Journal ArticleDOI
The 350-fold compacted Fugu parkin gene is structurally and functionally similar to human Parkin.
Wei-Ping Yu,Jeanne M.M. Tan,Katherine C. M. Chew,Tania Oh,Prasanna R. Kolatkar,Byrappa Venkatesh,Ted M. Dawson,Kah-Leong Lim +7 more
TLDR
It is suggested that the physiological function and regulation of the parkin gene are conserved during the evolution of vertebrates and the compact locus of fuparkin could serve as a useful model to understand the transcriptional regulation of huParkin.About:
This article is published in Gene.The article was published on 2005-02-14. It has received 5 citations till now. The article focuses on the topics: Parkin & Fugu.read more
Citations
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Book ChapterDOI
Cellular and molecular approaches to the investigation of piscine osmoregulation: Current and future perspectives
Journal ArticleDOI
Repertoire of Protein Kinases Encoded in the Genome of Takifugu rubripes.
Ramaswamy Rakshambikai,Subburaj Yamunadevi,Subburaj Yamunadevi,Subburaj Yamunadevi,Krishanpal Anamika,Krishanpal Anamika,Nidhi Tyagi,Nidhi Tyagi,Narayanaswamy Srinivasan +8 more
TL;DR: Overall the fugu serves as a good model organism to understand roles of human kinases as far as kinases such as LRRK and IRAK and their associated pathways are concerned.
Journal ArticleDOI
Fugu rubripes and human survival motor neuron genes: Structural and functional similarities in comparative genome studies
TL;DR: Cloned and analyzed the Fugu survival motor neuron gene (fsmn) for similarities with human SMN gene (huSMN) to indicate close structural and functional similarities between fsmn and huSMN, suggesting that regulation of the two genes may also be similar and supporting the use of f smn in comparative genome studies for the identification of functional regulatory elements of hu SMN.
DissertationDOI
Investigation of Cis and Trans-acting Transcriptional Regulatory Factors and Signaling Pathways of Parkin
TL;DR: This chapter discusses the association of human Parkin gene (PARK2) with Parkinson’s disease, the structure and function of Nrf2 transcription factor 22, and challenges in studying the transcriptional regulation ofhuman Parkin.
References
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Journal ArticleDOI
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
Tohru Kitada,Shuichi Asakawa,Nobutaka Hattori,Hiroto Matsumine,Yasuhiro Yamamura,Shinsei Minoshima,Masayuki Yokochi,Yoshikuni Mizuno,Nobuyoshi Shimizu +8 more
TL;DR: Mutations in the newly identified gene appear to be responsible for the pathogenesis of Autosomal recessive juvenile parkinsonism, and the protein product is named ‘Parkin’.
Journal ArticleDOI
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
Hideki Shimura,Nobutaka Hattori,Shin-ichiro Kubo,Yoshikuni Mizuno,Shuichi Asakawa,Shinsei Minoshima,Nobuyoshi Shimizu,Kazuhiro Iwai,Tomoki Chiba,Keiji Tanaka,Toshiaki Suzuki +10 more
TL;DR: The findings indicate that accumulation of proteins that have yet to be identified causes a selective neural cell death without formation of Lewy bodies, and should enhance the exploration of the molecular mechanisms of neurodegeneration in Parkinson disease as well as in other Neurodegenerative diseases that are characterized by involvement of abnormal protein ubiquitination.
Journal ArticleDOI
Whole-Genome Shotgun Assembly and Analysis of the Genome of Fugu rubripes
Samuel Aparicio,Jarrod Chapman,Elia Stupka,Nik Putnam,Jer Ming Chia,Paramvir S. Dehal,Alan Christoffels,Sam Rash,Shawn Hoon,Arian F.A. Smit,Maarten D. Sollewijn Gelpke,Jared C. Roach,Tania Oh,Isaac Ho,Marie Wong,Chris Detter,Frans Verhoef,Paul Predki,Alice Tay,Susan Lucas,Paul G. Richardson,Sarah Smith,Melody S. Clark,Yvonne J. K. Edwards,Norman A. Doggett,Andrey Zharkikh,Sean V. Tavtigian,Dmitry Pruss,Mary Barnstead,Cheryl Evans,Holly Baden,Justin Powell,Gustavo Glusman,Lee Rowen,Leroy Hood,Y. H. Tan,Greg Elgar,Trevor Hawkins,Byrappa Venkatesh,Daniel S. Rokhsar,Sydney Brenner +40 more
TL;DR: The Fugu rubripes genome has been sequenced to over 95% coverage, and more than 80% of the assembly is in multigene-sized scaffolds as discussed by the authors.
Journal ArticleDOI
Association between Early-Onset Parkinson's Disease and Mutations in the Parkin Gene
C. B. Lücking,Alexandra Durr,Bonifati,J. R. Vaughan,G. De Michele,Thomas Gasser,Biswadjiet S. Harhangi,Giuseppe Meco,Patrice Denefle,Nicholas W. Wood,Yves Agid,Alexis Brice,French Parkinsons Dis Genetics Stu +12 more
TL;DR: Mutations in the parkin gene are a major cause of early-onset autosomal recessive familial Parkinson's disease and isolated juvenile-ONSet Parkinson's Disease and accurate diagnosis of these cases cannot be based only on the clinical manifestations of the disease.
Journal ArticleDOI
Parkin functions as an E2-dependent ubiquitin– protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1
TL;DR: It is suggested that Parkin functions as an E3 ubiquitin-protein ligase through its ring domains and that it may control protein levels via ubiquitination.
Related Papers (5)
clueless, a conserved Drosophila gene required for mitochondrial subcellular localization, interacts genetically with parkin
Rachel T. Cox,Allan C. Spradling +1 more