Superior T memory stem cell persistence supports long-lived T cell memory
Enrico Lugli,Maria H. Dominguez,Luca Gattinoni,Pratip K. Chattopadhyay,Diane L. Bolton,Kaimei Song,Nichole R. Klatt,Jason M. Brenchley,Monica Vaccari,Emma Gostick,David Price,Thomas A. Waldmann,Nicholas P. Restifo,Genoveffa Franchini,Mario Roederer +14 more
TLDR
Vaccination strategies designed to elicit durable cellular immunity should target the generation of TSCM cells, which were generated in the acute phase of viral infection, preferentially survived in comparison with all other memory cells following elimination of antigen, and stably persisted for the long term.Abstract:
Long-lived memory T cells are able to persist in the host in the absence of antigen; however, the mechanism by which they are maintained is not well understood. Recently, a subset of human T cells, stem cell memory T cells (TSCM cells), was shown to be self-renewing and multipotent, thereby providing a potential reservoir for T cell memory throughout life. However, their in vivo dynamics and homeostasis still remain to be defined due to the lack of suitable animal models. We identified T cells with a TSCM phenotype and stem cell–like properties in nonhuman primates. These cells were the least-differentiated memory subset, were functionally distinct from conventional memory cells, and served as precursors of central memory. Antigen-specific TSCM cells preferentially localized to LNs and were virtually absent from mucosal surfaces. They were generated in the acute phase of viral infection, preferentially survived in comparison with all other memory cells following elimination of antigen, and stably persisted for the long term. Thus, one mechanism for maintenance of long-term T cell memory derives from the unique homeostatic properties of TSCM cells. Vaccination strategies designed to elicit durable cellular immunity should target the generation of TSCM cells.read more
Citations
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Journal ArticleDOI
Human memory T cells: generation, compartmentalization and homeostasis
TL;DR: Studies focused on human memory T cells that reveal key properties of these cells, including subset heterogeneity and diverse tissue residence in multiple mucosal and lymphoid tissue sites are discussed.
Journal ArticleDOI
The who's who of T-cell differentiation: human memory T-cell subsets.
TL;DR: Recent developments in the characterization of the heterogeneity of the memory T‐cell compartment are reviewed, and a unified classification of both human and nonhuman primate T cells on the basis of phenotypic traits and in vivo properties is proposed.
Journal ArticleDOI
JAK/STAT3-Regulated Fatty Acid β-Oxidation Is Critical for Breast Cancer Stem Cell Self-Renewal and Chemoresistance.
Tianyi Wang,Tianyi Wang,Johannes F. Fahrmann,Heehyoung Lee,Yi Jia Li,Satyendra C. Tripathi,Chanyu Yue,Chunyan Zhang,Veronica Lifshitz,Jieun Song,Yuan Yuan,George Somlo,Rahul Jandial,David K. Ann,Samir M. Hanash,Richard Jove,Hua Yu +16 more
TL;DR: It is demonstrated that JAK/STAT3 regulates lipid metabolism, which promotes breast CSCs (BCSCs) and cancer chemoresistance, and human breast-cancer-derived data suggest that the STAT3-CPT1B-FAO pathway promotes cancer cell stemness and Chemoresistance.
Journal ArticleDOI
HIV-1 persistence in CD4+ T cells with stem cell-like properties
Maria J. Buzon,Hong Sun,Chun Li,Amy Shaw,Katherine Seiss,Zhengyu Ouyang,Enrique Martin-Gayo,Jin Leng,Timothy J. Henrich,Jonathan Z. Li,Florencia Pereyra,Ryan Zurakowski,Bruce D. Walker,Eric S. Rosenberg,Xu G. Yu,Mathias Lichterfeld +15 more
TL;DR: HIV-1 may exploit the stem cell characteristics of cellular immune memory to promote long-term viral persistence of viral quasispecies in CD4+ TSCM cells.
Journal ArticleDOI
T memory stem cells in health and disease
TL;DR: Emerging findings demonstrating that TSCM cells, owing to their extreme longevity and robust potential for immune reconstitution, are central players in many physiological and pathological human processes are described.
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