Journal ArticleDOI
Surface design of magnetic nanoparticles for stimuli-responsive cancer imaging and therapy.
TLDR
Stimuli-responsive ligands, rationally designed to interact with various physicochemical aspects, can improve the performance of MNPs in cancer-targeted imaging and therapy.About:
This article is published in Biomaterials.The article was published on 2017-08-01. It has received 231 citations till now. The article focuses on the topics: Nanomedicine.read more
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Photosensitizers with Aggregation-Induced Emission: Materials and Biomedical Applications
Fang Hu,Shidang Xu,Bin Liu +2 more
TL;DR: In this paper, the design principles of aggregation-induced emission (AIE) PSs and their biomedical applications are discussed in detail, starting with a summary of traditional PSs, followed by a comparison between traditional and AIE PSs to highlight various design strategies and unique features of the latter.
Journal Article
Photosensitizers with Aggregation-Induced Emission: Materials and Biomedical Applications
Fang Hu,Shidang Xu,Bin Liu +2 more
TL;DR: The design principles of AIE PSs and their biomedical applications are discussed in detail, starting with a summary of traditional PSs, followed by a comparison between traditional and AIEPSs to highlight the various design strategies and unique features of the latter.
Journal ArticleDOI
Structure-Relaxivity Relationships of Magnetic Nanoparticles for Magnetic Resonance Imaging.
TL;DR: Recent progress in probing MRI relaxivity of MNPs based on structural features at the molecular and atomic scales is reviewed and a special emphasis is placed on bridging the gaps between classical simplistic models and modern MNPs with elegant structural complexity.
Journal ArticleDOI
Engineering nanomedicine for glutathione depletion-augmented cancer therapy
TL;DR: The most recent progress in engineering nanomedicine for GSH depletion-enhanced cancer therapies, by simultaneously delivering GSH-depleting agents and therapeutic components, is summarized.
Journal ArticleDOI
Cyclodextrin-Based Multistimuli-Responsive Supramolecular Assemblies and Their Biological Functions.
TL;DR: In this review, recent progress in CD‐based supramolecular nano assemblies that are sensitive to chemical, biological, and physical stimuli is updated and reviewed, and intriguing examples of the biological functions of these nanoassemblies are presented.
References
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Nanocarriers as an emerging platform for cancer therapy
Dan Peer,Jeffrey M. Karp,Jeffrey M. Karp,Seungpyo Hong,Omid C. Farokhzad,Rimona Margalit,Robert Langer +6 more
TL;DR: The arsenal of nanocarriers and molecules available for selective tumour targeting, and the challenges in cancer treatment are detailed and emphasized.
Journal ArticleDOI
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Scott J. Dixon,Kathryn M. Lemberg,Michael R. Lamprecht,Rachid Skouta,Eleina M. Zaitsev,Caroline E Gleason,Darpan N Patel,Andras J. Bauer,Alexandra M. Cantley,Wan Seok Yang,Barclay Morrison,Brent R. Stockwell,Brent R. Stockwell +12 more
TL;DR: This paper identified the small molecule ferrostatin-1 as a potent inhibitor of ferroptosis in cancer cells and glutamate-induced cell death in organotypic rat brain slices, suggesting similarities between these two processes.
Journal Article
A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs
Yasuhiro Matsumura,Hiroshi Maeda +1 more
TL;DR: It is speculated that the tumoritropic accumulation of smancs and other proteins resulted because of the hypervasculature, an enhanced permeability to even macromolecules, and little recovery through either blood vessels or lymphatic vessels in tumors of tumor-bearing mice.
Journal ArticleDOI
Emerging applications of stimuli-responsive polymer materials
Martien A. Cohen Stuart,Wilhelm T. S. Huck,Jan Genzer,Marcus Müller,Christopher K. Ober,Manfred Stamm,Gleb B. Sukhorukov,Igal Szleifer,Vladimir V. Tsukruk,Marek W. Urban,Françoise M. Winnik,Stefan Zauscher,Igor Luzinov,Sergiy Minko +13 more
TL;DR: This work reviews recent advances and challenges in the developments towards applications of stimuli-responsive polymeric materials that are self-assembled from nanostructured building blocks and provides a critical outline of emerging developments.
Journal ArticleDOI
Stimuli-responsive nanocarriers for drug delivery
TL;DR: Recent advances in the design of nanoscale stimuli-responsive systems that are able to control drug biodistribution in response to specific stimuli, either exogenous (variations in temperature, magnetic field, ultrasound intensity, light or electric pulses) or endogenous (changes in pH, enzyme concentration or redox gradients).