Journal ArticleDOI
The Growing Impact of Catalysis in the Pharmaceutical Industry
TLDR
In this article, a number of selected, noteworthy industrial examples are discussed to showcase the catalytic technologies that have been successfully practiced on large scales for active pharmaceutical ingredient (API) synthesis.Abstract:
Catalysis has become increasingly important for the pharmaceutical industry Catalysis is a critical technology that enables economical and environmentally-sound manufacturing processes The development of a viable catalytic process for industrial scales is a complex task that requires the collaboration of multiple disciplines In this article, a number of selected, noteworthy industrial examples are discussed to showcase the catalytic technologies that have been successfully practiced on large scales for active pharmaceutical ingredient (API) synthesis, involving transition metal catalysis, biocatalysis and organocatalysis In addition, several examples of potential and future catalytic transformations are included which can be utilized in pharmaceutical industry in large-scale operational settingsread more
Citations
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Catalytic enantioselective C-H functionalization of alcohols by redox-triggered carbonyl addition: Borrowing hydrogen, returning carbon
TL;DR: A broad, new family of enantioselective C-C coupling reactions that are catalyzed by iridium or ruthenium complexes have been developed, which are summarized in this Minireview.
Journal ArticleDOI
Synthesis of axially chiral biaryl compounds by asymmetric catalytic reactions with transition metals
Pauline Loxq,Pauline Loxq,Eric Manoury,Eric Manoury,Rinaldo Poli,Rinaldo Poli,Rinaldo Poli,Eric Deydier,Eric Deydier,Agnès Labande,Agnès Labande +10 more
TL;DR: In this article, the authors summarize the different strategies imagined by chemists to control axial chirality of biaryl structures, focusing on asymmetric catalytic processes with transition metals.
Journal ArticleDOI
Chiral-at-metal complexes and their catalytic applications in organic synthesis.
TL;DR: Key catalytic applications in organic synthesis are presented and how the molecular architectures of the chiral-at-metal complexes lead to stereodifferentiation and, thus to enantiomeric excesses in the products are presented.
Journal ArticleDOI
Continuous manufacturing – the Green Chemistry promise?
Luke Rogers,Klavs F. Jensen +1 more
TL;DR: In this article, a review of Green Chemistry advances resulting when transitioning to continuous manufacturing with focus on Green Chemistry elements inherent in flow chemistry and related separation processes is presented, where the principle of prevention greatly overshadows all other principles.
Journal ArticleDOI
Multimetallic catalysed cross-coupling of aryl bromides with aryl triflates
TL;DR: It is demonstrated that cooperativity between two group 10 metal catalysts—(bipyridine)nickel and (1,3-bis(diphenylphosphino)propane)palladium—enables a general cross-Ullmann reaction (the cross-coupling of two different aryl electrophiles), which will simplify the synthesis of pharmaceuticals, and lead to the discovery of new multimetallic reactions.
References
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Journal ArticleDOI
Palladium-catalyzed cross-coupling reactions of organoboron compounds
Norio Miyaura,Akira Suzuki +1 more
TL;DR: In this paper, a cross-coupling reaction is proposed for coupling 1 -Alkenylboron Derivatives: Synthesis of Conjugated Dienes 6.
Journal ArticleDOI
Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions
TL;DR: This is the first comprehensive review encompassing the large body of work in this field over the past 5 years, and will focus specifically on ligand-directed C–H functionalization reactions catalyzed by palladium.
Journal ArticleDOI
The atom economy--a search for synthetic efficiency
TL;DR: Transition metal-catalyzed methods that are both selective and economical for formation of cyclic structures, of great interest for biological purposes, represent an important starting point for this long-term goal.
Journal ArticleDOI
Aryl-aryl bond formation one century after the discovery of the Ullmann reaction.
Journal ArticleDOI
Aryl-aryl bond formation by transition-metal-catalyzed direct arylation.
TL;DR: A number of improvements have developed the former process into an industrially very useful and attractive method for the construction of aryl -aryl bonds, but the need still exists for more efficient routes whereby the same outcome is accomplished, but with reduced waste and in fewer steps.
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