Journal ArticleDOI
Structure and function of the blood–brain barrier
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TLDR
The structure and function of the BBB is summarised, the physical barrier formed by the endothelial tight junctions, and the transport barrier resulting from membrane transporters and vesicular mechanisms are described.About:
This article is published in Neurobiology of Disease.The article was published on 2010-01-01. It has received 3783 citations till now. The article focuses on the topics: Blood–brain barrier.read more
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Molecular insights and therapeutic targets for blood-brain barrier disruption in ischemic stroke: critical role of matrix metalloproteinases and tissue-type plasminogen activator.
Rong Jin,Guojun Yang,Guohong Li +2 more
TL;DR: An overview of the relationship between structural components and function of the BBB/neurovascular unit with respect to ischemic stroke is provided and therapeutic targeting of MMPs and/or tPA-related signaling pathways might offer promising new approaches to combination therapies for isChemic stroke.
Journal ArticleDOI
Gliomas and the vascular fragility of the blood brain barrier
Luiz Gustavo Dubois,Loraine Campanati,Cassia Righy,Isabella D’Andrea-Meira,Tania Cristina Leite de Sampaio e Spohr,Isabel Porto-Carreiro,Cláudia Pereira,Joana Balça-Silva,Suzana Assad Kahn,Marcos F. DosSantos,Marcela de Almeida Rabello Oliveira,Adriana Ximenes-da-Silva,Maria do Carmo Lopes,Eduardo C. Faveret,Emerson Leandro Gasparetto,Vivaldo Moura-Neto +15 more
TL;DR: Astrocytes, members of the glial family, interact through the exchange of soluble factors or by directly contacting neurons and other brain cells, such as microglia and endothelial cells, and act as additional elements of the Blood Brain Barrier (BBB).
Journal ArticleDOI
Quercetin and related polyphenols: new insights and implications for their bioactivity and bioavailability
TL;DR: A review of the biological aspects and mechanisms of action of quercetin and its related polyphenols is presented in this paper, where new insights into their beneficial health effects on the brain, blood vessels, muscle, and intestine are discussed.
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WNT Signaling in Cardiac and Vascular Disease
Sébastien Foulquier,Evangelos P. Daskalopoulos,Gentian Lluri,Kevin C.M. Hermans,Arjun Deb,W. Matthijs Blankesteijn +5 more
TL;DR: A general picture is emerging that excessive stimulation of WNT signaling adversely affects cardiovascular pathology, and a rapidly increasing collection of drugs interfering at different levels of W NT signaling will allow the evaluation of therapeutic interventions in the pathway in relevant animal models of cardiovascular diseases and eventually in patients in the near future.
Journal ArticleDOI
Brain iron metabolism and its perturbation in neurological diseases.
TL;DR: There is overwhelming evidence for a direct involvement of iron in NDs, with emphasis on recent data linking in particular interactions between iron homeostasis and key disease proteins.
References
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Principles of Neural Science
TL;DR: The editors have done a masterful job of weaving together the biologic, the behavioral, and the clinical sciences into a single tapestry in which everyone from the molecular biologist to the practicing psychiatrist can find and appreciate his or her own research.
Journal ArticleDOI
Astrocyte–endothelial interactions at the blood–brain barrier
TL;DR: Specific interactions between the brain endothelium, astrocytes and neurons that may regulate blood–brain barrier function are explored to lead to the development of new protective and restorative therapies.
Journal ArticleDOI
The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
TL;DR: These findings support developments of new therapeutic approaches for chronic neurodegenerative disorders directed at the blood-brain barrier and other nonneuronal cells of the neurovascular unit.
Journal ArticleDOI
Junctions between intimately apposed cell membranes in the vertebrate brain
TL;DR: Endothelial and epithelial tight junctions occlude the interspaces between blood and parenchyma or cerebral ventricles, thereby constituting a structural basis for the blood-brain and blood-cerebrospinal fluid barriers.
Journal ArticleDOI
The human ATP-binding cassette (ABC) transporter superfamily
TL;DR: The ATP-binding cassette (ABC) transporters are essential for many processes in the cell and mutations in these genes cause or contribute to several human genetic disorders including cystic fibrosis, neurological disease, retinal degeneration, cholesterol and bile transport defects, anemia, and drug response.
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