K
Kevin S. O’Connell
Researcher at Oslo University Hospital
Publications - 87
Citations - 1715
Kevin S. O’Connell is an academic researcher from Oslo University Hospital. The author has contributed to research in topics: Genome-wide association study & Medicine. The author has an hindex of 15, co-authored 60 publications receiving 710 citations. Previous affiliations of Kevin S. O’Connell include University of Cape Town & Stellenbosch University.
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Journal ArticleDOI
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
Niamh Mullins,Andreas J. Forstner,Andreas J. Forstner,Andreas J. Forstner,Kevin S. O’Connell,Kevin S. O’Connell,Brandon J. Coombes,Jonathan R. I. Coleman,Zhen Qiao,Thomas Damm Als,Thomas Damm Als,Tim B. Bigdeli,Tim B. Bigdeli,Sigrid Børte,Sigrid Børte,Sigrid Børte,Julien Bryois,Alexander W. Charney,Ole Kristian Drange,Michael J. Gandal,Saskia P. Hagenaars,Masashi Ikeda,Nolan Kamitaki,Nolan Kamitaki,Minsoo Kim,Kristi Krebs,Georgia Panagiotaropoulou,Brian M. Schilder,Laura G. Sloofman,Stacy Steinberg,Vassily Trubetskoy,Bendik S. Winsvold,Bendik S. Winsvold,Hong-Hee Won,Liliya Abramova,Kristina Adorjan,Esben Agerbo,Esben Agerbo,Mariam M. Al Eissa,Diego Albani,Ney Alliey-Rodriguez,Ney Alliey-Rodriguez,Adebayo Anjorin,Verneri Antilla,Anastasia Antoniou,Swapnil Awasthi,Ji Hyun Baek,Marie Bækvad-Hansen,Marie Bækvad-Hansen,Nicholas Bass,Michael Bauer,Eva C. Beins,Sarah E. Bergen,Armin Birner,Carsten Bøcker Pedersen,Carsten Bøcker Pedersen,Erlend Bøen,Marco P. Boks,Rosa Bosch,Murielle Brum,Ben Michael Brumpton,Nathalie Brunkhorst-Kanaan,Monika Budde,Jonas Bybjerg-Grauholm,Jonas Bybjerg-Grauholm,William Byerley,Murray J. Cairns,Miquel Casas,Pablo Cervantes,Toni-Kim Clarke,Cristiana Cruceanu,Cristiana Cruceanu,Alfredo B. Cuellar-Barboza,Alfredo B. Cuellar-Barboza,Julie M. Cunningham,David Curtis,David Curtis,Piotr M. Czerski,Anders M. Dale,Nina Dalkner,Friederike Sophie David,Franziska Degenhardt,Franziska Degenhardt,Srdjan Djurovic,Srdjan Djurovic,Amanda Dobbyn,Athanassios Douzenis,Torbjørn Elvsåshagen,Torbjørn Elvsåshagen,Valentina Escott-Price,I. Nicol Ferrier,Alessia Fiorentino,Tatiana Foroud,Liz Forty,Josef Frank,Oleksandr Frei,Oleksandr Frei,Nelson B. Freimer,Nelson B. Freimer,Louise Frisén,Katrin Gade,Katrin Gade,Julie Garnham,Joel Gelernter,Joel Gelernter,Marianne Giørtz Pedersen,Marianne Giørtz Pedersen,Ian R. Gizer,Scott D. Gordon,Katherine Gordon-Smith,Tiffany A. Greenwood,Jakob Grove,Jose Guzman-Parra,Kyooseob Ha,Magnús Haraldsson,Martin Hautzinger,Urs Heilbronner,Dennis Hellgren,Stefan Herms,Stefan Herms,Stefan Herms,Per Hoffmann,Per Hoffmann,Per Hoffmann,Peter Holmans,Laura M. Huckins,Stéphane Jamain,Stéphane Jamain,Jessica S. Johnson,Janos Kalman,Yoichiro Kamatani,James L. Kennedy,Sarah Kittel-Schneider,James A. Knowles,Manolis Kogevinas,Maria Koromina,Thorsten M. Kranz,Henry R. Kranzler,Michiaki Kubo,Ralph W. Kupka,Steven A. Kushner,Catharina Lavebratt,Catharina Lavebratt,Jacob Lawrence,Markus Leber,Heon Jeong Lee,Phil Lee,Shawn Levy,Catrin Lewis,Calwing Liao,Calwing Liao,Susanne Lucae,Martin Lundberg,Martin Lundberg,Donald J. MacIntyre,Sigurdur H. Magnusson,Wolfgang Maier,Adam X. Maihofer,Dolores Malaspina,Eirini Maratou,Lina Martinsson,Manuel Mattheisen,Steven A. McCarroll,Steven A. McCarroll,Nathaniel W. McGregor,Peter McGuffin,James McKay,Helena Medeiros,Sarah E. Medland,Vincent Millischer,Vincent Millischer,Grant W. Montgomery,Jennifer L. Moran,Jennifer L. Moran,Derek W. Morris,Thomas W. Mühleisen,Thomas W. Mühleisen,Niamh L. O'Brien,Claire O'Donovan,Loes M. Olde Loohuis,Loes M. Olde Loohuis,Lilijana Oruc,Sergi Papiol,Antonio F. Pardiñas,Amy Perry,Andrea Pfennig,Evgenia Porichi,James B. Potash,Digby Quested,Digby Quested,Towfique Raj,Mark Hyman Rapaport,J. Raymond DePaulo,Eline J. Regeer,John P. Rice,Fabio Rivas,Margarita Rivera,Julian Roth,Panos Roussos,Douglas M. Ruderfer,Cristina Sánchez-Mora,Eva C. Schulte,Fanny Senner,Sally I. Sharp,Paul D. Shilling,Engilbert Sigurdsson,Lea Sirignano,Claire Slaney,Olav B. Smeland,Olav B. Smeland,Daniel J. Smith,Janet L. Sobell,Christine Søholm Hansen,Christine Søholm Hansen,María Soler Artigas,Anne T. Spijker,Dan J. Stein,John Strauss,Beata Świątkowska,Chikashi Terao,Thorgeir E. Thorgeirsson,Claudio Toma,Claudio Toma,Claudio Toma,Paul A. Tooney,Evangelia-Eirini Tsermpini,Marquis P. Vawter,Helmut Vedder,James T.R. Walters,Stephanie H. Witt,Simon Xi,Wei Xu,Jessica Yang,Allan H. Young,Allan H. Young,Hannah Young,Peter P. Zandi,Hang Zhou,Hang Zhou,Lea Zillich,Rolf Adolfsson,Ingrid Agartz,Ingrid Agartz,Martin Alda,Martin Alda,Lars Alfredsson,Gulja Babadjanova,Lena Backlund,Lena Backlund,Bernhard T. Baune,Bernhard T. Baune,Bernhard T. Baune,Frank Bellivier,Susanne Bengesser,Wade H. Berrettini,Douglas Blackwood,Michael Boehnke,Anders D. Børglum,Anders D. Børglum,Gerome Breen,Vaughan J. Carr,Stanley V. Catts,Aiden Corvin,Nicholas John Craddock,Udo Dannlowski,Dimitris Dikeos,Tõnu Esko,Bruno Etain,Panagiotis Ferentinos,Panagiotis Ferentinos,Mark A. Frye,Janice M. Fullerton,Janice M. Fullerton,Micha Gawlik,Elliot S. Gershon,Fernando S. Goes,Melissa J. Green,Melissa J. Green,Maria Grigoroiu-Serbanescu,Joanna Hauser,Frans Henskens,Jan Hillert,Kyung Sue Hong,David M. Hougaard,David M. Hougaard,Christina M. Hultman,Kristian Hveem,Nakao Iwata,Assen Jablensky,Ian Jones,Lisa Jones,René S. Kahn,John R. Kelsoe,George Kirov,Mikael Landén,Mikael Landén,Marion Leboyer,Marion Leboyer,Cathryn M. Lewis,Qingqin S. Li,Jolanta Lissowska,Christine Lochner,Carmel M. Loughland,Nicholas G. Martin,Nicholas G. Martin,Carol A. Mathews,Fermín Mayoral,Susan L. McElroy,Andrew M. McIntosh,Francis J. McMahon,Ingrid Melle,Ingrid Melle,Patricia T. Michie,Lili Milani,Philip B. Mitchell,Gunnar Morken,Ole Mors,Ole Mors,Preben Bo Mortensen,Bryan J. Mowry,Bertram Müller-Myhsok,Bertram Müller-Myhsok,Richard M. Myers,Benjamin M. Neale,Benjamin M. Neale,Caroline M. Nievergelt,Caroline M. Nievergelt,Merete Nordentoft,Merete Nordentoft,Markus M. Nöthen,Michael Conlon O'Donovan,Ketil J. Oedegaard,Tomas Olsson,Michael John Owen,Sara A. Paciga,C Pantelis,Carlos N. Pato,Michele T. Pato,George P. Patrinos,George P. Patrinos,Roy H. Perlis,Danielle Posthuma,Josep Antoni Ramos-Quiroga,Andreas Reif,Eva Z. Reininghaus,Marta Ribasés,Marcella Rietschel,Stephan Ripke,Stephan Ripke,Stephan Ripke,Guy A. Rouleau,Guy A. Rouleau,Takeo Saito,Ulrich Schall,Martin Schalling,Martin Schalling,Peter R. Schofield,Peter R. Schofield,Thomas G. Schulze,Laura J. Scott,Rodney J. Scott,Alessandro Serretti,Cynthia Shannon Weickert,Cynthia Shannon Weickert,Cynthia Shannon Weickert,Jordan W. Smoller,Jordan W. Smoller,Hreinn Stefansson,Kari Stefansson,Kari Stefansson,Eystein Stordal,Fabian Streit,Patrick F. Sullivan,Patrick F. Sullivan,Gustavo Turecki,Arne E. Vaaler,Eduard Vieta,John B. Vincent,Irwin D. Waldman,Thomas W. Weickert,Thomas W. Weickert,Thomas W. Weickert,Thomas Werge,Naomi R. Wray,John-Anker Zwart,John-Anker Zwart,John-Anker Zwart,Joanna M. Biernacka,John I. Nurnberger,Sven Cichon,Howard J. Edenberg,Howard J. Edenberg,Eli A. Stahl,Eli A. Stahl,Andrew McQuillin,Arianna Di Florio,Arianna Di Florio,Roel A. Ophoff,Ole A. Andreassen,Ole A. Andreassen +399 more
TL;DR: The authors performed a genome-wide association study of 41,917 bipolar disorder cases and 371,549 controls of European ancestry, which identified 64 associated genomic loci, including genes encoding targets of antipsychotics, calcium channel blockers, antiepileptics and anesthetics.
Journal ArticleDOI
Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence
Olav B. Smeland,Shahram Bahrami,Oleksandr Frei,Alexey A. Shadrin,Kevin S. O’Connell,Jeanne E. Savage,Kyoko Watanabe,Florian Krull,Francesco Bettella,Nils Eiel Steen,Torill Ueland,Torill Ueland,Danielle Posthuma,Srdjan Djurovic,Srdjan Djurovic,Anders M. Dale,Ole A. Andreassen +16 more
TL;DR: The study demonstrates that both SCZ and BD share genetic influences with intelligence, albeit in a different manner, providing new insights into their genetic architectures.
Journal ArticleDOI
Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation.
Oleksandr Frei,Dominic Holland,Olav B. Smeland,Olav B. Smeland,Alexey A. Shadrin,Chun Chieh Fan,Steffen Maeland,Kevin S. O’Connell,Yunpeng Wang,Yunpeng Wang,Srdjan Djurovic,Srdjan Djurovic,Wesley K. Thompson,Ole A. Andreassen,Ole A. Andreassen,Anders M. Dale +15 more
TL;DR: A statistical tool, MiXeR, is introduced, which quantifies polygenic overlap irrespective of genetic correlation, using GWAS summary statistics to evaluate the polygenicity, discoverability and heritability of complex phenotypes, to improve the understanding of cross-trait genetic architectures.
Journal ArticleDOI
Discovery of shared genomic loci using the conditional false discovery rate approach
Olav B. Smeland,Oleksandr Frei,Alexey A. Shadrin,Kevin S. O’Connell,Chun Chieh Fan,Shahram Bahrami,Dominic Holland,Srdjan Djurovic,Srdjan Djurovic,Wesley K. Thompson,Anders M. Dale,Ole A. Andreassen +11 more
TL;DR: A methodological comparison between condFDR and other relevant cross-trait analytical tools is provided and it is demonstrated howcondFDR analysis may provide novel insights into the genetic relationship between complex phenotypes.
Journal ArticleDOI
Genome-wide association study identifies 48 common genetic variants associated with handedness
Gabriel Cuellar-Partida,Joyce Y. Tung,Nicholas Eriksson,Eva Albrecht,Fazil Aliev,Fazil Aliev,Ole A. Andreassen,Inês Barroso,Inês Barroso,Jacques S. Beckmann,Marco P. Boks,Dorret I. Boomsma,Dorret I. Boomsma,Heather A. Boyd,Monique M.B. Breteler,Harry Campbell,Daniel I. Chasman,Lynn Cherkas,Gail Davies,Eco J. C. de Geus,Eco J. C. de Geus,Ian J. Deary,Panos Deloukas,Danielle M. Dick,David L. Duffy,Johan G. Eriksson,Tõnu Esko,Tõnu Esko,Bjarke Feenstra,Frank Geller,Christian Gieger,Ina Giegling,Scott D. Gordon,Jiali Han,Thomas Hansen,Annette M. Hartmann,Caroline Hayward,Kauko Heikkilä,Andrew A. Hicks,Joel N. Hirschhorn,Joel N. Hirschhorn,Jouke-Jan Hottenga,Jouke-Jan Hottenga,Jennifer E. Huffman,Liang-Dar Hwang,M. Arfan Ikram,Jaakko Kaprio,John P. Kemp,John P. Kemp,Kay-Tee Khaw,Norman Klopp,Bettina Konte,Zoltán Kutalik,Zoltán Kutalik,Jari Lahti,Jari Lahti,Xin Li,Ruth J. F. Loos,Ruth J. F. Loos,Michelle Luciano,Sigurdur H. Magnusson,Massimo Mangino,Pedro Marques-Vidal,Nicholas G. Martin,Wendy L. McArdle,Mark I. McCarthy,Mark I. McCarthy,Carolina Medina-Gomez,Mads Melbye,Mads Melbye,Mads Melbye,Scott Melville,Andres Metspalu,Lili Milani,Vincent Mooser,Mari Nelis,Dale R. Nyholt,Dale R. Nyholt,Kevin S. O’Connell,Roel A. Ophoff,Roel A. Ophoff,Cameron D. Palmer,Aarno Palotie,Teemu Palviainen,Guillaume Paré,Lavinia Paternoster,Leena Peltonen,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx,Ozren Polasek,Ozren Polasek,Peter P. Pramstaller,Inga Prokopenko,Inga Prokopenko,Katri Räikkönen,Samuli Ripatti,Fernando Rivadeneira,Igor Rudan,Dan Rujescu,Johannes H. Smit,Johannes H. Smit,George Davey Smith,Jordan W. Smoller,Jordan W. Smoller,Nicole Soranzo,Tim D. Spector,Beate St Pourcain,Beate St Pourcain,Beate St Pourcain,John M. Starr,Hreinn Stefansson,Stacy Steinberg,Maris Teder-Laving,Gudmar Thorleifsson,Kari Stefansson,Nicholas J. Timpson,André G. Uitterlinden,Cornelia M. van Duijn,Frank J. A. van Rooij,J.M. Vink,J.M. Vink,Peter Vollenweider,Eero Vuoksimaa,Gérard Waeber,Nicholas J. Wareham,Nicole M. Warrington,Dawn M. Waterworth,Thomas Werge,Thomas Werge,H.-Erich Wichmann,Elisabeth Widen,Gonneke Willemsen,Alan F. Wright,Margaret J. Wright,Mousheng Xu,Jing Hua Zhao,Peter Kraft,David A. Hinds,Cecilia M. Lindgren,Reedik Mägi,Benjamin M. Neale,Benjamin M. Neale,David M. Evans,David M. Evans,Sarah E. Medland,Sarah E. Medland +145 more
TL;DR: It is suggested that handedness is highly polygenic and that the genetic variants that predispose to left-handedness may underlie part of the association with some psychiatric disorders.