Journal ArticleDOI
The Growing Impact of Catalysis in the Pharmaceutical Industry
TLDR
In this article, a number of selected, noteworthy industrial examples are discussed to showcase the catalytic technologies that have been successfully practiced on large scales for active pharmaceutical ingredient (API) synthesis.Abstract:
Catalysis has become increasingly important for the pharmaceutical industry Catalysis is a critical technology that enables economical and environmentally-sound manufacturing processes The development of a viable catalytic process for industrial scales is a complex task that requires the collaboration of multiple disciplines In this article, a number of selected, noteworthy industrial examples are discussed to showcase the catalytic technologies that have been successfully practiced on large scales for active pharmaceutical ingredient (API) synthesis, involving transition metal catalysis, biocatalysis and organocatalysis In addition, several examples of potential and future catalytic transformations are included which can be utilized in pharmaceutical industry in large-scale operational settingsread more
Citations
More filters
Journal ArticleDOI
A General and Practical Palladium‐Catalyzed Direct α‐Arylation of Amides with Aryl Halides
TL;DR: An efficient system for the direct catalytic intermolecular α-arylation of acetamide derivatives with aryl bromides and chlorides is presented, supported by Kwong's indole-based phosphine ligand and provides monoarylated amides in up to 95% yield.
Journal ArticleDOI
Dinuclear Metal‐ProPhenol Catalysts: Development and Synthetic Applications
TL;DR: This review describes in detail the development and synthetic applications of metal-ProPhenol catalysts with a special focus on recent efforts to improve reactivity and selectivity through ligand design and structural modification.
Journal ArticleDOI
Highly Enantioselective Transfer Hydrogenation of Polar Double Bonds by Macrocyclic Iron(II)/(NH)2P2 Catalysts
Raphael Bigler,Antonio Mezzetti +1 more
TL;DR: In this article, a new protocol for the synthesis of 2,2′-((1S,1′S)-ethane-1,2-diylbis(phenylphosphanediyl))dibenzaldehyde ((SP,SP)-5) was described.
Journal ArticleDOI
Reductive Amination of Ketones or Amination of Alcohols over Heterogeneous Cu Catalysts: Matching the Catalyst Support with the N- Alkylating Agent
TL;DR: In this article, the direct reductive amination (DRA) of aldehydes and ketones has been studied, where the carbonyl compound and the amine are mixed with an appropriate reducing agent without prior formation of the intermediate imine.
Journal ArticleDOI
Chitosan: An Upgraded Polysaccharide Waste for Organocatalysis
TL;DR: In this paper, a microreview presents recent achievements in the field of organocatalytic reactions promoted by chitosan as a heterogeneous catalytic material, which can be used either as an insoluble organometrically insoluble material or as a support for organocATalysts.
References
More filters
Journal ArticleDOI
Palladium-catalyzed cross-coupling reactions of organoboron compounds
Norio Miyaura,Akira Suzuki +1 more
TL;DR: In this paper, a cross-coupling reaction is proposed for coupling 1 -Alkenylboron Derivatives: Synthesis of Conjugated Dienes 6.
Journal ArticleDOI
Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions
TL;DR: This is the first comprehensive review encompassing the large body of work in this field over the past 5 years, and will focus specifically on ligand-directed C–H functionalization reactions catalyzed by palladium.
Journal ArticleDOI
The atom economy--a search for synthetic efficiency
TL;DR: Transition metal-catalyzed methods that are both selective and economical for formation of cyclic structures, of great interest for biological purposes, represent an important starting point for this long-term goal.
Journal ArticleDOI
Aryl-aryl bond formation one century after the discovery of the Ullmann reaction.
Journal ArticleDOI
Aryl-aryl bond formation by transition-metal-catalyzed direct arylation.
TL;DR: A number of improvements have developed the former process into an industrially very useful and attractive method for the construction of aryl -aryl bonds, but the need still exists for more efficient routes whereby the same outcome is accomplished, but with reduced waste and in fewer steps.
Related Papers (5)
Large-scale applications of transition metal-catalyzed couplings for the synthesis of pharmaceuticals.
Javier Magano,Joshua R. Dunetz +1 more