Journal ArticleDOI
Structure and function of the blood–brain barrier
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TLDR
The structure and function of the BBB is summarised, the physical barrier formed by the endothelial tight junctions, and the transport barrier resulting from membrane transporters and vesicular mechanisms are described.About:
This article is published in Neurobiology of Disease.The article was published on 2010-01-01. It has received 3783 citations till now. The article focuses on the topics: Blood–brain barrier.read more
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The Blood-Brain Barrier
TL;DR: It is clarified that a BBB for solutes is neither mechanistically equal to a barrier for immune cells nor in regard to the sites of entry (capillaries versus post-capillary venules), formulate areas of lack of knowledge and consequently, raise open questions to be addressed in the future.
Journal ArticleDOI
Favorable outcome in infants with AML after intensive first- and second-line treatment: an AML-BFM study group report
Ursula Creutzig,M Zimmermann,J-P Bourquin,Michael Dworzak,Bernhard Kremens,Thomas Lehrnbecher,von Neuhoff C,Annette Sander,von Stackelberg A,Irene Schmid,Jan Starý,Daniel Steinbach,Josef Vormoor,Dirk Reinhardt +13 more
TL;DR: The data indicate that intensive frontline and relapse AML treatment is feasible in infants, toxicities are manageable, and outcome is favorable.
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The need for mathematical modelling of spatial drug distribution within the brain
TL;DR: There is a need for a more comprehensive and integrated model that fills the current gaps in predicting the local drug distribution within the brain, according to system-specific and drug-specific properties that affect the local distribution of drugs in the brain.
Journal ArticleDOI
Mechanisms That Determine the Internal Environment of the Developing Brain: A Transcriptomic, Functional and Ultrastructural Approach
Shane A. Liddelow,Shane A. Liddelow,Katarzyna M. Dziegielewska,C. Joakim Ek,Mark D. Habgood,Hannelore Bauer,Hans-Christian Bauer,Hans-Christian Bauer,Helen Lindsay,Helen Lindsay,Matthew Wakefield,Matthew Wakefield,Nathalie Strazielle,Ingrid Kratzer,Kjeld Møllgård,Jean-François Ghersi-Egea,Norman R. Saunders +16 more
TL;DR: It is shown that exchange between blood and CSF is mainly transcellular, as well-formed tight junctions restrict movement of small water-soluble molecules from early in development, which strongly indicates the brain develops within a well-protected internal environment and the exchange between the blood, brain andCSF is trans cellular.
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Extracellular Membrane Vesicles as Vehicles for Brain Cell-to-Cell Interactions in Physiological as well as Pathological Conditions.
TL;DR: Possible roles of EVs in brain physiological functions are summarized and their involvement in the horizontal spreading, from cell to cell, of both cancer and neurodegenerative pathologies is discussed.
References
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Principles of Neural Science
TL;DR: The editors have done a masterful job of weaving together the biologic, the behavioral, and the clinical sciences into a single tapestry in which everyone from the molecular biologist to the practicing psychiatrist can find and appreciate his or her own research.
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Astrocyte–endothelial interactions at the blood–brain barrier
TL;DR: Specific interactions between the brain endothelium, astrocytes and neurons that may regulate blood–brain barrier function are explored to lead to the development of new protective and restorative therapies.
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The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
TL;DR: These findings support developments of new therapeutic approaches for chronic neurodegenerative disorders directed at the blood-brain barrier and other nonneuronal cells of the neurovascular unit.
Journal ArticleDOI
Junctions between intimately apposed cell membranes in the vertebrate brain
TL;DR: Endothelial and epithelial tight junctions occlude the interspaces between blood and parenchyma or cerebral ventricles, thereby constituting a structural basis for the blood-brain and blood-cerebrospinal fluid barriers.
Journal ArticleDOI
The human ATP-binding cassette (ABC) transporter superfamily
TL;DR: The ATP-binding cassette (ABC) transporters are essential for many processes in the cell and mutations in these genes cause or contribute to several human genetic disorders including cystic fibrosis, neurological disease, retinal degeneration, cholesterol and bile transport defects, anemia, and drug response.
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