Journal ArticleDOI
The genetic architecture of schizophrenia, bipolar disorder, obsessive-compulsive disorder and autism spectrum disorder.
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TLDR
Regulation of the hippo signaling pathway was commonly associated with ASD, SCZ, BD and OCD, implicating neural development and neuronal maintenance as key in neuropsychiatric disorders.About:
This article is published in Molecular and Cellular Neuroscience.The article was published on 2018-04-01. It has received 59 citations till now. The article focuses on the topics: Schizophrenia & Autism spectrum disorder.read more
Citations
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Journal ArticleDOI
Geographic Variation and Bias in the Polygenic Scores of Complex Diseases and Traits in Finland
Sini Kerminen,Alicia R. Martin,Alicia R. Martin,Jukka Koskela,Sanni Ruotsalainen,Aki S. Havulinna,Ida Surakka,Ida Surakka,Aarno Palotie,Markus Perola,Veikko Salomaa,Mark J. Daly,Samuli Ripatti,Matti Pirinen,Matti Pirinen +14 more
TL;DR: This work demonstrates how sensitive the geographic patterns of current PSs are for small biases even within relatively homogeneous populations and provides simple tools to identify such biases.
Journal ArticleDOI
Identification of Hub Genes and Key Pathways Associated With Bipolar Disorder Based on Weighted Gene Co-expression Network Analysis.
TL;DR: Thirty hub genes with a high degree of connectivity in the PPI network are significantly enriched in positive regulation of transcription and might have important clinical implications for BD treatment and diagnosis.
Journal ArticleDOI
Comprehensive comparison of social cognitive performance in autism spectrum disorder and schizophrenia
Amy E. Pinkham,Kerrianne E. Morrison,David L. Penn,Philip D. Harvey,Skylar Kelsven,Kelsey Ludwig,Noah J. Sasson +6 more
TL;DR: Findings largely suggest comparable levels of social cognitive impairment in ASD and SCZ, which may support the use of existing social cognitive interventions across disorders, but future work is needed to determine whether the mechanisms underlying these shared impairments are also similar or if these common behavioral profiles may emerge via different pathways.
Journal ArticleDOI
A Review of Default Mode Network Connectivity and Its Association With Social Cognition in Adolescents With Autism Spectrum Disorder and Early-Onset Psychosis.
Aarti Nair,Morgan Jolliffe,Yong Seuk S. Lograsso,Yong Seuk S. Lograsso,Carrie E. Bearden,Carrie E. Bearden +5 more
TL;DR: A narrative review of the literature available through April 2020 on imaging studies of adolescents with either ASD or early-onset psychosis to better understand the shared and unique neural mechanisms of social difficulties across diagnosis from a developmental framework focuses on functional connectivity studies of the default mode network (DMN), as the most extensively studied brain network relevant to social cognition across both groups.
Journal ArticleDOI
Searching for an anchor in an unpredictable world: A computational model of obsessive compulsive disorder
TL;DR: A computational model of obsessive-compulsive disorder is developed on the basis of the well-developed framework of the Bayesian brain, where a difficulty in relying on past events to predict the consequences of patients' own actions and the unfolding of possible events is proposed.
References
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Journal ArticleDOI
Long-term dendritic spine stability in the adult cortex
TL;DR: It is shown that filopodia-like dendritic protrusions, extending and retracting over hours, are abundant in young animals but virtually absent from the adult, providing a potential structural basis for long-term information storage.
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The Drosophila Mst Ortholog, hippo, Restricts Growth and Cell Proliferation and Promotes Apoptosis
TL;DR: Hpo links Sav and Wts to a key regulator of apoptosis, which results in increased tissue growth and impaired apoptosis characterized by elevated levels of the cell cycle regulator cyclin E and apoptosis inhibitor DIAP1.
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Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap
Michael J. Gandal,Jillian R. Haney,Neelroop N. Parikshak,Virpi Leppa,Gokul Ramaswami,Christopher Hartl,Andrew J. Schork,Vivek Appadurai,Alfonso Buil,Thomas Werge,Thomas Werge,Thomas Werge,Chunyu Liu,Chunyu Liu,Kevin P. White,Steve Horvath,Daniel H. Geschwind +16 more
TL;DR: A comprehensive systems-level view of the neurobiological architecture of major neuropsychiatric illness demonstrates pathways of molecular convergence and specificity as well as a substantial causal genetic component.
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Hippo signaling in organ size control
TL;DR: A historical review of this potent growth-regulatory pathway in Drosophila is provided and outstanding questions that will likely be the focus of future investigation are highlighted.
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Whole-Genome Sequencing in Autism Identifies Hot Spots for De Novo Germline Mutation
Jacob J. Michaelson,Yujian Shi,Madhusudan Gujral,Hancheng Zheng,Dheeraj Malhotra,Xin Jin,Minghan Jian,Guangming Liu,Douglas S. Greer,Abhishek Bhandari,Wenting Wu,Roser Corominas,Aine Peoples,Aine Peoples,Amnon Koren,Athurva Gore,Shuli Kang,Guan Ning Lin,Jasper A. Estabillo,Therese E. Gadomski,Balvindar Singh,Kun Zhang,Natacha Akshoomoff,Christina Corsello,Steven A. McCarroll,Lilia M. Iakoucheva,Yingrui Li,Jun Wang,Jun Wang,Jonathan Sebat +29 more
TL;DR: This article investigated global patterns of germline mutation by whole-genome sequencing of monozygotic twins concordant for ASD and their parents and found that hypermutability is a property of ASD genes and may also include nucleotide substitution hot spots.