Journal ArticleDOI
Structure and function of the blood–brain barrier
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TLDR
The structure and function of the BBB is summarised, the physical barrier formed by the endothelial tight junctions, and the transport barrier resulting from membrane transporters and vesicular mechanisms are described.About:
This article is published in Neurobiology of Disease.The article was published on 2010-01-01. It has received 3783 citations till now. The article focuses on the topics: Blood–brain barrier.read more
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Novel Curcumin loaded nanoparticles engineered for Blood-Brain Barrier crossing and able to disrupt Abeta aggregates
Ruozi Barbara,Daniela Belletti,Francesca Pederzoli,Martina Masoni,Johannes Keller,Antonio Ballestrazzi,Maria Angela Vandelli,Giovanni Tosi,Andreas M. Grabrucker +8 more
TL;DR: C encapsulated Curcumin as active ingredient in PLGA (polylactide-co-glycolic-acid) nanoparticles (NPs), modified with g7 ligand for BBB crossing, showing no apparent toxicity of the formulated NPs, but a significant decrease of Aβ aggregates in response to CurCumin loaded NPs.
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Benchmarking in vitro tissue-engineered blood-brain barrier models.
Jackson G. DeStefano,John J. Jamieson,Raleigh M. Linville,Raleigh M. Linville,Peter C. Searson +4 more
TL;DR: A set of parameters associated with structure, infrastructure, microenvironment, barrier function, and cell function are described that are considered a starting point for benchmarking and validation of the blood–brain barrier in humans and animal models.
Journal ArticleDOI
Liposome delivery systems for the treatment of Alzheimer's disease.
TL;DR: Recent liposomal approaches to AD therapy, including mechanisms involved in facilitating their passage across the blood-brain barrier (BBB) and the evaluation of new therapeutic agents for blocking Aβ and/or tau aggregation are focused on.
Journal ArticleDOI
Regulation of ABC transporters at the blood–brain barrier
TL;DR: Recent progress in understanding the regulation of the expression and transport activity of ATP binding cassette transporters is reviewed and how this new information might aid in improving drug delivery to the brain is commented on.
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Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice.
Yasuhiko Yamamoto,Mingkun Liang,Seiichi Munesue,Kisaburo Deguchi,Ai Harashima,Kazumi Furuhara,Teruko Yuhi,Jing Zhong,Shirin Akther,Hisanori Goto,Yuya Eguchi,Yasuko Kitao,Osamu Hori,Yoshitake Shiraishi,Noriyuki Ozaki,Yu Shimizu,Tomoya Kamide,Akifumi Yoshikawa,Yasuhiko Hayashi,Mitsutoshi Nakada,Olga Lopatina,Maria Gerasimenko,Yulia K. Komleva,Natalia A. Malinovskaya,Alla B. Salmina,Masahide Asano,Katsuhiko Nishimori,Steven E. Shoelson,Hiroshi Yamamoto,Hiroshi Yamamoto,Haruhiro Higashida +30 more
TL;DR: The findings show that RAGE-mediated transport is critical to the behavioural actions of oxcytocin associated with parenting and social bonding, and it is shown that oxytocin is transported into the brain by the receptor for advanced glycation end-products (RAGE) on the blood-brain barrier.
References
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Principles of Neural Science
TL;DR: The editors have done a masterful job of weaving together the biologic, the behavioral, and the clinical sciences into a single tapestry in which everyone from the molecular biologist to the practicing psychiatrist can find and appreciate his or her own research.
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Astrocyte–endothelial interactions at the blood–brain barrier
TL;DR: Specific interactions between the brain endothelium, astrocytes and neurons that may regulate blood–brain barrier function are explored to lead to the development of new protective and restorative therapies.
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The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
TL;DR: These findings support developments of new therapeutic approaches for chronic neurodegenerative disorders directed at the blood-brain barrier and other nonneuronal cells of the neurovascular unit.
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Junctions between intimately apposed cell membranes in the vertebrate brain
TL;DR: Endothelial and epithelial tight junctions occlude the interspaces between blood and parenchyma or cerebral ventricles, thereby constituting a structural basis for the blood-brain and blood-cerebrospinal fluid barriers.
Journal ArticleDOI
The human ATP-binding cassette (ABC) transporter superfamily
TL;DR: The ATP-binding cassette (ABC) transporters are essential for many processes in the cell and mutations in these genes cause or contribute to several human genetic disorders including cystic fibrosis, neurological disease, retinal degeneration, cholesterol and bile transport defects, anemia, and drug response.
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