SUFU suppresses ferroptosis sensitivity in breast cancer cells via Hippo/YAP pathway
Kun Fang,Shan Du,Dachuan Shen,Zhipeng Xiong,Ke Jiang,Dapeng Liang,Jianxin Wang,Huizhe Xu,Lulu Hu,Xingyue Zhai,Yuting Jiang,Zhiyu Xia,Chunrui Xie,Dingli Jin,Wei Chen,Songshu Meng,Yifei Wang +16 more
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TLDR
In this paper , the Suppressor of fused homolog (SUFU), a critical component in Hedgehog signaling, regulates ferroptosis sensitivity of breast cancer cells, and SUFU depletion promoted the activation of Yes-associated protein (YAP), thereby increasing the expression of ACSL4.About:
This article is published in iScience.The article was published on 2022-06-01 and is currently open access. It has received 7 citations till now. The article focuses on the topics: Medicine & Chemistry.read more
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COVID-19 Causes Ferroptosis and Oxidative Stress in Human Endothelial Cells
S. S. Jankauskas,Urna Kansakar,Celestino Sardu,Fahimeh Varzideh,Roberta Avvisato,Xujun Wang,Alessandro Matarese,Raffaele Marfella,Marcello Ziosi,Jessica Gambardella,Gaetano Santulli +10 more
TL;DR: In this paper , the authors investigated the impact of COVID-19 on lipid peroxidation and ferroptosis in human endothelial cells and found that the serum from non-survivors significantly increased lipid peroxide.
Journal ArticleDOI
TEA Domain Transcription Factor 1 Inhibits Ferroptosis and Sorafenib Sensitivity of Hepatocellular Carcinoma Cells
TL;DR: In this paper , the role and molecular mechanism of TEA domain transcription factor 1 (TEAD1) in HCC and its effect on sorafenib-induced ferroptosis were investigated.
Journal ArticleDOI
The gene regulatory molecule GLIS3 in gastric cancer as a prognostic marker and be involved in the immune infiltration mechanism
TL;DR: In this paper , the authors examined the prognostic significance of GLIS3 and its association with immune infiltration in gastric cancer using univariate and multivariate Cox regression analyses, independent prognostic variables were identified, and a nomogram model was built.
Journal ArticleDOI
Lobetyolin Alleviates Ferroptosis of Skeletal Muscle in 5/6 Nephrectomized Mice via Activation of Hedgehog-GLI1 Signaling.
Shi-Hao Ni,Xiao-Jiao Zhang,Sirui Li,Xiaochao Ouyang,Jin Hong Li,Yu Li,Shu-Ning Sun,Xiao Han,W. J. Long,Lingjun Wang,Zhongqi Yang,Lu Lu +11 more
TL;DR: In this article , Liu et al. explored whether ferroptosis is present in the skeletal muscle of 5/6 nephrectomized (NPM) mice via RNA-Seq analysis, TUNEL staining, Oil red O staining and MDA/GSH/GSSG level detection and real-time quantitative PCR (qPCR).
Journal ArticleDOI
Ferroptosis-Related Proteins Are Potential Diagnostic Molecular Markers for Patients with Preeclampsia
M. F. Shi,Xiaofeng Yang,Yuzhen Ding,Lu Sun,Ping Zhang,Mengyuan Liu,Xiaoxue Han,Zhengrui Huang,Ruiman Li +8 more
TL;DR: This study identified that two key genes, p53 and c-Jun, might be potential diagnostic biomarkers of PE, and selected them based on the relationship between their expression levels and clinicopathologic features and diagnosis value using the ROC curve.
References
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Journal ArticleDOI
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Scott J. Dixon,Kathryn M. Lemberg,Michael R. Lamprecht,Rachid Skouta,Eleina M. Zaitsev,Caroline E Gleason,Darpan N Patel,Andras J. Bauer,Alexandra M. Cantley,Wan Seok Yang,Barclay Morrison,Brent R. Stockwell,Brent R. Stockwell +12 more
TL;DR: This paper identified the small molecule ferrostatin-1 as a potent inhibitor of ferroptosis in cancer cells and glutamate-induced cell death in organotypic rat brain slices, suggesting similarities between these two processes.
Journal ArticleDOI
Role of YAP/TAZ in mechanotransduction
Sirio Dupont,Leonardo Morsut,Mariaceleste Aragona,Elena Enzo,Stefano Giulitti,Michelangelo Cordenonsi,Francesca Zanconato,Jimmy Le Digabel,Mattia Forcato,Silvio Bicciato,Nicola Elvassore,Stefano Piccolo +11 more
TL;DR: YAP/TAZ are identified as sensors and mediators of mechanical cues instructed by the cellular microenvironment and are functionally required for differentiation of mesenchymal stem cells induced by ECM stiffness and for survival of endothelial cells regulated by cell geometry.
Journal ArticleDOI
Regulation of Ferroptotic Cancer Cell Death by GPX4
Wan Seok Yang,Rohitha SriRamaratnam,Matthew Welsch,Kenichi Shimada,Rachid Skouta,Vasanthi S. Viswanathan,Vasanthi S. Viswanathan,Jaime H. Cheah,Paul A. Clemons,Alykhan F. Shamji,Clary B. Clish,Lewis M. Brown,Albert W. Girotti,Virginia W. Cornish,Stuart L. Schreiber,Brent R. Stockwell +15 more
TL;DR: Targeted metabolomic profiling and chemoproteomics revealed that GPX4 is an essential regulator of ferroptotic cancer cell death and sensitivity profiling in 177 cancer cell lines revealed that diffuse large B cell lymphomas and renal cell carcinomas are particularly susceptible to GPx4-regulated ferroPTosis.
Journal ArticleDOI
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
Bin Zhao,Xiaomu Wei,Weiquan Li,Ryan S. Udan,Ryan S. Udan,Qian Yang,Joungmok Kim,Joungmok Kim,Joe Xie,Tsuneo Ikenoue,Jindan Yu,Li Li,Li Li,Pan Zheng,Keqiang Ye,Arul M. Chinnaiyan,Georg Halder,Georg Halder,Zhi Chun Lai,Kun-Liang Guan,Kun-Liang Guan +20 more
TL;DR: It is demonstrated that in mammalian cells, the transcription coactivator YAP (Yes-associated protein), is inhibited by cell density via the Hippo pathway, and YAP overexpression regulates gene expression in a manner opposite to cell density, and is able to overcome cell contact inhibition.
Journal ArticleDOI
TEAD mediates YAP-dependent gene induction and growth control
Bin Zhao,Xin Ye,Jindan Yu,Li Li,Li Li,Weiquan Li,Siming Li,Jianjun Yu,Jiandie D. Lin,Cun-Yu Wang,Arul M. Chinnaiyan,Zhi Chun Lai,Kun-Liang Guan +12 more
TL;DR: TEAD is revealed as a new component in the Hippo pathway playing essential roles in mediating biological functions of YAP, and is required for YAP-induced cell growth, oncogenic transformation, and epithelial-mesenchymal transition.