Journal ArticleDOI
Targeted therapy of cancer using diphtheria toxin-derived immunotoxins
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TLDR
Continuous efforts are being made to investigate molecules exclusively expressed on cancer cells, to improve the specificity and efficacy of these immunotoxins, and to eliminate side effects and improve pharmacokinetics and ensure better drug delivery.About:
This article is published in Drug Discovery Today.The article was published on 2008-09-01. It has received 58 citations till now. The article focuses on the topics: Targeted therapy & Cancer.read more
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Humanized immunotoxins: A new generation of immunotoxins for targeted cancer therapy
TL;DR: A novel generation of immunotoxins in which the cytotoxic moiety is an endogenous protein of human origin like proapoptotic protein or RNase has been developed, and a review summarizes the advances in this new class of fusion protein and the future directions to be explored.
Journal ArticleDOI
Ribosome-Inactivating Proteins: From Plant Defense to Tumor Attack
TL;DR: The most promising way to exploit plant RIPs as weapons against cancer cells is either by designing molecules in which the toxic domains are linked to selective tumor targeting domains or directly delivered as suicide genes for cancer gene therapy.
Journal ArticleDOI
Protein toxins from plants and bacteria: probes for intracellular transport and tools in medicine.
Kirsten Sandvig,Kirsten Sandvig,Maria Lyngaas Torgersen,Maria Lyngaas Torgersen,Nikolai Engedal,Nikolai Engedal,Tore Skotland,Tore Skotland,Tore Geir Iversen,Tore Geir Iversen +9 more
TL;DR: Toxins are valuable tools to discover and characterize cellular processes such as endocytosis and intracellular transport and Interestingly, toxins can be used for diagnosis and treatment of cancer.
Journal ArticleDOI
Toxin-based therapeutic approaches.
Assaf Shapira,Itai Benhar +1 more
TL;DR: The following review summarizes major advances in the field of toxin based therapeutics and offers a comprehensive description of the mode of action of each applied toxin.
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Immunotoxins in cancer therapy: Review and update.
Bahman Akbari,Safar Farajnia,Shiva Ahdi Khosroshahi,Fatemeh Safari,Mohammad Reza Yousefi,Hassan Dariushnejad,Leila Rahbarnia +6 more
TL;DR: The advantages and limitations of bacterial toxinssuch as Pseudomonas and Diphtheria toxins, plant toxins such as ricin and gelonin, and some endogenous protein of human origin such as RNases and Granzymes are discussed.
References
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Journal ArticleDOI
Bacteriocins of gram-positive bacteria.
TL;DR: A group of antibacterial proteins produced by gram-positive bacteria have attracted great interest in their potential use as food preservatives and as antibacterial agents to combat certain infections due to gram- positive pathogenic bacteria.
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Cytokines in cancer pathogenesis and cancer therapy
TL;DR: The mixture of cytokines that is produced in the tumour microenvironment has an important role in cancer pathogenesis and provides new opportunities for improving cancer immunotherapy.
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Interferons, immunity and cancer immunoediting.
TL;DR: The roles of the IFNs are discussed, not only in cancer immunosurveillance but also in the broader process of cancer immunoediting.
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A humanized antibody that binds to the interleukin 2 receptor.
Cary L. Queen,William P. Schneider,Harold E. Selick,Philip W. Payne,Nicholas F. Landolfi,James F. Duncan,Nevenka M. Avdalovic,Michael Levitt,Richard P. Junghans,Thomas A. Waldmann +9 more
TL;DR: A "humanized" antibody is constructed by combining the complementarity-determining regions (CDRs) of the anti-Tac antibody with human framework and constant regions and has an affinity for p55 of 3 x 10(9) M-1, about 1/3 that of murine anti- Tac.