Journal ArticleDOI
Structure and function of the blood–brain barrier
Reads0
Chats0
TLDR
The structure and function of the BBB is summarised, the physical barrier formed by the endothelial tight junctions, and the transport barrier resulting from membrane transporters and vesicular mechanisms are described.About:
This article is published in Neurobiology of Disease.The article was published on 2010-01-01. It has received 3783 citations till now. The article focuses on the topics: Blood–brain barrier.read more
Citations
More filters
Journal ArticleDOI
Group B Streptococcus Engages an Inhibitory Siglec through Sialic Acid Mimicry to Blunt Innate Immune and Inflammatory Responses In Vivo
Yung-Chi Chang,Joshua Olson,Federico C. Beasley,Christine Tung,Jiquan Zhang,Paul R. Crocker,Ajit Varki,Victor Nizet +7 more
TL;DR: It is concluded that GBS Sia mimicry influences host innate immune and inflammatory responses in vivo through engagement of an inhibitory Siglec, with the ultimate outcome of the host response varying depending upon the site, stage and magnitude of infection.
Journal ArticleDOI
Wnt activation of immortalized brain endothelial cells as a tool for generating a standardized model of the blood brain barrier in vitro
Roberta Paolinelli,Monica Corada,Luca Ferrarini,Kavi Devraj,Cédric Artus,Cédric Artus,Cédric Artus,Cathrin J. Czupalla,Noemi Rudini,Luigi Maddaluno,Eleanna Papa,Britta Engelhardt,Pierre-Olivier Couraud,Pierre-Olivier Couraud,Pierre-Olivier Couraud,Stefan Liebner,Elisabetta Dejana +16 more
TL;DR: It is concluded that the brain-derived endothelial cell lines that are investigated gain their specialized characteristics upon activation of the canonical Wnt pathway, and this model may be thus suitable to test the BBB permeability to chemicals or large molecular weight proteins, transmigration of inflammatory cells, treatments with cytokines, and genetic manipulation.
Journal ArticleDOI
Nanoparticles and the blood-brain barrier: advancing from in-vitro models towards therapeutic significance.
David John Mc Carthy,Meenakshi Malhotra,Aoife M. O'Mahony,John F. Cryan,Caitriona M. O'Driscoll +4 more
TL;DR: This review provides a comprehensive description of the design and formulation of these nanoparticles including the rationale behind individual approaches and the ability of currently available in-vitro BBB models to accurately predict the in- vivo performance of targeted nanoparticles is critically assessed.
Journal ArticleDOI
Biomedical Nanoparticles: Overview of Their Surface Immune-Compatibility
TL;DR: The molecular interactions and responses of the immune system to the principal nanoparticle surface modifications used in nanomedicine are discussed.
Journal ArticleDOI
Drugs of abuse and blood-brain barrier endothelial dysfunction: A focus on the role of oxidative stress
TL;DR: The synergistic pathological impact of psychostimulants and HIV infection on BBB integrity with an emphasis on unifying role of endothelial oxidative stress is summarized and a mechanistic framework is provided to guide further investigations on specific molecular pathways to accelerate therapeutic approaches for the prevention of neurovascular deficits by drugs of abuse.
References
More filters
Journal ArticleDOI
Principles of Neural Science
TL;DR: The editors have done a masterful job of weaving together the biologic, the behavioral, and the clinical sciences into a single tapestry in which everyone from the molecular biologist to the practicing psychiatrist can find and appreciate his or her own research.
Journal ArticleDOI
Astrocyte–endothelial interactions at the blood–brain barrier
TL;DR: Specific interactions between the brain endothelium, astrocytes and neurons that may regulate blood–brain barrier function are explored to lead to the development of new protective and restorative therapies.
Journal ArticleDOI
The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
TL;DR: These findings support developments of new therapeutic approaches for chronic neurodegenerative disorders directed at the blood-brain barrier and other nonneuronal cells of the neurovascular unit.
Journal ArticleDOI
Junctions between intimately apposed cell membranes in the vertebrate brain
TL;DR: Endothelial and epithelial tight junctions occlude the interspaces between blood and parenchyma or cerebral ventricles, thereby constituting a structural basis for the blood-brain and blood-cerebrospinal fluid barriers.
Journal ArticleDOI
The human ATP-binding cassette (ABC) transporter superfamily
TL;DR: The ATP-binding cassette (ABC) transporters are essential for many processes in the cell and mutations in these genes cause or contribute to several human genetic disorders including cystic fibrosis, neurological disease, retinal degeneration, cholesterol and bile transport defects, anemia, and drug response.
Related Papers (5)
Astrocyte–endothelial interactions at the blood–brain barrier
The Blood-Brain Barrier/Neurovascular Unit in Health and Disease
Brian T. Hawkins,Thomas P. Davis +1 more