The CXCL8-CXCR1/2 pathways in cancer
Qian Liu,Anping Li,Yijun Tian,Jennifer D. Wu,Yu Liu,Tengfei Li,Yuan Chen,Xinwei Han,Kongming Wu +8 more
TLDR
Neovascularisation, which provides a basis for fostering tumour growth and metastasis, is now recognised as a critical function of CXCL8 in the tumour microenvironment and it is proposed that CxCL8 may be a potential therapeutic target for cancer treatment.About:
This article is published in Cytokine & Growth Factor Reviews.The article was published on 2016-10-01 and is currently open access. It has received 413 citations till now. The article focuses on the topics: Chemokine receptor & Metastasis.read more
Citations
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Clinical activity and molecular correlates of response to atezolizumab alone or in combination with bevacizumab versus sunitinib in renal cell carcinoma
David F. McDermott,Mahrukh Huseni,Michael B. Atkins,Robert J. Motzer,Brian I. Rini,Bernard Escudier,Lawrence Fong,Richard W. Joseph,Sumanta K. Pal,James A. Reeves,Mario Sznol,John D. Hainsworth,W. Kimryn Rathmell,Walter M. Stadler,Thomas E. Hutson,Martin Gore,Alain Ravaud,Sergio Bracarda,Cristina Suarez,Riccardo Danielli,Viktor Gruenwald,Toni K. Choueiri,Dorothee Nickles,Suchit Jhunjhunwala,Elisabeth Piault-Louis,Alpa Thobhani,Jiaheng Qiu,Daniel S. Chen,Priti S. Hegde,Christina Schiff,Gregg Fine,Thomas Powles +31 more
TL;DR: Molecular profiles suggest that prediction of outcomes with anti-VEGF and immunotherapy may be possible and offer mechanistic insights into how blocking VEGF may overcome resistance to immune checkpoint blockade.
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Interleukin-8 in cancer pathogenesis, treatment and follow-up.
Carlos Alfaro,Miguel F. Sanmamed,Maria E. Rodriguez-Ruiz,Alvaro Teijeira,Carmen Oñate,Alvaro Gonzalez,Mariano Ponz,Kurt A. Schalper,Jose Luis Perez-Gracia,Ignacio Melero +9 more
TL;DR: Given the fact that in cancer patients IL-8 is mainly produced by tumor cells themselves, its serum concentration has been shown to correlate with tumor burden, it is shown to be useful as a pharmacodynamic biomarker to early detect response to immunotherapy.
Journal ArticleDOI
Chemokines Modulate Immune Surveillance in Tumorigenesis, Metastasis, and Response to Immunotherapy.
TL;DR: Both tumor-promoting function of chemokines, such as regulation of tumor metastasis, and beneficial chemokine roles, including stimulation of anti-tumor immunity and response to immunotherapy are reviewed.
Journal ArticleDOI
EGFR-TKIs resistance via EGFR-independent signaling pathways.
TL;DR: Clinical trials aiming to overcome and prevent TKIs resistance in various cancers are ongoing or completed and EGFR-TKIs in accompany with the targeted agents for resistance-related factors afford a promising first-line strategy to further clinical application.
Journal ArticleDOI
Potential roles and targeted therapy of the CXCLs/CXCR2 axis in cancer and inflammatory diseases.
TL;DR: The features and functions of the CXCLs/CXCR2 axis are focused on and its role in cancer and inflammatory diseases is highlighted and its potential use in targeted therapies is discussed.
References
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Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
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SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information
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TL;DR: The latest version of the SWISS-MODEL expert system for protein structure modelling is described, which makes extensive use of model quality estimation for selection of the most suitable templates and provides estimates of the expected accuracy of the resulting models.
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Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN
Zvi G. Fridlender,Jing Sun,Samuel Kim,Veena Kapoor,Guanjun Cheng,Leona E. Ling,G. Scott Worthen,Steven M. Albelda +7 more
TL;DR: It is suggested that TGF-beta within the tumor microenvironment induces a population of TAN with a protumor phenotype, and depletion of these neutrophils significantly blunts antitumor effects of treatment and reduces CD8(+) T cell activation.
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The Interleukin-8 Pathway in Cancer
David Waugh,Catherine Wilson +1 more
TL;DR: Limiting the effects of IL-8 signaling may be a significant therapeutic intervention in targeting the tumor microenvironment because of its role in regulating the transcriptional activity of the androgen receptor.
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Subsets of Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice
TL;DR: A phenotypical and functional analysis of several surface molecules previously suggested to be involved in MDSC-mediated suppression of T cells indicate that suppressive features of M DSC is caused not by expansion of a specific subset but more likely represent a functional state of these cells.
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