Journal ArticleDOI
Structure and function of the blood–brain barrier
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TLDR
The structure and function of the BBB is summarised, the physical barrier formed by the endothelial tight junctions, and the transport barrier resulting from membrane transporters and vesicular mechanisms are described.About:
This article is published in Neurobiology of Disease.The article was published on 2010-01-01. It has received 3783 citations till now. The article focuses on the topics: Blood–brain barrier.read more
Citations
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Regulation of neuroblast proliferation by surface glia in the Drosophila larval brain.
Makoto I. Kanai,Myung Jun Kim,Takuya Akiyama,Masahiko Takemura,Kristi A. Wharton,Michael B. O'Connor,Hiroshi Nakato +6 more
TL;DR: This study shows that the surface glia in the developing Drosophila brain plays essential roles in regulating the proliferation of neural stem cells, neuroblasts (NBs), and proposes that bidirectional communication between NBs and glia through TGF-β signaling influences mutual development of these two cell types.
Journal ArticleDOI
Blood borne hormones in a cross-talk between peripheral and brain mechanisms regulating blood pressure, the role of circumventricular organs.
Marcin Ufnal,Janusz Skrzypecki +1 more
TL;DR: Studies on hemodynamic effects of catecholamines, neuropeptide Y, angiotensin II, aldosterone, natriuretic peptides, endothelins, histamine and bradykinin are reviewed in the context of their role in a cross-talk between peripheral and brain mechanisms involved in the regulation of arterial blood pressure.
Journal ArticleDOI
Pericytes from Mesenchymal Stem Cells as a model for the blood-brain barrier.
TL;DR: Results indicated that MSC contributed in a similar manner to pericytes in a co-cultured 3D model on increasing trans-endothelial electric resistance (TEER) and decreasing permeability against macromolecules.
Journal ArticleDOI
Coexistence of passive and proton antiporter-mediated processes in nicotine transport at the mouse blood-brain barrier.
Salvatore Cisternino,Hélène Chapy,Pascal André,Maria Smirnova,Marcel Debray,Jean-Michel Scherrmann +5 more
TL;DR: In vivo manipulation of intracellular and/or extracellular pH, the chemical inhibition profile, and the trans-stimulation experiments demonstrated that the nicotine transporter at the BBB shared the properties of the clonidine/proton antiporter.
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Tetramethylpyrazine Protects Against Oxygen-Glucose Deprivation-Induced Brain Microvascular Endothelial Cells Injury via Rho/Rho-kinase Signaling Pathway
Guang Yang,Guang Yang,Chen Qian,Chen Qian,Ning Wang,Ning Wang,Chenyu Lin,Chenyu Lin,Yan Wang,Yan Wang,Guang-Yun Wang,Guang-Yun Wang,Xin-Xin Piao,Xin-Xin Piao +13 more
TL;DR: Investigating the protective mechanisms of TMP shows that TMP has a strong protective effect against OGD-induced BMECs injury and suggests that the mechanism might be related to the inhibition of the Rho/ROCK signaling pathway.
References
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Principles of Neural Science
TL;DR: The editors have done a masterful job of weaving together the biologic, the behavioral, and the clinical sciences into a single tapestry in which everyone from the molecular biologist to the practicing psychiatrist can find and appreciate his or her own research.
Journal ArticleDOI
Astrocyte–endothelial interactions at the blood–brain barrier
TL;DR: Specific interactions between the brain endothelium, astrocytes and neurons that may regulate blood–brain barrier function are explored to lead to the development of new protective and restorative therapies.
Journal ArticleDOI
The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
TL;DR: These findings support developments of new therapeutic approaches for chronic neurodegenerative disorders directed at the blood-brain barrier and other nonneuronal cells of the neurovascular unit.
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Junctions between intimately apposed cell membranes in the vertebrate brain
TL;DR: Endothelial and epithelial tight junctions occlude the interspaces between blood and parenchyma or cerebral ventricles, thereby constituting a structural basis for the blood-brain and blood-cerebrospinal fluid barriers.
Journal ArticleDOI
The human ATP-binding cassette (ABC) transporter superfamily
TL;DR: The ATP-binding cassette (ABC) transporters are essential for many processes in the cell and mutations in these genes cause or contribute to several human genetic disorders including cystic fibrosis, neurological disease, retinal degeneration, cholesterol and bile transport defects, anemia, and drug response.
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