The Double Life of Group B Streptococcus: Asymptomatic Colonizer and Potent Pathogen.
Blair Armistead,Elizabeth Oler,Kristina M. Adams Waldorf,Lakshmi Rajagopal,Lakshmi Rajagopal +4 more
TLDR
This review summarizes the GBS and host factors involved in GBS's state as both an asymptomatic colonizer and an invasive pathogen and identifies novel strategies to mitigate GBS virulence.About:
This article is published in Journal of Molecular Biology.The article was published on 2019-07-26 and is currently open access. It has received 72 citations till now.read more
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Temporal development of the infant gut microbiome
TL;DR: Factors that influence the temporal development of the infant microbiome are described, including the mode of delivery and gestational age at birth, maternal and infant perinatal antibiotic infusions, and feeding method—breastfeeding versus formula feeding.
Journal ArticleDOI
Infections at the maternal-fetal interface: an overview of pathogenesis and defence.
Christina Megli,Carolyn B. Coyne +1 more
TL;DR: In this article, Megli et al. discuss how TORCH pathogens access the intra-amniotic space and overcome the placental defences that protect against microbial vertical transmission, and provide an overview of how various viral, bacterial and parasitic pathogens traverse the maternal-fetal interface and cause disease.
Journal ArticleDOI
Host microbiota can facilitate pathogen infection.
TL;DR: In this paper, the authors consider the ways in which a host microbiota contributes to infectious disease throughout the host's life and potentially across evolutionary time and discuss the implications of these negative outcomes for microbiota manipulation and engineering in disease management.
Journal ArticleDOI
Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies
TL;DR: In this paper , the authors evaluate recent studies that characterized microbial populations in human fetuses from the perspectives of reproductive biology, microbial ecology, bioinformatics, immunology, clinical microbiology and gnotobiology, and assess possible mechanisms by which the fetus might interact with microorganisms.
Journal ArticleDOI
Determinants of Group B streptococcal virulence potential amongst vaginal clinical isolates from pregnant women.
Lindsey R. Burcham,Brady L. Spencer,Lauryn R. Keeler,Donna L. Runft,Kathryn A. Patras,Melody N. Neely,Kelly S. Doran,Kelly S. Doran +7 more
TL;DR: Functional assessment of the colonizing isolates revealed that almost all strains exhibited some level of β-hemolytic activity and that ST-17 strains, which express Srr2, exhibited increased bacterial adherence to vaginal epithelium, which provides important information on vaginal GBS carriage isolate virulence potential and highlight the value of continued surveillance.
References
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Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: Implications for the microbial “pan-genome”
Hervé Tettelin,Vega Masignani,Michael J. Cieslewicz,Claudio Donati,Duccio Medini,Naomi L. Ward,Samuel V. Angiuoli,Jonathan Crabtree,Amanda L. Jones,A. Scott Durkin,Robert T. DeBoy,Tanja M. Davidsen,Marirosa Mora,Maria Scarselli,Immaculada Margarit Y Ros,Jeremy Peterson,Christopher R. Hauser,Jaideep P. Sundaram,William C. Nelson,Ramana Madupu,Lauren M. Brinkac,Robert J. Dodson,M. J. Rosovitz,Steven A. Sullivan,Sean C. Daugherty,Daniel H. Haft,Jeremy D. Selengut,Michelle L. Gwinn,Liwei Zhou,Nikhat Zafar,Hoda Khouri,Diana Radune,George Dimitrov,Kisha Watkins,Kevin J. B. O'Connor,Shannon Smith,Teresa Utterback,Owen White,Craig E. Rubens,Guido Grandi,Lawrence C. Madoff,Dennis L. Kasper,John L. Telford,Michael R. Wessels,Rino Rappuoli,Claire M. Fraser +45 more
TL;DR: The genomic sequence of six strains representing the five major disease-causing serotypes of Streptococcus agalactiae, the main cause of neonatal infection in humans, was generated and Mathematical extrapolation of the data suggests that the gene reservoir available for inclusion in the S. agalactic pan-genome is vast and that unique genes will continue to be identified even after sequencing hundreds of genomes.
Journal ArticleDOI
Aspects of the structure, function, and applications of superoxide dismutase
TL;DR: After consideration of the question of superoxide toxicity and superoxide pathology, several areas in which SOD has been investigated or used as a tool in a biochemical, pharmacological, or clinical context are discussed.
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Hyaluronan as an Immune Regulator in Human Diseases
TL;DR: This review focuses on the role of hyaluronan as an immune regulator in human diseases through regulating inflammatory cell recruitment, release of inflammatory cytokines, and cell migration.
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Induction and evasion of host defenses by type 1-piliated uropathogenic Escherichia coli.
Matthew A. Mulvey,Yolanda S. López-Boado,Carole L. Wilson,Robyn Roth,William C. Parks,John E. Heuser,Scott J. Hultgren +6 more
TL;DR: Bacterial attachment resulted in exfoliation of host bladder epithelial cells as part of an innate host defense system through a rapid apoptosis-like mechanism involving caspase activation and host DNA fragmentation.
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Hyaluronan in Tissue Injury and Repair
TL;DR: The interactions between the endogenous matrix component hyaluronan and its signaling receptors initiate inflammatory responses, maintain structural cell integrity, and promote recovery from tissue injury.
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