The Complexity of Human Ribosome Biogenesis Revealed by Systematic Nucleolar Screening of Pre-rRNA Processing Factors
Lionel Tafforeau,Christiane Zorbas,Jean-Louis Langhendries,Sahra-Taylor Mullineux,Vassiliki Stamatopoulou,Romain Mullier,Ludivine Wacheul,Denis L. J. Lafontaine +7 more
TLDR
It is concluded that human cells adopt unique strategies and recruit distinct trans-acting factors to carry out essential processing steps, posing fundamental implications for understanding ribosomopathies at the molecular level and developing effective therapeutic agents.About:
This article is published in Molecular Cell.The article was published on 2013-08-22 and is currently open access. It has received 390 citations till now. The article focuses on the topics: RRNA processing & Ribosome biogenesis.read more
Citations
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A census of human RNA-binding proteins.
TL;DR: This work presents a census of 1,542 manually curated RBPs that are analysed for their interactions with different classes of RNA, their evolutionary conservation, their abundance and their tissue-specific expression, a critical step towards the comprehensive characterization of proteins involved in human RNA metabolism.
Journal ArticleDOI
A large-scale binding and functional map of human RNA-binding proteins
Eric L. Van Nostrand,Peter Freese,Gabriel A. Pratt,Xiaofeng Wang,Xintao Wei,Rui Xiao,Rui Xiao,Steven M. Blue,Jia-Yu Chen,Neal A.L. Cody,Daniel Dominguez,Sara Olson,Balaji Sundararaman,Lijun Zhan,Cassandra Bazile,Louis Philip Benoit Bouvrette,Julie Bergalet,Michael O. Duff,Keri E. Garcia,Chelsea Gelboin-Burkhart,Myles Hochman,Nicole J. Lambert,Hairi Li,Michael P. McGurk,Thai B. Nguyen,Tsultrim Palden,Ines Rabano,Shashank Sathe,Rebecca Stanton,Amanda Su,Ruth Wang,Brian A. Yee,Bing Zhou,Ashley L. Louie,Stefan Aigner,Xiang-Dong Fu,Eric Lécuyer,Eric Lécuyer,Christopher B. Burge,Brenton R. Graveley,Gene W. Yeo +40 more
TL;DR: The spectrum of RBP binding throughout the transcriptome and the connections between these interactions and various aspects of RNA biology, including RNA stability, splicing regulation and RNA localization are described.
Journal ArticleDOI
An overview of pre‐ribosomal RNA processing in eukaryotes
Anthony K. Henras,Célia Plisson-Chastang,Marie-Françoise O'Donohue,Anirban Chakraborty,Pierre-Emmanuel Gleizes +4 more
TL;DR: A consensus scheme of pre‐ribosomal RNA maturation is emerging from studies in various kinds of eukaryotic organisms, including small nucleolar ribonucleoparticles, but major differences between mammalian and yeast pre-ribosome RNA processing have recently come to light.
Journal ArticleDOI
Ribosome biogenesis in cancer: new players and therapeutic avenues
TL;DR: The most recent findings that provide new insights into the molecular basis of ribosome biogenesis in cancer are highlighted and the perspective on how these observations present opportunities for the design of new targeted cancer treatments is offered.
Journal ArticleDOI
Tuning the ribosome: The influence of rRNA modification on eukaryotic ribosome biogenesis and function
Katherine E. Sloan,Ahmed S. Warda,Sunny Sharma,Karl-Dieter Entian,Denis L. J. Lafontaine,Markus T. Bohnsack +5 more
TL;DR: Changes in the rRNA modification pattern have been observed in response to environmental changes, during development, and in disease, which suggests that rRNA modifications may contribute to the translational control of gene expression.
References
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