatory conditions, modeled by treatment with TNFα and IFNγ enhances understanding of the beneficial role it plays in neurovascular/neuroimmune disease.
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Choroid plexus and the blood-cerebrospinal fluid barrier in disease.
TL;DR: The current state of knowledge with regard to the roles of the CP and B-CSF barrier in the pathophysiology of various types of CNS diseases is described and summarized and sets up the foundation for further avenues of research.
References
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Principles of Neural Science
TL;DR: The editors have done a masterful job of weaving together the biologic, the behavioral, and the clinical sciences into a single tapestry in which everyone from the molecular biologist to the practicing psychiatrist can find and appreciate his or her own research.
Journal ArticleDOI
Astrocyte–endothelial interactions at the blood–brain barrier
TL;DR: Specific interactions between the brain endothelium, astrocytes and neurons that may regulate blood–brain barrier function are explored to lead to the development of new protective and restorative therapies.
Journal ArticleDOI
The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
TL;DR: These findings support developments of new therapeutic approaches for chronic neurodegenerative disorders directed at the blood-brain barrier and other nonneuronal cells of the neurovascular unit.
Journal ArticleDOI
Junctions between intimately apposed cell membranes in the vertebrate brain
TL;DR: Endothelial and epithelial tight junctions occlude the interspaces between blood and parenchyma or cerebral ventricles, thereby constituting a structural basis for the blood-brain and blood-cerebrospinal fluid barriers.
Journal ArticleDOI
The human ATP-binding cassette (ABC) transporter superfamily
TL;DR: The ATP-binding cassette (ABC) transporters are essential for many processes in the cell and mutations in these genes cause or contribute to several human genetic disorders including cystic fibrosis, neurological disease, retinal degeneration, cholesterol and bile transport defects, anemia, and drug response.
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