Journal ArticleDOI
The Growing Impact of Catalysis in the Pharmaceutical Industry
TLDR
In this article, a number of selected, noteworthy industrial examples are discussed to showcase the catalytic technologies that have been successfully practiced on large scales for active pharmaceutical ingredient (API) synthesis.Abstract:
Catalysis has become increasingly important for the pharmaceutical industry Catalysis is a critical technology that enables economical and environmentally-sound manufacturing processes The development of a viable catalytic process for industrial scales is a complex task that requires the collaboration of multiple disciplines In this article, a number of selected, noteworthy industrial examples are discussed to showcase the catalytic technologies that have been successfully practiced on large scales for active pharmaceutical ingredient (API) synthesis, involving transition metal catalysis, biocatalysis and organocatalysis In addition, several examples of potential and future catalytic transformations are included which can be utilized in pharmaceutical industry in large-scale operational settingsread more
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An isocyanide ligand for the rapid quenching and efficient removal of copper residues after Cu/TEMPO-catalyzed aerobic alcohol oxidation and atom transfer radical polymerization
Grzegorz Szczepaniak,Grzegorz Szczepaniak,Jakub Piątkowski,Wojciech Nogaś,Francesca Lorandi,Saigopalakrishna S. Yerneni,Marco Fantin,Anna Ruszczyńska,Alan E. Enciso,Ewa Bulska,Karol Grela,Krzysztof Matyjaszewski +11 more
TL;DR: In this paper, the authors demonstrate that 1,4-bis(3-isocyanopropyl)piperazine can be used as a highly efficient quenching agent (QA) and copper scavenger in Cu/TEMPO alcohol aerobic oxidation (Stahl oxidation) and atom transfer radical polymerization (ATRP).
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Half-Sandwich Ruthenium Catalyst Bearing an Enantiopure Primary Amine Tethered to an N-Heterocyclic Carbene for Ketone Hydrogenation
TL;DR: RuCp*(Kaibene)(MeCN)](PF6) (Cp*) = 1,2,3,4,5-pentamethylcyclopentadienyl), 7, in high yield as a mixture of two diastereomers.
Journal ArticleDOI
Gold‐Catalyzed Diastereoselective Cycloisomerization of Alkylidene‐Cyclopropane‐Bearing 1,6‐Diynes
TL;DR: An unprecedented gold-catalyzed diastereoselective cycloisomerization of 1,6-diynes bearing an alkylidene cyclopropane moiety has been developed and enables rapid access to a variety of 1-trimethylenenorbornanes, which are important building blocks in the preparations of abiotic and sesquiterpene core structures.
Journal ArticleDOI
Catalytic Oxidation Processes for the Upgrading of Terpenes: State-of-the-Art and Future Trends
TL;DR: In this paper, a critical review summarizes some of the most relevant homogeneous or heterogeneous catalysts designed for the oxidation of some abundant terpenic olefins in the last decade (2008-2018).
Journal ArticleDOI
Iridium and Rhodium Complexes Containing Enantiopure Primary Amine-Tethered N-Heterocyclic Carbenes: Synthesis, Characterization, Reactivity, and Catalytic Asymmetric Hydrogenation of Ketones
TL;DR: The imidazolium salt (S,S)-tBuNC3H3NCHPhCHPhNH2]PF6, (S-S)-11·HPF6 is a precursor to the enantiopure Kaibene ligand, tBu-Kaibene, (s,S)11 featuring a tert-butyl group on the N-heterocyclic carbene (NHC) ring-nitrogen atoms as discussed by the authors.
References
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