Journal ArticleDOI
Structure and function of the blood–brain barrier
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The structure and function of the BBB is summarised, the physical barrier formed by the endothelial tight junctions, and the transport barrier resulting from membrane transporters and vesicular mechanisms are described.About:
This article is published in Neurobiology of Disease.The article was published on 2010-01-01. It has received 3783 citations till now. The article focuses on the topics: Blood–brain barrier.read more
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Multiple blood-brain barrier transport mechanisms limit bumetanide accumulation, and therapeutic potential, in the mammalian brain.
Kerstin Römermann,Maren Fedrowitz,Philip Hampel,Edith Kaczmarek,Kathrin Töllner,Thomas Erker,Douglas H. Sweet,Wolfgang Löscher +7 more
TL;DR: It seems that both restricted passive diffusion and active efflux transport, mediated by Oat3 but also organic anion‐transporting polypeptide (Oatp) Oatp1a4 and multidrug resistance protein 4 explain the extremely low brain concentrations that are achieved after systemic administration of bumetanide, limiting the use of this drug for targeting abnormal expression of neuronal NKCC1 in brain diseases.
Journal ArticleDOI
Prenatal exposure to common environmental factors affects brain lipids and increases risk of developing autism spectrum disorders
TL;DR: How these exogenous agents are capable of crossing the protective barriers of the brain during critical developmental periods when barrier components are still being formed is described, underlines the importance of avoiding or limiting exposure to these factors during vulnerable periods in development.
Journal ArticleDOI
Using Evans Blue Dye to Determine Blood-Brain Barrier Integrity in Rodents
TL;DR: This protocol details the steps of EB extravasation in rodents and important aspects regarding critical steps and advantages are also provided.
Journal ArticleDOI
Molecular fabrications of smart nanobiomaterials and applications in personalized medicine.
TL;DR: The literature of nanoscale biomaterials described to be totally biocompatible, non-toxic,non-immunogenic, and biodegradable and furthermore, have been used or have the potential to be used in personalized biomedical applications such as drug delivery, tissue regeneration, and diagnostics are reviewed.
Journal ArticleDOI
The effects of obesity on the cerebral vasculature.
TL;DR: The effects of obesity on cerebral artery function and structure are discussed, including the endothelium and nitric oxide (NO) dependent dilation and the evidence that links these changes in vascular structure and function to cognitive decline and dementia.
References
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Principles of Neural Science
TL;DR: The editors have done a masterful job of weaving together the biologic, the behavioral, and the clinical sciences into a single tapestry in which everyone from the molecular biologist to the practicing psychiatrist can find and appreciate his or her own research.
Journal ArticleDOI
Astrocyte–endothelial interactions at the blood–brain barrier
TL;DR: Specific interactions between the brain endothelium, astrocytes and neurons that may regulate blood–brain barrier function are explored to lead to the development of new protective and restorative therapies.
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The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
TL;DR: These findings support developments of new therapeutic approaches for chronic neurodegenerative disorders directed at the blood-brain barrier and other nonneuronal cells of the neurovascular unit.
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Junctions between intimately apposed cell membranes in the vertebrate brain
TL;DR: Endothelial and epithelial tight junctions occlude the interspaces between blood and parenchyma or cerebral ventricles, thereby constituting a structural basis for the blood-brain and blood-cerebrospinal fluid barriers.
Journal ArticleDOI
The human ATP-binding cassette (ABC) transporter superfamily
TL;DR: The ATP-binding cassette (ABC) transporters are essential for many processes in the cell and mutations in these genes cause or contribute to several human genetic disorders including cystic fibrosis, neurological disease, retinal degeneration, cholesterol and bile transport defects, anemia, and drug response.
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Astrocyte–endothelial interactions at the blood–brain barrier
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