Journal ArticleDOI
Structure and function of the blood–brain barrier
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TLDR
The structure and function of the BBB is summarised, the physical barrier formed by the endothelial tight junctions, and the transport barrier resulting from membrane transporters and vesicular mechanisms are described.About:
This article is published in Neurobiology of Disease.The article was published on 2010-01-01. It has received 3783 citations till now. The article focuses on the topics: Blood–brain barrier.read more
Citations
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The meningeal and choroidal infiltration routes for leukocytes in stroke
TL;DR: The need to better scrutinize how immune cells are regulated at the blood–brain interface and enter the brain parenchyma, and particularly to also consider alternative cerebral infiltration routes for leukocytes, including the meninges and the choroid plexus, has the potential to develop more effective approaches for anti-inflammatory stroke therapies.
Journal ArticleDOI
Barriers to Effective Drug Treatment for Brain Metastases: A Multifactorial Problem in the Delivery of Precision Medicine
Minjee Kim,Sani H. Kizilbash,Janice K. Laramy,Gautham Gampa,Karen E. Parrish,Jann N. Sarkaria,William F. Elmquist +6 more
TL;DR: Future success in therapeutics for brain metastases must take into account the adequate delivery of “active, free drug” to the target, and may include combinations of targeted drugs that are appropriate to address each individual patient’s tumor type.
Journal ArticleDOI
Non-contrast MR imaging of blood-brain barrier permeability to water
Zixuan Lin,Yang Li,Yang Li,Pan Su,Pan Su,Deng Mao,Deng Mao,Zhiliang Wei,Zhiliang Wei,Jay J. Pillai,Abhay Moghekar,Matthias J.P. van Osch,Yulin Ge,Hanzhang Lu,Hanzhang Lu +14 more
TL;DR: A novel non‐contrast MRI technique is developed for the assessment of blood‐brain barrier permeability to water to develop a novel method to detect subtle changes in BBB permeability.
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Blood–Brain Barrier Imaging in Human Neuropathologies
TL;DR: This review provides an introduction to BBB imaging methods in the clinical scenario, with a focus on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI).
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Modulation of blood-brain barrier permeability in mice using synthetic E-cadherin peptide.
TL;DR: These studies support the potential use of cadherin peptides to rapidly and reversibly modulate BBB permeability of a variety of therapeutic agents.
References
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Journal ArticleDOI
Principles of Neural Science
TL;DR: The editors have done a masterful job of weaving together the biologic, the behavioral, and the clinical sciences into a single tapestry in which everyone from the molecular biologist to the practicing psychiatrist can find and appreciate his or her own research.
Journal ArticleDOI
Astrocyte–endothelial interactions at the blood–brain barrier
TL;DR: Specific interactions between the brain endothelium, astrocytes and neurons that may regulate blood–brain barrier function are explored to lead to the development of new protective and restorative therapies.
Journal ArticleDOI
The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
TL;DR: These findings support developments of new therapeutic approaches for chronic neurodegenerative disorders directed at the blood-brain barrier and other nonneuronal cells of the neurovascular unit.
Journal ArticleDOI
Junctions between intimately apposed cell membranes in the vertebrate brain
TL;DR: Endothelial and epithelial tight junctions occlude the interspaces between blood and parenchyma or cerebral ventricles, thereby constituting a structural basis for the blood-brain and blood-cerebrospinal fluid barriers.
Journal ArticleDOI
The human ATP-binding cassette (ABC) transporter superfamily
TL;DR: The ATP-binding cassette (ABC) transporters are essential for many processes in the cell and mutations in these genes cause or contribute to several human genetic disorders including cystic fibrosis, neurological disease, retinal degeneration, cholesterol and bile transport defects, anemia, and drug response.
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