Journal ArticleDOI
The Growing Impact of Catalysis in the Pharmaceutical Industry
TLDR
In this article, a number of selected, noteworthy industrial examples are discussed to showcase the catalytic technologies that have been successfully practiced on large scales for active pharmaceutical ingredient (API) synthesis.Abstract:
Catalysis has become increasingly important for the pharmaceutical industry Catalysis is a critical technology that enables economical and environmentally-sound manufacturing processes The development of a viable catalytic process for industrial scales is a complex task that requires the collaboration of multiple disciplines In this article, a number of selected, noteworthy industrial examples are discussed to showcase the catalytic technologies that have been successfully practiced on large scales for active pharmaceutical ingredient (API) synthesis, involving transition metal catalysis, biocatalysis and organocatalysis In addition, several examples of potential and future catalytic transformations are included which can be utilized in pharmaceutical industry in large-scale operational settingsread more
Citations
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Synthesis of Heterocycles via Palladium-Catalyzed Carbonylations
Dialkylbiaryl phosphines in Pd-catalyzed amination: a user's guide
TL;DR: In this paper, the selection of the best choice of reaction conditions and ligand of this class for the most commonly encountered and practically important substrate combinations for Pd-catalyzed amination reactions is discussed.
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Principles and applications of halogen bonding in medicinal chemistry and chemical biology.
TL;DR: The theoretical background defining its strength and directionality, a systematic analysis of its occurrence and interaction geometries in protein-ligand complexes, and recent examples where halogen bonding has been successfully harnessed for lead identification and optimization are provided.
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Supramolecular Luminescent Sensors
TL;DR: Specific focus is placed on the development of new macrocycle hosts since 2010, coupled with considerations of the underlying principles of supramolecular chemistry as well as analytes of interest and common luminophores.
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Palladium-catalyzed migratory insertion of isocyanides: an emerging platform in cross-coupling chemistry.
TL;DR: Palladium-catalyzed reactions involving isocyanide insertion offer a vast potential for the synthesis of nitrogen-containing fine chemicals and the achievements in this emerging field are discussed.
References
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Novel and Efficient Chiral Bisphosphorus Ligands for Rhodium-Catalyzed Asymmetric Hydrogenation
Wenjun Tang,Andrew G. Capacci,Andre White,Shengli Ma,Sonia Rodriguez,Bo Qu,Jolaine Savoie,Nitinchandra D. Patel,Xudong Wei,Nizar Haddad,Nelu Grinberg,Nathan K. Yee,Dhileepkumar Krishnamurthy,Chris H. Senanayake +13 more
TL;DR: A series of structurally novel, operationally convenient, and efficient chiral 2-phosphino-2,3-dihydrobenzo[d][1,3]oxaphosphole ligands was developed and provided excellent enantioselectivities and reactivities in rhodium-catalyzed asymmetric hydrogenation of alpha-(acylamino)acrylates and beta-acryLates.
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Chiral allenylboronic esters: a practical reagent for enantioselective carbon-carbon bond formation
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(Acylaryloxy)acetic acid diuretics. 2. (2-Alkyl-2-aryl-1-oxo-5-indanyloxy)acetic acids.
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Total synthesis of the anti-apoptotic agents iso- and bongkrekic acids.
TL;DR: The first convergent total synthesis of isobongkrekic acid is reported involving three different stereospecific palladium cross-couplings for the formation of the diene units.
Journal ArticleDOI
Catalytic Asymmetric Allylation of Aldehydes and Related Reactions with Bis(((S)‐binaphthoxy)(isopropoxy)titanium) Oxide as a μ‐Oxo‐Type Chiral Lewis Acid
TL;DR: Chiral bis-Ti(IV) oxide (S,S)-3 can be utilized for related reactions such as asymmetric methallylation and propargylation of aldehydes with high enantioselectivity and this asymmetric approach provides a very useful way of obtaining high reactivity and selectivity through the simple introduction of the M-O-M unit into the design of chiral Lewis acid catalysts.
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