Journal ArticleDOI
The genetic architecture of schizophrenia, bipolar disorder, obsessive-compulsive disorder and autism spectrum disorder.
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TLDR
Regulation of the hippo signaling pathway was commonly associated with ASD, SCZ, BD and OCD, implicating neural development and neuronal maintenance as key in neuropsychiatric disorders.About:
This article is published in Molecular and Cellular Neuroscience.The article was published on 2018-04-01. It has received 59 citations till now. The article focuses on the topics: Schizophrenia & Autism spectrum disorder.read more
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Geographic variation and bias in polygenic scores of complex diseases and traits in Finland
Sini Kerminen,Alicia R. Martin,Alicia R. Martin,Jukka Koskela,Sanni Ruotsalainen,Aki S. Havulinna,Ida Surakka,Ida Surakka,Aarno Palotie,Markus Perola,Veikko Salomaa,Mark J. Daly,Samuli Ripatti,Matti Pirinen,Matti Pirinen +14 more
TL;DR: In this paper, the authors evaluate geographic differences and related biases, of polygenic scores in Finland with geographically well-defined sample of 2,376 individuals from the National FINRISK study.
Journal ArticleDOI
How obsessive-compulsive and bipolar disorders meet each other? An integrative gene-based enrichment approach.
Sajedeh Hamidian,Abbas Pourshahbaz,Ali Bozorgmehr,Esmaeil Shahsavand Ananloo,Behrooz Dolatshahi,Mina Ohadi +5 more
TL;DR: The role of multiple systems, especially the dopaminergic system in linking OCD and BD is highlighted, and the results can be used to estimate the disease course, prognosis, and treatment choice, particularly in the cases of comorbidity.
Posted ContentDOI
Exploring the genetic overlap between 12 psychiatric disorders
Celia Romero,Josefin Werme,Philip R. Jansen,Joel Gelernter,Murray B. Stein,Daniel Levy,Renato Polimanti,VA Million Veteran Program,Christiaan de Leeuw,Danielle Posthuma,Mats Nagel,Sophie van der Sluis +11 more
TL;DR: Identification of shared biological mechanisms remains challenging due to variation in power and genetic architecture between PDs, with heritability enrichment for "conserved genomic regions" and "nucleotide diversity" was significant for multiple PDs.
Journal ArticleDOI
Autism spectrum disorder in the United Arab Emirates: potential environmental links.
TL;DR: The findings support the notion that there are key links between various environmental factors and ASD prevalence in the UAE, and further studies on its etiology are needed as it poses a serious public health challenge in the region and globally.
Journal ArticleDOI
Aspects of Additional Psychiatric Disorders in Severe Depression/Melancholia: A Comparison between Suicides and Controls and General Pattern
TL;DR: The known increased risk of suicide in MDD with comorbid/additional diagnoses does not seem to apply to persons with MDD-M/P (major depressive disorder-depression/Melancholia), and some diagnoses, such as schizophrenia/schizotypal disorders, were more frequent than expected, which is discussed.
References
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Journal Article
Diagnostic and Statistical Manual of Mental Disorders (DSM-5)
TL;DR: Diagnostic and statistical manual of mental disorders (DSM-5) was translated by psychiatrists and psychologists, mainly from the University psychiatric hospital Vrapce and published by the Naklada Slap publisher.
Journal ArticleDOI
STRING v10: protein–protein interaction networks, integrated over the tree of life
Damian Szklarczyk,Andrea Franceschini,Stefan Wyder,Kristoffer Forslund,Davide Heller,Jaime Huerta-Cepas,Milan Simonovic,Alexander Roth,Alberto Santos,Kalliopi Tsafou,Michael Kuhn,Peer Bork,Lars Juhl Jensen,Christian von Mering +13 more
TL;DR: H hierarchical and self-consistent orthology annotations are introduced for all interacting proteins, grouping the proteins into families at various levels of phylogenetic resolution in the STRING database.
Journal ArticleDOI
Enrichr: a comprehensive gene set enrichment analysis web server 2016 update
Maxim V. Kuleshov,Matthew R. Jones,Andrew D. Rouillard,Nicolas F. Fernandez,Qiaonan Duan,Zichen Wang,Simon Koplev,Sherry L. Jenkins,Kathleen M. Jagodnik,Alexander Lachmann,Michael G. McDermott,Caroline D. Monteiro,Gregory W. Gundersen,Avi Ma'ayan +13 more
TL;DR: A significant update to one of the tools in this domain called Enrichr, a comprehensive resource for curated gene sets and a search engine that accumulates biological knowledge for further biological discoveries is presented.
Journal ArticleDOI
Human DNA methylomes at base resolution show widespread epigenomic differences
Ryan Lister,Mattia Pelizzola,Robert H. Dowen,R. David Hawkins,Gary C. Hon,Julian Tonti-Filippini,Joseph R. Nery,Leonard Lee,Zhen Ye,Que Minh Ngo,Lee Edsall,Jessica Antosiewicz-Bourget,Jessica Antosiewicz-Bourget,Ron Stewart,Ron Stewart,Victor Ruotti,Victor Ruotti,A. Harvey Millar,James A. Thomson,Bing Ren,Bing Ren,Joseph R. Ecker +21 more
TL;DR: The first genome-wide, single-base-resolution maps of methylated cytosines in a mammalian genome, from both human embryonic stem cells and fetal fibroblasts, along with comparative analysis of messenger RNA and small RNA components of the transcriptome, several histone modifications, and sites of DNA-protein interaction for several key regulatory factors were presented in this article.