Journal ArticleDOI
The action potential in mammalian central neurons
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TLDR
The action potential of the squid giant axon is formed by just two voltage-dependent conductances in the cell membrane, yet mammalian central neurons typically express more than a dozen different types of voltage- dependent ion channels.Abstract:
The action potential of the squid giant axon is formed by just two voltage- dependent conductances in the cell membrane, yet mammalian central neurons typically express more than a dozen different types of voltage-dependent ion channels. This rich repertoire of channels allows neurons to encode information by generating action potentials with a wide range of shapes, frequencies and patterns. Recent work offers an increasingly detailed understanding of how the expression of particular channel types underlies the remarkably diverse firing behaviour of various types of neurons.read more
Citations
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Journal ArticleDOI
Dendritic Excitability and Synaptic Plasticity
TL;DR: It is argued that the location of synapses in the dendritic tree, and the type of dendrite excitability associated with each synapse, play decisive roles in determining the plastic properties of that synapse.
Journal ArticleDOI
All-optical electrophysiology in mammalian neurons using engineered microbial rhodopsins
Daniel Hochbaum,Yongxin Zhao,Samouil L. Farhi,Nathan C. Klapoetke,Christopher A. Werley,Vikrant Kapoor,Peng Zou,Joel M. Kralj,Dougal Maclaurin,Niklas Smedemark-Margulies,Jessica L. Saulnier,Gabriella L. Boulting,Christoph Straub,Yong Ku Cho,Michael Melkonian,Gane Ka-Shu Wong,D. Jed Harrison,Venkatesh N. Murthy,Bernardo L. Sabatini,Edward S. Boyden,Robert E. Campbell,Adam E. Cohen +21 more
TL;DR: In this article, a coexpression vector, Optopatch, enabled cross-talk-free genetically targeted all-optical electrophysiology without the use of conventional electrodes.
Journal ArticleDOI
Genetically encoded indicators of neuronal activity
Michael Z. Lin,Mark J. Schnitzer +1 more
TL;DR: This review describes and assess different classes of fluorescent protein indicators of neural activity and focuses on how indicator characteristics relate to their use in living animals and on likely areas of future progress.
Journal ArticleDOI
Unravelling cerebellar pathways with high temporal precision targeting motor and extensive sensory and parietal networks
Fahad Sultan,Mark Augath,Salah Hamodeh,Yusuke Murayama,Axel Oeltermann,Alexander Rauch,Peter Thier +6 more
TL;DR: By electrically stimulating the cerebellum output and imaging responses with functional magnetic resonance imaging, evoked blood oxygen level-dependant activity is observed not only in the classical cerebellar projection target, the primary motor cortex, but also in a number of additional areas in insular, parietal and occipital cortex, including sensory cortical representations.
All-optical electrophysiology in mammalian neurons using engineered microbial rhodopsins
Daniel Hochbaum,Yongxin Zhao,Samouil L. Farhi,Christopher A. Werley,Vikrant Kapoor,Peng Zou,Joel M. Kralj,Dougal Maclaurin,Niklas Smedemark-Margulies,Jessica L. Saulnier,Gabriella L. Boulting,Christoph Straub,Michael Melkonian,Gane Ka-Shu Wong,D. Jed Harrison,Venkatesh N. Murthy,Bernardo L. Sabatini,Robert E. Campbell,Adam E. Cohen,Nathan C. Klapoetke,Yong Ku Cho,Edward S. Boyden +21 more
TL;DR: The Optopatch platform enables high-throughput, spatially resolved electrophysiology without the use of conventional electrodes and revealed homeostatic tuning of intrinsic excitability in human stem cell–derived neurons.
References
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Journal ArticleDOI
A quantitative description of membrane current and its application to conduction and excitation in nerve
A. L. Hodgkin,A. F. Huxley +1 more
TL;DR: This article concludes a series of papers concerned with the flow of electric current through the surface membrane of a giant nerve fibre by putting them into mathematical form and showing that they will account for conduction and excitation in quantitative terms.
Book
Ion Channels of Excitable Membranes
TL;DR: The superfamily of voltage-gated channels was studied in this paper, where a classical biophysics of the squid giant axon was discussed. But the superfamily was not considered in this paper.
Book ChapterDOI
Ion Channels in Excitable Membranes
TL;DR: The action potential is triggered when the membrane potential, which was at the resting level, depolarizes and reaches the threshold of excitation, which triggers the action potential.
Journal ArticleDOI
The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function.
TL;DR: It is proposed that the autorhythmic electrical properties of central neurons and their connectivity form the basis for an intrinsic functional coordinate system that provides internal context to sensory input.
Journal ArticleDOI
Comparative electrophysiology of pyramidal and sparsely spiny stellate neurons of the neocortex.
TL;DR: Slices of sensorimotor and anterior cingulate cortex from guinea pigs were maintained in vitro and bathed in a normal physiological medium, observing three distinct neuronal classes of electrophysiological behavior; these were regular spiking, bursting, and fast spiking.
Related Papers (5)
A quantitative description of membrane current and its application to conduction and excitation in nerve
A. L. Hodgkin,A. F. Huxley +1 more