Supplementation of 1-Kestose Modulates the Gut Microbiota Composition to Ameliorate Glucose Metabolism in Obesity-Prone Hosts.
Ayako Watanabe,Takumi Tochio,Yoshihiro Kadota,Motoki Takahashi,Yasuyuki Kitaura,Hirohito Ishikawa,Takanori Yasutake,Masahiro Nakano,Hiroe Shinohara,Kudo Toru,Yuichiro Nishimoto,Yoshinori Mizuguchi,Akihito Endo,Yoshiharu Shimomura +13 more
TLDR
In this paper, the prebiotic effect of 1-kestose supplementation on fasting insulin concentration in obesity-prone humans and rats was investigated, and it was shown that 1-Kestose supplements may potentially ameliorate insulin resistance in overweight humans via modulation of the gut microbiota.Abstract:
Insulin resistance leads to the onset of medical conditions such as type 2 diabetes, and its development is associated with the alteration in the gut microbiota. Although it has been demonstrated that supplementation with prebiotics modulates the gut microbiota, limited evidence is available for effects of prebiotics on insulin resistance, especially for humans. We investigated the prebiotic effect of 1-kestose supplementation on fasting insulin concentration in obesity-prone humans and rats. In the preliminary study using rats, the hyperinsulinemia induced by high-fat diet was suppressed by intake of water with 2% (w/v) 1-kestose. In the clinical study using obese-prone volunteers, the fasting serum insulin level was significantly reduced from 6.5 µU/mL (95% CI, 5.5-7.6) to 5.3 (4.6-6.0) by the 12-week intervention with supplementation of 10 g 1-kestose/day, whereas it was not changed by the intervention with placebo (6.2 µU/mL (5.4-7.1) and 6.5 (5.5-7.6) before and after intervention, respectively). The relative abundance of fecal Bifidobacterium was significantly increased to 0.3244 (SD, 0.1526) in 1-kestose-supplemented participants compared to that in control participants (0.1971 (0.1158)). These results suggest that prebiotic intervention using 1-kestose may potentially ameliorate insulin resistance in overweight humans via the modulation of the gut microbiota. UMIN 000028824.read more
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Gut Microbiota: An Important Player in Type 2 Diabetes Mellitus
TL;DR: It is suggested that T2DM and its complications can be treated by remodeling the gut microbiota through interventions such as drugs, probiotics, prebiotics, fecal microbiota transplantation (FMT) and diets.
Journal ArticleDOI
Could foodomics hold the key to unlocking the role of prebiotics in gut microbiota and immunity?
TL;DR: In this article , a review discusses how omics technologies can be used in prebiotics research. But the authors do not discuss how to apply omics technology to prebiotic research.
Journal ArticleDOI
Gut microbiota and obesity: New insights
Yoredy Sarmiento-Andrade,Rosario Suárez,Beatriz Quintero,Kleber Garrochamba,Sebastián Pablo Chapela +4 more
TL;DR: The biology and physiology of microbiota in obese patients, its role in the pathophysiology of several disorders associated, and the emerging therapeutic applications of prebiotics, probiotics, and fecal microbiota transplantation are summarized.
Journal ArticleDOI
Efficacy of 1‐kestose supplementation in patients with mild to moderate ulcerative colitis: A randomised, double‐blind, placebo‐controlled pilot study
Shuji Ikegami,Masanori Nakamura,Takashi Honda,T. Yamamura,Keiko Maeda,Tsunaki Sawada,Eri Ishikawa,Kenta Yamamoto,Satoshi Furune,Takuya Ishikawa,Kazuhiro Furukawa,Eizaburo Ohno,Masatoshi Ishigami,Fumie Kinoshita,Yoshihiro Kadota,Takumi Tochio,Yoshiharu Shimomura,Yoshiki Hirooka,Hiroki Kawashima +18 more
TL;DR: In this article , a prebiotic 1 kestose is administered to active ulcerative colitis patients, which involves an excessive immune response to intestinal bacteria, and it is shown to be effective for active colitis.
Journal ArticleDOI
Starch and Fiber Contents of Purified Control Diets Differentially Affect Hepatic Lipid Homeostasis and Gut Microbiota Composition
TL;DR: Carohydrate-rich purified diets trigger a metabolic status possibly masking pathological effects of nutrients under study, restricting its use as control condition, and the addition of refined fibers is suited to create purified, yet physiological control diets for DIO research.
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TL;DR: QIIME 2 development was primarily funded by NSF Awards 1565100 to J.G.C. and R.K.P. and partial support was also provided by the following: grants NIH U54CA143925 and U54MD012388.
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