Journal ArticleDOI
The Growing Impact of Catalysis in the Pharmaceutical Industry
TLDR
In this article, a number of selected, noteworthy industrial examples are discussed to showcase the catalytic technologies that have been successfully practiced on large scales for active pharmaceutical ingredient (API) synthesis.Abstract:
Catalysis has become increasingly important for the pharmaceutical industry Catalysis is a critical technology that enables economical and environmentally-sound manufacturing processes The development of a viable catalytic process for industrial scales is a complex task that requires the collaboration of multiple disciplines In this article, a number of selected, noteworthy industrial examples are discussed to showcase the catalytic technologies that have been successfully practiced on large scales for active pharmaceutical ingredient (API) synthesis, involving transition metal catalysis, biocatalysis and organocatalysis In addition, several examples of potential and future catalytic transformations are included which can be utilized in pharmaceutical industry in large-scale operational settingsread more
Citations
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Chiral Rhodium Complexes Derived From Electron-Rich Phosphine-Phosphites as Asymmetric Hydrogenation Catalysts
TL;DR: In this paper, two chiral cationic rhodium(I) complexes derived from electron-rich dicyclohexylphosphine-phosphite ligands were prepared from enantiopure Sharpless epoxy ethers.
Journal ArticleDOI
Filling the Gaps in the Challenging Asymmetric Hydroboration of 1,1‐Disubstituted Alkenes with Simple Phosphite‐Based Phosphinooxazoline Iridium Catalysts
TL;DR: In this article, a readily accessible phosphinooxazoline-based catalytic system was proposed that can hydroborate a range of 1,1-disubstituted aryl olefins with high enantioselectivity.
Journal ArticleDOI
Oxidative addition to palladium(0) diphosphine complexes: observations of mechanistic complexity with iodobenzene as reactant.
Almira Kurbangalieva,Almira Kurbangalieva,Duncan Carmichael,King Kuok (Mimi) Hii,Anny Jutand,John M. Brown +5 more
TL;DR: Results provide a consistent explanation for the surprising complexity of an apparently simple reaction step and clear dividing line between reactions that give a di- or monophosphine palladium complex after oxidative addition clarifies the participation of the ligand in coupling catalysis.
Journal ArticleDOI
Tetragonal Cu2Se nanoflakes: synthesis using selenated propylamine as Se source and activation of Suzuki and Sonogashira cross coupling reactions.
Ved Vati Singh,Ajai K. Singh +1 more
TL;DR: The metastable tetragonal Cu2Se phase as nanoflakes has been synthesized for the first time by treating CuCl2 taken in a mixture (1:1) of 1-octadecene and oleylamine with H2N-(CH2)3-SePh dissolved in 1- octadecenes to find a better activator.
Journal ArticleDOI
Reaction Monitoring Using SABRE-Hyperpolarized Benchtop (1 T) NMR Spectroscopy
Olga Semenova,Peter M. Richardson,Andrew J. Parrott,Alison Nordon,Meghan E. Halse,Simon B. Duckett +5 more
TL;DR: A series of single-shot 1H NMR measurements are used to monitor the chemical changes that take place in solution through the lifetime of the hyperpolarized response, illustrating how low-cost low-field NMR measurement provide unique insight into a complex catalytic process through a combination of hyperpolarsization and relaxation data.
References
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Journal ArticleDOI
Palladium-catalyzed cross-coupling reactions of organoboron compounds
Norio Miyaura,Akira Suzuki +1 more
TL;DR: In this paper, a cross-coupling reaction is proposed for coupling 1 -Alkenylboron Derivatives: Synthesis of Conjugated Dienes 6.
Journal ArticleDOI
Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions
TL;DR: This is the first comprehensive review encompassing the large body of work in this field over the past 5 years, and will focus specifically on ligand-directed C–H functionalization reactions catalyzed by palladium.
Journal ArticleDOI
The atom economy--a search for synthetic efficiency
TL;DR: Transition metal-catalyzed methods that are both selective and economical for formation of cyclic structures, of great interest for biological purposes, represent an important starting point for this long-term goal.
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Aryl-aryl bond formation one century after the discovery of the Ullmann reaction.
Journal ArticleDOI
Aryl-aryl bond formation by transition-metal-catalyzed direct arylation.
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